Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Luke T. Coddington"'
Autor:
Reagan L. Pennock, Luke T. Coddington, Xiaohui Yan, Linda Overstreet-Wadiche, Jacques I. Wadiche
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Precise alignment of pre- and postsynaptic elements optimizes the activation of glutamate receptors at excitatory synapses. Nonetheless, glutamate that diffuses out of the synaptic cleft can have actions at distant receptors, a mode of trans
Externí odkaz:
https://doaj.org/article/7ae40411316e4b6b8cb2ac22171ce8fa
Publikováno v:
Nature. 614:294-302
Recent success in training artificial agents and robots derives from a combination of direct learning of behavioural policies and indirect learning through value functions1–3. Policy learning and value learning use distinct algorithms that optimize
Publikováno v:
eLife, Vol 6 (2017)
Golgi cells are the principal inhibitory neurons at the input stage of the cerebellum, providing feedforward and feedback inhibition through mossy fiber and parallel fiber synapses. In vivo studies have shown that Golgi cell activity is regulated by
Externí odkaz:
https://doaj.org/article/5723d950e29949cbb4d7f6843b83a5b4
Publikováno v:
Cell reports. 36(10)
Summary Sensory cues that precede reward acquire predictive (expected value) and incentive (drive reward-seeking action) properties. Mesolimbic dopamine neurons' responses to sensory cues correlate with both expected value and reward-seeking action.
Autor:
Luke T. Coddington
Publikováno v:
Nature Neuroscience. 23:154-156
Rewards direct behavioral adaptation through midbrain dopamine signaling, though the timing of those effects is often ambiguous. Lee and colleagues find that different subpopulations of dopamine neurons obey similar constraints, indirectly regulating
Autor:
Joshua T. Dudman, Luke T. Coddington
Publikováno v:
Patch Clamp Electrophysiology ISBN: 9781071608173
Optogenetic reagents allow for depolarization and hyperpolarization of cells with light. This provides unprecedented spatial and temporal resolution to the control of neuronal activity both in vitro and in vivo. In the intact animal this requires str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9164f8487b2a03db468b83d7165416f9
https://doi.org/10.1007/978-1-0716-0818-0_14
https://doi.org/10.1007/978-1-0716-0818-0_14
Autor:
Luke T, Coddington, Joshua T, Dudman
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2188
Optogenetic reagents allow for depolarization and hyperpolarization of cells with light. This provides unprecedented spatial and temporal resolution to the control of neuronal activity both in vitro and in vivo. In the intact animal this requires str
Publikováno v:
Annual review of neuroscience. 43
Behavior is readily classified into patterns of movements with inferred common goals—actions. Goals may be discrete; movements are continuous. Through the careful study of isolated movements in laboratory settings, or via introspection, it has beco
Autor:
Joshua T. Dudman, Luke T. Coddington
Publikováno v:
Nature neuroscience
Animals adapt their behavior in response to informative sensory cues using multiple brain circuits. The activity of midbrain dopaminergic neurons is thought to convey a critical teaching signal: reward-prediction error. Although reward-prediction err
Autor:
Joshua T. Dudman, Luke T. Coddington
Publikováno v:
Neuron. 104(1)
Animals infer when and where a reward is available from experience with informative sensory stimuli and their own actions. In vertebrates, this is thought to depend upon the release of dopamine from midbrain dopaminergic neurons. Studies of the role