Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Luke Schenck"'
Autor:
Isha Bade, Vikram Karde, Luke Schenck, Marina Solomos, Margaret Figus, Chienhung Chen, Stephanus Axnanda, Jerry Y. Y. Heng
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 883 (2024)
Crystalline active pharmaceutical ingredients with comparable size and surface area can demonstrate surface anisotropy induced during crystallization or downstream unit operations such as milling. To the extent that varying surface properties impacts
Externí odkaz:
https://doaj.org/article/8af3918416d0414f8114e33c4d8fac62
Autor:
Zijian Wang, Marina Solomos, Stephanus Axnanda, Chienhung Chen, Margaret Figus, Luke Schenck, Changquan Calvin Sun
Publikováno v:
Pharmaceutics, Vol 14, Iss 9, p 1901 (2022)
Micronized particles are commonly used to improve the content uniformity (CU), dissolution performance, and bioavailability of active pharmaceutical ingredients (API). Different particle engineering routes have been developed to prepare micron-sized
Externí odkaz:
https://doaj.org/article/bfd99637efed4e50942eb19428a5f1fa
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2017 (2021)
Co-precipitation is an emerging method to generate amorphous solid dispersions (ASDs), notable for its ability to enable the production of ASDs containing pharmaceuticals with thermal instability and limited solubility. As is true for spray drying an
Externí odkaz:
https://doaj.org/article/76eda632e4514bbfb46e57ccd236d7bd
Autor:
Luke Schenck, Christopher Boyce, Derek Frank, Sampada Koranne, Heidi M. Ferguson, Neil Strotman
Publikováno v:
Pharmaceutics, Vol 13, Iss 7, p 1034 (2021)
Amorphous solid dispersions (ASD) have become a well-established strategy to improve exposure for compounds with insufficient aqueous solubility. Of methods to generate ASDs, spray drying is a leading route due to its relative simplicity, availabilit
Externí odkaz:
https://doaj.org/article/7d4e18b8ee1046f1a48b98a3ac340e71
Autor:
Kristen N. Kelsall, Leila M. Foroughi, Derek S. Frank, Luke Schenck, Anthony LaBuda, Adam J. Matzger
Publikováno v:
Molecular Pharmaceutics. 20:1779-1787
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba8e8051b8872681f31564ddab5f6e40
https://doi.org/10.1021/acs.molpharmaceut.2c00970
https://doi.org/10.1021/acs.molpharmaceut.2c00970
Publikováno v:
Pharmaceutical Research. 39:3197-3208
Precipitation of amorphous solid dispersions has gained traction in the pharmaceutical industry given its application to pharmaceuticals with varying physicochemical properties. Although preparing co-precipitated amorphous dispersions (cPAD) in high-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f118e861145f78def82eeea01880475
https://doi.org/10.1007/s11095-022-03416-6
https://doi.org/10.1007/s11095-022-03416-6
Publikováno v:
Molecular Pharmaceutics. 19:3304-3313
Amorphous solid dispersions (ASDs) are a well-documented formulation approach to improve the rate and extent of dissolution for hydrophobic pharmaceuticals. However, weakly basic compounds can complicate standard approaches to ASDs due to pH-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4debb8dd96b659702fbc6b78a2ceac4f
https://doi.org/10.1021/acs.molpharmaceut.2c00456
https://doi.org/10.1021/acs.molpharmaceut.2c00456
Publikováno v:
Journal of Pharmaceutical Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::659d185441fa4ee6814b0a25d3e5b8a2
https://doi.org/10.1016/j.xphs.2023.05.004
https://doi.org/10.1016/j.xphs.2023.05.004
Publikováno v:
Powders; Volume 1; Issue 2; Pages: 88-110
The advantage of nanoparticles to improve bioavailability of poorly soluble drugs is well known. However, the higher-energy state of nanoparticles beneficial for bioavailability presents challenges for both the stability of nanosuspensions and preven
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7c896780a89dada13005cf00c091ac
https://doi.org/10.3390/powders1020008
https://doi.org/10.3390/powders1020008
Autor:
Marina A. Solomos, Ashish Punia, Sugandha Saboo, Christopher John, Christopher W. Boyce, Alexander Chin, Robert V. Taggart, Daniel Smith, Matthew S. Lamm, Luke Schenck
Publikováno v:
Journal of Pharmaceutical Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd3df83a4177eb7f37f32b910d39ac86
https://doi.org/10.1016/j.xphs.2023.02.011
https://doi.org/10.1016/j.xphs.2023.02.011