Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Luke Muir"'
Autor:
Peter Thomas, Chloe Rees-Spear, Sarah Griffith, Luke Muir, Emma Touizer, Raiees Andrabi, Richard Priest, Jennifer Percival-Alwyn, Darryl Hayward, Amanda Buxton, William Traylen, Benny Chain, Trevor Wattam, Irene Sanjuan Nandin, Laura E. McCoy
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109495- (2024)
Summary: Antigen-specific antibody infusion is known to enhance or suppress germinal center (GC) responses depending on the affinity of the infusion. We hypothesized that infusing monoclonal antibodies (mAbs) of escalating affinity during an immuniza
Externí odkaz:
https://doaj.org/article/0b1bcca32ac54979a20f34a6710b4940
Autor:
Emma Touizer, Aljawharah Alrubayyi, Rosemarie Ford, Noshin Hussain, Pehuén Pereyra Gerber, Hiu-Long Shum, Chloe Rees-Spear, Luke Muir, Ester Gea-Mallorquí, Jakub Kopycinski, Dylan Jankovic, Anna Jeffery-Smith, Christopher L. Pinder, Thomas A. Fox, Ian Williams, Claire Mullender, Irfaan Maan, Laura Waters, Margaret Johnson, Sara Madge, Michael Youle, Tristan J. Barber, Fiona Burns, Sabine Kinloch, Sarah Rowland-Jones, Richard Gilson, Nicholas J. Matheson, Emma Morris, Dimitra Peppa, Laura E. McCoy
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105862- (2023)
Summary: We assessed a cohort of people living with human immunodeficiency virus (PLWH) (n = 110) and HIV negative controls (n = 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all timepoints, PLWH had significantly lower neutralizing antibody (nAb)
Externí odkaz:
https://doaj.org/article/95e40d2350b047459324835a55cd7d61
Autor:
Aljawharah Alrubayyi, Ester Gea-Mallorquí, Emma Touizer, Dan Hameiri-Bowen, Jakub Kopycinski, Bethany Charlton, Natasha Fisher-Pearson, Luke Muir, Annachiara Rosa, Chloe Roustan, Christopher Earl, Peter Cherepanov, Pierre Pellegrino, Laura Waters, Fiona Burns, Sabine Kinloch, Tao Dong, Lucy Dorrell, Sarah Rowland-Jones, Laura E. McCoy, Dimitra Peppa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Understanding the pathology and immunological response to SARS CoV2 infection in specific patient groups is essential for informing the scientific and clinical handling of infections within these patient populations. Here the authors characterise the
Externí odkaz:
https://doaj.org/article/de4813a9861e43bab28f9f0beeed1ff5
Autor:
Anna Jeffery-Smith, Alice R. Burton, Sabela Lens, Chloe Rees-Spear, Jessica Davies, Monika Patel, Robin Gopal, Luke Muir, Felicity Aiano, Katie J. Doores, J. Yimmy Chow, Shamez N. Ladhani, Maria Zambon, Laura E. McCoy, Mala K. Maini
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Memory B cells (MBCs) can provide a recall response able to supplement waning antibodies (Abs) with an affinity-matured response better able to neutralize variant viruses. We studied a cohort of elderly care home residents and younger staff (median a
Externí odkaz:
https://doaj.org/article/4e603982f9904faf8768698a2faaf045
Autor:
Chloe Rees-Spear, Luke Muir, Sarah A. Griffith, Judith Heaney, Yoann Aldon, Jonne L. Snitselaar, Peter Thomas, Carl Graham, Jeffrey Seow, Nayung Lee, Annachiara Rosa, Chloe Roustan, Catherine F. Houlihan, Rogier W. Sanders, Ravindra K. Gupta, Peter Cherepanov, Hans J. Stauss, Eleni Nastouli, Katie J. Doores, Marit J. van Gils, Laura E. McCoy
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108890- (2021)
Summary: Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines show protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the viral entry protein, spike. Because new SARS-CoV-2 variants are
Externí odkaz:
https://doaj.org/article/78e75387f25c4488ad981560e9ef8e93
Autor:
Velislava N. Petrova, Luke Muir, Paul F. McKay, George S. Vassiliou, Kenneth G. C. Smith, Paul A. Lyons, Colin A. Russell, Carl A. Anderson, Paul Kellam, Rachael J. M. Bashford-Rogers
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
A diverse B-cell receptor (BCR) repertoire is required to bind a wide range of antigens. BCRs are generated through genetic recombination and can be diversified through somatic hypermutation (SHM) or class-switch recombination (CSR). Patterns of repe
Externí odkaz:
https://doaj.org/article/b6c963f72e5647b2ac02634b482d23a7
Autor:
Luke Muir, Paul F. McKay, Velislava N. Petrova, Oleksiy V. Klymenko, Sven Kratochvil, Christopher L. Pinder, Paul Kellam, Robin J. Shattock
Publikováno v:
Wellcome Open Research, Vol 2 (2018)
Background: Human memory B cells play a vital role in the long-term protection of the host from pathogenic re-challenge. In recent years the importance of a number of different memory B cell subsets that can be formed in response to vaccination or in
Externí odkaz:
https://doaj.org/article/b5a3c3da8db74ff9b512cf6c41b86ee0
Autor:
Sven Kratochvil, Paul F. McKay, Jakub T. Kopycinski, Cynthia Bishop, Peter John Hayes, Luke Muir, Christopher L. Pinder, Deniz Cizmeci, Deborah King, Yoann Aldon, Bruce D. Wines, P. Mark Hogarth, Amy W. Chung, Stephen J. Kent, Kathrin Held, Christof Geldmacher, Len Dally, Nelson S. Santos, Tom Cole, Jill Gilmour, Sarah Fidler, Robin J. Shattock
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
A key aspect to finding an efficacious human immunodeficiency virus (HIV) vaccine is the optimization of vaccine schedules that can mediate the efficient maturation of protective immune responses. In the present study, we investigated the effect of a
Externí odkaz:
https://doaj.org/article/4c3b30ccf3f844fdb4a1bdab3e84d4fd
Autor:
Emma Touizer, Aljawharah Alrubbayi, Rosemarie Ford, Noshin Hussain, Pehuén Pereyra Gerber, Hiu-Long Shum, Chloe Rees-Spear, Luke Muir, Ester Gea-Mallorquí, Jakub Kopycinski, Dylan Jankovic, Christopher Pinder, Thomas A Fox, Ian Williams, Claire Mullender, Irfaan Maan, Laura Waters, Margaret Johnson, Sara Madge, Michael Youle, Tristan Barber, Fiona Burns, Sabine Kinloch, Sarah Rowland-Jones, Richard Gilson, Nicholas J Matheson, Emma Morris, Dimitra Peppa, Laura E McCoy
People living with HIV (PLWH) on suppressive antiretroviral therapy (ART) can have residual immune dysfunction and often display poorer responses to vaccination. We assessed in a cohort of PLWH (n=110) and HIV negative controls (n=64) the humoral and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5751d0504285828833ed9e416b6e0bc5
https://doi.org/10.1101/2022.11.11.516111
https://doi.org/10.1101/2022.11.11.516111
Autor:
Emma Touizer, Aljawharah Alrubayyi, Rosemarie Ford, Noshin Hussain, Pehuén Pereyra Gerber, Hiu-Long Shum, Chloe Rees-Spear, Luke Muir, Ester Gea-Mallorquí, Jakub Kopycinski, Dylan Jankovic, Anna Jeffery-Smith, Christopher L. Pinder, Thomas A. Fox, Ian Williams, Claire Mullender, Irfaan Maan, Laura Waters, Margaret Johnson, Sara Madge, Michael Youle, Tristan J. Barber, Fiona Burns, Sabine Kinloch, Sarah Rowland-Jones, Richard Gilson, Nicholas J. Matheson, Emma Morris, Dimitra Peppa, Laura E. McCoy
Publikováno v:
iScience.
We assessed a cohort of people living with human immunodeficiency virus (PLWH) (n = 110) and HIV negative controls (n = 64) after 1, 2 or 3 SARS-CoV-2 vaccine doses. At all timepoints, PLWH had significantly lower neutralizing antibody (nAb) titers t