Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Luke S. Tain"'
Autor:
Marianna Kapetanou, Tobias Nespital, Luke S. Tain, Andre Pahl, Linda Partridge, Efstathios S. Gonos
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Proteostasis collapses during aging resulting, among other things, in the accumulation of damaged and aggregated proteins. The proteasome is the main cellular proteolytic system and plays a fundamental role in the maintenance of protein homeostasis.
Externí odkaz:
https://doaj.org/article/4c518bf1230e4fd586c29f4f97b177ae
Autor:
Jorge Iván Castillo-Quan, Li Li, Kerri J. Kinghorn, Dobril K. Ivanov, Luke S. Tain, Cathy Slack, Fiona Kerr, Tobias Nespital, Janet Thornton, John Hardy, Ivana Bjedov, Linda Partridge
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 638-650 (2016)
The quest to extend healthspan via pharmacological means is becoming increasingly urgent, both from a health and economic perspective. Here we show that lithium, a drug approved for human use, promotes longevity and healthspan. We demonstrate that li
Externí odkaz:
https://doaj.org/article/ebe05bc7d909406f8b69e27cd265d60a
Autor:
Cédric Debès, Antonios Papadakis, Sebastian Grönke, Özlem Karalay, Luke S. Tain, Athanasia Mizi, Shuhei Nakamura, Oliver Hahn, Carina Weigelt, Natasa Josipovic, Anne Zirkel, Isabell Brusius, Konstantinos Sofiadis, Mantha Lamprousi, Yu-Xuan Lu, Wenming Huang, Reza Esmaillie, Torsten Kubacki, Martin R. Späth, Bernhard Schermer, Thomas Benzing, Roman-Ulrich Müller, Adam Antebi, Linda Partridge, Argyris Papantonis, Andreas Beyer
Publikováno v:
Nature. 616:814-821
Physiological homeostasis becomes compromised during ageing, as a result of impairment of cellular processes, including transcription and RNA splicing1–4. However, the molecular mechanisms leading to the loss of transcriptional fidelity are so far
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ac613ca38195d59f9d28e928d640e98
https://doi.org/10.1038/s41586-023-05922-y
https://doi.org/10.1038/s41586-023-05922-y
Autor:
Luke S Tain, Robert Sehlke, Chirag Jain, Manopriya Chokkalingam, Nagarjuna Nagaraj, Paul Essers, Mark Rassner, Sebastian Grönke, Jenny Froelich, Christoph Dieterich, Matthias Mann, Nazif Alic, Andreas Beyer, Linda Partridge
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 9, Pp 1-19 (2017)
Abstract Lowered activity of the insulin/IGF signalling (IIS) network can ameliorate the effects of ageing in laboratory animals and, possibly, humans. Although transcriptome remodelling in long‐lived IIS mutants has been extensively documented, th
Externí odkaz:
https://doaj.org/article/b2ab6e59cb074d5c909331ce01d05a47
Autor:
Tobias Brandt, Arnaud Mourier, Luke S Tain, Linda Partridge, Nils-Göran Larsson, Werner Kühlbrandt
Publikováno v:
eLife, Vol 6 (2017)
Ageing is a progressive decline of intrinsic physiological functions. We examined the impact of ageing on the ultrastructure and function of mitochondria in mouse and fruit flies (Drosophila melanogaster) by electron cryo-tomography and respirometry.
Externí odkaz:
https://doaj.org/article/486ce999c35c4426af7bc3daf4c0079e
Autor:
Jonathan Paulitz, Luke S Tain, Linda Partridge, Sebastian Grönke, Andreas Beyer, Ralf Leslie Meilenbrock, Jenny Fröhlich, Manopriya Chokkalingam, Matthias Mann, Robert Sehlke, Nagarjuna Nagaraj, Thomas Leech, Ilian Atanassov
Publikováno v:
Elife
eLife
eLife, Vol 10 (2021)
eLife
eLife, Vol 10 (2021)
Reduced activity of the insulin/IGF signalling network increases health during ageing in multiple species. Diverse and tissue-specific mechanisms drive the health improvement. Here, we performed tissue-specific transcriptional and proteomic profiling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6f60c6507e24925d3e48c4d4770e8c
https://doi.org/10.7554/elife.67275
https://doi.org/10.7554/elife.67275
Autor:
Sebastian Grönke, Ilian Atanassov, Thomas Leech, Ralf Leslie Meilenbrock, Jenny Fröhlich, Jonathan Paulitz, Andreas Beyer, Luke S Tain, Matthias Mann, Nagrajuna Nagaraj, Manopriya Chokkalingam, Robert Sehlke, Linda Partridge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fbb4dc3f607d1b4dbd9a87a7eca0e68
https://doi.org/10.7554/elife.67275.sa2
https://doi.org/10.7554/elife.67275.sa2
Autor:
Linda Partridge, Luke S Tain, Tobias Nespital, André Pahl, Marianna Kapetanou, Efstathios S. Gonos
Publikováno v:
Frontiers in Cell and Developmental Biology
Front Cell Dev Biol
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Front Cell Dev Biol
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Proteostasis collapses during aging resulting, among other things, in the accumulation of damaged and aggregated proteins. The proteasome is the main cellular proteolytic system and plays a fundamental role in the maintenance of protein homeostasis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb7ff2a0f14b27c7b4d03842143505c
https://doi.org/10.3389/fcell.2021.625715
https://doi.org/10.3389/fcell.2021.625715
Autor:
Li Li, T. Keith Blackwell, Linda Partridge, Ivana Bjedov, Kerri J. Kinghorn, Sebastian Grönke, Yvonne Hinze, Luke S Tain, Jorge Iván Castillo-Quan
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
Increasing life expectancy is causing the prevalence of age-related diseases to rise, and there is an urgent need for new strategies to improve health at older ages. Reduced activity of insulin/insulin-like growth factor signaling (IIS) and mechanist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::080f245a1608df8d25bc5c1b76ebf2bc
http://europepmc.org/articles/PMC6800352
http://europepmc.org/articles/PMC6800352
Autor:
Sebastian Grönke, Jenny Froehlich, Linda Partridge, Yvonne Hinze, Chirag Jain, Luke S Tain, Tobias Nespital
Publikováno v:
Aging Cell
Reduced insulin/IGF signaling (IIS) extends lifespan in multiple organisms. Different processes in different tissues mediate this lifespan extension, with a set of interplays that remain unclear. We here show that, in Drosophila, reduced IIS activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50369de8bc28f7b1878529944753c86
http://europepmc.org/articles/PMC6974722
http://europepmc.org/articles/PMC6974722