Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Luke S. Manlove"'
Autor:
Pamela C. Rosato, Sathi Wijeyesinghe, J. Michael Stolley, Christine E. Nelson, Rachel L. Davis, Luke S. Manlove, Christopher A. Pennell, Bruce R. Blazar, Clark C. Chen, Melissa A. Geller, Vaiva Vezys, David Masopust
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
The immunosuppressive tumor environment and the lack of functional anti-tumor immunity are major limiting factors in immunotherapy. Here the authors show that human and mouse tumors are infiltrated by virus-specific memory T cells, which can be harne
Externí odkaz:
https://doaj.org/article/5f068cea4ece4349a43cb5cd50da3600
Autor:
Luke S. Manlove, J. Michael Stolley, Christine E. Nelson, Vaiva Vezys, Pamela C. Rosato, Bruce R. Blazar, David Masopust, Christopher A. Pennell, Rachel L. Davis, Melissa A. Geller, Clark C. Chen, Sathi Wijeyesinghe
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
Nature Communications
Nature Communications
The immunosuppressive tumor microenvironment limits the success of current immunotherapies. The host retains memory T cells specific for previous infections throughout the entire body that are capable of executing potent and immediate immunostimulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cdc9cdb869d905e8ac8c978bb51055b
https://doi.org/10.1038/s41467-019-08534-1
https://doi.org/10.1038/s41467-019-08534-1
Autor:
Richard Thomas Williams, Marc K. Jenkins, Luke S. Manlove, Katherine E. Berquam-Vrieze, Kristen E. Pauken, Michael A. Farrar
Publikováno v:
The Journal of Immunology. 195:4028-4037
BCR-ABL+ acute lymphoblastic leukemia patients have transient responses to current therapies. However, the fusion of BCR to ABL generates a potential leukemia-specific Ag that could be a target for immunotherapy. We demonstrate that the immune system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c175d769528aaf8f7a570689fece582b
https://doi.org/10.4049/jimmunol.1501291
https://doi.org/10.4049/jimmunol.1501291
Autor:
Luke S. Manlove, Hideo Yagita, Jason M. Schenkel, Yan Xing, David L. Owen, Kristin A. Hogquist, Michael A. Farrar, Hongbo Chi, Shawn A. Mahmud, Jonathan S. Boomer, Heather Schmitz, Yanyan Wang, Jonathan M. Green
Publikováno v:
Nature immunology
Regulatory T cells (Treg cells) express members of the tumor-necrosis factor (TNF) receptor superfamily (TNFRSF), but the role of those receptors in the thymic development of Treg cells is undefined. We found here that Treg cell progenitors had high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e886a1a75e3d773ab77ba61c6d62e21
https://doi.org/10.1038/ni.2849
https://doi.org/10.1038/ni.2849
Autor:
Pamela Rosato, Sathi Wijeyesinghe, Michael Stolley, Christine Nelson, Rachel L Davis, Luke S Manlove, Christopher A Pennell, Bruce R. Blazar, Clark C Chen, Melissa A Geller, Vaiva Vezys, David Masopust
Publikováno v:
The Journal of Immunology. 202:194.6-194.6
The immunosuppressive tumor microenvironment limits the success of current immunotherapies. The host retains memory T cells specific for previous infections throughout the entire body that are capable of executing potent and immediate immunostimulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7077925435936973509b24d087ae8b72
https://doi.org/10.4049/jimmunol.202.supp.194.6
https://doi.org/10.4049/jimmunol.202.supp.194.6
Autor:
Christine E. Nelson, J. Michael Stolley, Melissa A. Geller, Sathi Wijeyesinghe, Luke S. Manlove, Clark C. Chen, Vaiva Vezys, Rachel L. Davis, David Masopust, Pamela C. Rosato, Christopher A. Pennell, Bruce R. Blazar
Publikováno v:
Cancer Immunology Research. 7:B182-B182
Overcoming the immunosuppressive tumor microenvironment and localizing adoptive cell and checkpoint blockade therapies to solid tumors remain major impediments to successful cancer immunotherapy. Humans experience many viral infections. Once controll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a11257b0056bc9ea19cbc44050707c36
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b182
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-b182
Autor:
Vaiva Vezys, Jason M. Schenkel, Michael A. Farrar, Luke S. Manlove, Kristen E. Pauken, Kezia R. Manlove, Richard Thomas Williams
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 196(11)
Checkpoint blockade-based immunotherapies are effective in cancers with high numbers of nonsynonymous mutations. In contrast, current paradigms suggest that such approaches will be ineffective in cancers with few nonsynonymous mutations. To examine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f37ffd3c65c8e7b149cf5b70a9b3ef1
https://pubmed.ncbi.nlm.nih.gov/27183622
https://pubmed.ncbi.nlm.nih.gov/27183622
Autor:
Jason M. Schenkel, Lalit K. Beura, Luke S. Manlove, David Masopust, Kathryn A. Fraser, Botond Z. Igyártó, Peter J. Southern, Elizabeth M. Steinert
Publikováno v:
Cell. 161(4)
SummaryMemory CD8 T cells protect against intracellular pathogens by scanning host cell surfaces; thus, infection detection rates depend on memory cell number and distribution. Population analyses rely on cell isolation from whole organs, and interpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8b4f64a693d7584638441739594f6df
https://pubmed.ncbi.nlm.nih.gov/25957676
https://pubmed.ncbi.nlm.nih.gov/25957676
Autor:
Michael D. Nyquist, Scott M. Dehm, Robert L. Vessella, Luke S. Manlove, Yingming Li, Tae Hyun Hwang, Daniel F. Voytas, Kevin A. T. Silverstein
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(43)
Androgen receptor (AR) target genes direct development and survival of the prostate epithelial lineage, including prostate cancer (PCa). Thus, endocrine therapies that inhibit the AR ligand-binding domain (LBD) are effective in treating PCa. AR trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41fb9f3e75d8647f57c974df1270e2dd
https://pubmed.ncbi.nlm.nih.gov/25280326
https://pubmed.ncbi.nlm.nih.gov/25280326
Autor:
David A. Largaespada, Jason B. Bell, Natalie K. Wolf, Dominic A. Beckmann, Luke S. Manlove, Eric P. Rahrmann, Branden S. Moriarity, Touba Khurshid, Vincent W. Keng
Publikováno v:
Nucleic Acids Research
Studying complex biological processes such as cancer development, stem cell induction and transdifferentiation requires the modulation of multiple genes or pathways at one time in a single cell. Herein, we describe straightforward methods for rapid a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47887ee9c9c05254f9c740e98ba082f
https://pubmed.ncbi.nlm.nih.gov/23444141
https://pubmed.ncbi.nlm.nih.gov/23444141