Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Luke S. Zondagh"'
Autor:
Sheunopa C. Mzezewa, Sylvester I. Omoruyi, Luke S. Zondagh, Sarel F. Malan, Okobi E. Ekpo, Jacques Joubert
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1606-1620 (2021)
Multitarget directed ligands (MTDLs) are emerging as promising treatment options for Alzheimer’s disease (AD). Coumarin derivatives serve as a good starting point for designing MTDLs due to their inherent inhibition of monoamine oxidase (MAO) and c
Externí odkaz:
https://doaj.org/article/d4af1050d3ea43109b836387a213883e
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1596-1605 (2020)
A series of multi-target directed edaravone derivatives bearing N-benzyl pyridinium moieties were designed and synthesised. Edaravone is a potent antioxidant with significant neuroprotective effects and N-benzyl pyridinium has previously exhibited po
Externí odkaz:
https://doaj.org/article/88bdb8b280ef4a81a2e3418a1a1a0b0f
Autor:
Lamya H. Al-Wahaibi, Mario A. Macías, Olivier Blacque, Luke S. Zondagh, Jacques Joubert, Subbiah Thamotharan, María Judith Percino, Ahmed A. B. Mohamed, Ali A. El-Emam
Publikováno v:
Molecules, Vol 27, Iss 21, p 7403 (2022)
Structural analysis and docking studies of three adamantane-linked 1,2,4-triazole N-Mannich bases (1–3) are presented. Compounds 1, 2 and 3 crystallized in the monoclinic P21/c, P21 and P21/n space groups, respectively. Crystal packing of 1 was sta
Externí odkaz:
https://doaj.org/article/475fad3513dd4b20ac2aa9544ee7f20f
Autor:
Doaa A. Osman, Mario A. Macías, Lamya H. Al-Wahaibi, Nora H. Al-Shaalan, Luke S. Zondagh, Jacques Joubert, Santiago Garcia-Granda, Ali A. El-Emam
Publikováno v:
Molecules, Vol 26, Iss 17, p 5335 (2021)
The solid-state structural analysis and docking studies of three adamantane-linked 1,2,4-triazole derivatives are presented. Crystal structure analyses revealed that compound 2 crystallizes in the triclinic P-1 space group, while compounds 1 and 3 cr
Externí odkaz:
https://doaj.org/article/b3a54e29272945c78ed44fae79597776
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 1596-1605 (2020)
A series of multi-target directed edaravone derivatives bearing N-benzyl pyridinium moieties were designed and synthesised. Edaravone is a potent antioxidant with significant neuroprotective effects and N-benzyl pyridinium has previously exhibited po
Autor:
Luke S Zondagh, Santiago García-Granda, Doaa Ahmed Osman, Nora H. Al-Shaalan, Jacques Joubert, Lamya H. Al-Wahaibi, Mario A. Macías, Ali A. El-Emam
Publikováno v:
Molecules, Vol 26, Iss 5335, p 5335 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecules
Volume 26
Issue 17
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecules
Volume 26
Issue 17
This article belongs to the Special Issue Molecular Simulations Applications in Biochemistry and Molecular Biology.
The solid-state structural analysis and docking studies of three adamantane-linked 1,2,4-triazole derivatives are presented. Crys
The solid-state structural analysis and docking studies of three adamantane-linked 1,2,4-triazole derivatives are presented. Crys