Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Luke T. Deary"'
Autor:
Camilla A. Richmond, Manasvi S. Shah, Luke T. Deary, Danny C. Trotier, Horatio Thomas, Dana M. Ambruzs, Lijie Jiang, Bristol B. Whiles, Hannah D. Rickner, Robert K. Montgomery, Alessio Tovaglieri, Diana L. Carlone, David T. Breault
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2403-2411 (2015)
The cellular and molecular mechanisms underlying adaptive changes to physiological stress within the intestinal epithelium remain poorly understood. Here, we show that PTEN, a negative regulator of the PI3K→AKT→mTORC1-signaling pathway, is an imp
Externí odkaz:
https://doaj.org/article/cddef076518c4b6d880192dc6ebfe2f1
Autor:
Bennett K. Wolf, Yanding Zhao, Andrew McCray, William H. Hawk, Luke T. Deary, Nicholas W. Sugiarto, Ian S. LaCroix, Scott A. Gerber, Chao Cheng, Xiaofeng Wang
Publikováno v:
Nature Structural & Molecular Biology. 30:10-21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09cb7b96fd94c3425f03347bc4c22af2
https://doi.org/10.1038/s41594-022-00880-x
https://doi.org/10.1038/s41594-022-00880-x
Autor:
Luke T. Deary, Nicholas Sugiarto, Cameron Pigeon, Sara W. Mayo, Matthew Z. Wilson, Xiaofeng Wang
Publikováno v:
Cancer Research. 83:LB044-LB044
Loss-of-function (LOF) mutations in genes encoding subunits of SWI/SNF chromatin remodeling complexes are found in approximately 25% of human cancers. Colorectal cancers (CRC), the second leading cause of cancer related deaths, are particularly vulne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9421eff904e2b18f6cec1a9a755f9acd
https://doi.org/10.1158/1538-7445.am2023-lb044
https://doi.org/10.1158/1538-7445.am2023-lb044
Autor:
Bennett K, Wolf, Yanding, Zhao, Andrew, McCray, William H, Hawk, Luke T, Deary, Nicholas W, Sugiarto, Ian S, LaCroix, Scott A, Gerber, Chao, Cheng, Xiaofeng, Wang
Publikováno v:
Nature structuralmolecular biology.
The mechanism controlling the dynamic targeting of SWI/SNF has long been postulated to be coordinated by transcription factors (TFs), yet demonstrating a specific TF influence has proven difficult. Here we take a multi-omics approach to interrogate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d708f30ddb49e0c942d5ed7c41c72e2
https://pubmed.ncbi.nlm.nih.gov/36522426
https://pubmed.ncbi.nlm.nih.gov/36522426
Autor:
John W. Hinds, Edmond J. Feris, Owen M. Wilkins, Luke T. Deary, Xiaofeng Wang, Michael D. Cole
Publikováno v:
PLOS ONE. 17:e0272771
MYC is one of the most dysregulated oncogenes and is thought to be fundamental to tumor formation and/or maintenance in many cancer types. This dominant pro-tumor activity makes MYC an attractive target for cancer therapy. However, MYC is a transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00358396cd47ca7146fbb1a67a92eab
https://doi.org/10.1371/journal.pone.0272771
https://doi.org/10.1371/journal.pone.0272771
Autor:
Diana L. Carlone, Rebecca D. Riba‐Wolman, Alessio Tovaglieri, Rudolf Jaenisch, Dana M. Ambruzs, Benjamin E. Mead, Lijie Jiang, David T. Breault, Christopher J. Lengner, Luke T. Deary, Manasvi S. Shah
Publikováno v:
Stem Cells (Dayton, Ohio)
Skeletal progenitor/stem cells (SSCs) play a critical role in postnatal bone growth and maintenance. Telomerase (Tert) activity prevents cellular senescence and is required for maintenance of stem cells in self‐renewing tissues. Here we investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785aab3a86055cfe5fec9ac536b53860
https://pubmed.ncbi.nlm.nih.gov/33438789
https://pubmed.ncbi.nlm.nih.gov/33438789
Autor:
Diana L. Carlone, Luke T. Deary, Camilla A. Richmond, Robert K. Montgomery, David T. Breault, Dana M. Ambruzs, Hannah Rickner, Alessio Tovaglieri, Bristol B. Whiles, Horatio R. Thomas, Manasvi S. Shah, Danny C. Trotier, Lijie Jiang
Publikováno v:
Cell Reports, Vol 13, Iss 11, Pp 2403-2411 (2015)
SummaryThe cellular and molecular mechanisms underlying adaptive changes to physiological stress within the intestinal epithelium remain poorly understood. Here, we show that PTEN, a negative regulator of the PI3K→AKT→mTORC1-signaling pathway, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997b6e6f255e62223899cc6ef4cc6aec
https://doi.org/10.1016/j.celrep.2015.11.035
https://doi.org/10.1016/j.celrep.2015.11.035
Autor:
David T. Breault, Tracy Ediger, Alessio Tovaglieri, Manasvi S. Shah, Diana L. Carlone, Hannah Rickner, Luke T. Deary, Camilla A. Richmond, Fanny Zhou
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 10, Iss 1, Pp 17-26 (2018)
Stem Cell Reports, Vol 10, Iss 1, Pp 17-26 (2018)
Summary The intestinal epithelium serves as an essential barrier to the outside world and is maintained by functionally distinct populations of rapidly cycling intestinal stem cells (CBC ISCs) and slowly cycling, reserve ISCs (r-ISCs). Because disrup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81da26c305040ac8cadd3d3bfda7a035
https://pubmed.ncbi.nlm.nih.gov/29276155
https://pubmed.ncbi.nlm.nih.gov/29276155
Autor:
Cynthia Bamdad, Nelson D. Glennie, Tyler E. Swanson, Andrew K. Stewart, Luke T. Deary, Benoit J. Smagghe, Pengyu Huang
Publikováno v:
Cancer Research. 78:LB-140
Purpose: Investigate the rationale for CAR Ts that target full-length MUC1 (MUC1-FL) rather than the cleaved, growth factor receptor form, MUC1*. Over 75% of solid tumors aberrantly express MUC1. However, attempts to create an effective therapeutic b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3aad91bbf4250cf053e55d1d23cb209
https://doi.org/10.1158/1538-7445.am2018-lb-140
https://doi.org/10.1158/1538-7445.am2018-lb-140
Autor:
P. Huang, Andrew K. Stewart, Cynthia Bamdad, Luke T. Deary, Nelson D. Glennie, Benoit J. Smagghe
Publikováno v:
Cytotherapy. 20:S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a39d6228f217a6bb7fdc624ce337b8cc
https://doi.org/10.1016/j.jcyt.2018.02.007
https://doi.org/10.1016/j.jcyt.2018.02.007