Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Luke M Healy"'
Autor:
Carl Laflamme, Paul M McKeever, Rahul Kumar, Julie Schwartz, Mahshad Kolahdouzan, Carol X Chen, Zhipeng You, Faiza Benaliouad, Opher Gileadi, Heidi M McBride, Thomas M Durcan, Aled M Edwards, Luke M Healy, Janice Robertson, Peter S McPherson
Publikováno v:
eLife, Vol 8 (2019)
Antibodies are a key resource in biomedical research yet there are no community-accepted standards to rigorously characterize their quality. Here we develop a procedure to validate pre-existing antibodies. Human cell lines with high expression of a t
Externí odkaz:
https://doaj.org/article/5dd99f539d7743e5b6734eaf3c37ed67
Autor:
Andrew D Greenhalgh, Juan G Zarruk, Luke M Healy, Sam J Baskar Jesudasan, Priya Jhelum, Christopher K Salmon, Albert Formanek, Matthew V Russo, Jack P Antel, Dorian B McGavern, Barry W McColl, Samuel David
Publikováno v:
PLoS Biology, Vol 16, Iss 10, p e2005264 (2018)
Infiltrating monocyte-derived macrophages (MDMs) and resident microglia dominate central nervous system (CNS) injury sites. Differential roles for these cell populations after injury are beginning to be uncovered. Here, we show evidence that MDMs and
Externí odkaz:
https://doaj.org/article/1c8702fa041d44d89c739f6aa96e8779
Autor:
Vijayaraghava T S Rao, Damla Khan, Qiao-Ling Cui, Shih-Chieh Fuh, Shireen Hossain, Guillermina Almazan, Gerhard Multhaup, Luke M Healy, Timothy E Kennedy, Jack P Antel
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182372 (2017)
Within the microenvironment of multiple sclerosis lesions, oligodendrocytes are subject to metabolic stress reflecting effects of focal ischemia and inflammation. Previous studies have shown that under optimal conditions in vitro, the respiratory act
Externí odkaz:
https://doaj.org/article/3248b6af0fbd42e099bcec40e72e0f4d
Autor:
Marie-France Dorion, Diana Casas, Irina Shlaifer, Moein Yaqubi, Peter Fleming, Nathan Karpilovsky, Carol X.-Q. Chen, Michael Nicouleau, Valerio E. C. Piscopo, Emma J. MacDougall, Aeshah Alluli, Taylor M. Goldsmith, Alexandria Schneider, Samuel Dorion, Nathalia Aprahamian, Adam MacDonald, Rhalena A. Thomas, Roy W. R. Dudley, Jeffrey A. Hall, Edward A. Fon, Jack P. Antel, Jo Anne Stratton, Thomas M. Durcan, Roberta La Piana, Luke M. Healy
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-26 (2024)
Abstract Background Induced pluripotent stem cell-derived microglia (iMGL) represent an excellent tool in studying microglial function in health and disease. Yet, since differentiation and survival of iMGL are highly reliant on colony-stimulating fac
Externí odkaz:
https://doaj.org/article/aa6be16cdc4045c0b1747096bb52aa8a
Autor:
Moein Yaqubi, Adam M. R. Groh, Marie-France Dorion, Elia Afanasiev, Julia Xiao Xuan Luo, Hadi Hashemi, Sarthak Sinha, Nicholas W. Kieran, Manon Blain, Qiao-Ling Cui, Jeff Biernaskie, Myriam Srour, Roy Dudley, Jeffery A. Hall, Joshua A. Sonnen, Nathalie Arbour, Alexandre Prat, Jo Anne Stratton, Jack Antel, Luke M. Healy
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-18 (2023)
Abstract Background Microglia are tissue resident macrophages with a wide range of critically important functions in central nervous system development and homeostasis. Method In this study, we aimed to characterize the transcriptional landscape of e
Externí odkaz:
https://doaj.org/article/af75dc06fd684de888eae1e621a52263
Autor:
Moein Yaqubi, Julia Xiao Xuan Luo, Salma Baig, Qiao‐Ling Cui, Kevin Petrecca, Haritha Desu, Catherine Larochelle, Elia Afanasiev, Jeffery A. Hall, Roy Dudley, Myriam Srour, Lisbet Haglund, Jean Ouellet, Miltiadis Georgiopoulos, Carlo Santaguida, Joshua A. Sonnen, Luke M. Healy, Jo Anne Stratton, Timothy E. Kennedy, Jack P. Antel
Publikováno v:
Glia. 70:1938-1949
Morphological and emerging molecular studies have provided evidence for heterogeneity within the oligodendrocyte population. To address the regional and age-related heterogeneity of human mature oligodendrocytes (MOLs) we applied single-cell RNA sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482347fbbf515972102e80bc2b577c74
https://doi.org/10.1002/glia.24230
https://doi.org/10.1002/glia.24230
Autor:
Nicholas W. Kieran, Rahul Suresh, Marie-France Dorion, Adam MacDonald, Manon Blain, Dingke Wen, Shih-Chieh Fuh, Fari Ryan, Roberto J. Diaz, Jo Anne Stratton, Samuel K. Ludwin, Joshua A. Sonnen, Jack Antel, Luke M. Healy
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Journal of Neuroinflammation
Journal of Neuroinflammation
BackgroundAstrocytes are the most numerous glial cell type with important roles in maintaining homeostasis and responding to diseases in the brain. Astrocyte function is subject to modulation by microRNAs (miRs), which are short nucleotide strands th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f37efb6d1b0db2808727cf25d4e9b84
https://doaj.org/article/ff9143aea5044c8bb659c5975e5fd61a
https://doaj.org/article/ff9143aea5044c8bb659c5975e5fd61a
Autor:
Marie-France Dorion, Moein Yaqubi, Hunter J. Murdoch, Jeffery A. Hall, Roy Dudley, Jack P. Antel, Thomas M. Durcan, Luke M. Healy
Efforts to understand microglia function in health and diseases have been hindered by the lack of culture models that recapitulate in situ cellular properties. In recent years, the use of serum-free media with brain-derived growth factors (CSF1R liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::607ace24eedc71b75cca1219704b1f78
https://doi.org/10.1101/2022.07.14.500101
https://doi.org/10.1101/2022.07.14.500101
Publikováno v:
Communications biology. 5(1)
High dimensional single-cell analysis such as single cell and single nucleus RNA sequencing (sc/snRNAseq) are currently being widely applied to explore microglia diversity. The use of sc/snRNAseq provides a powerful and unbiased approach to deconvolv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb48b09eeaff7a23649d34dec9793c7
https://pubmed.ncbi.nlm.nih.gov/36266565
https://pubmed.ncbi.nlm.nih.gov/36266565
Autor:
Shannon Tansley, Sonali Uttam, Alba Ureña Guzmán, Moein Yaqubi, Alain Pacis, Marc Parisien, Haley Deamond, Calvin Wong, Oded Rabau, Nicole Brown, Lisbet Haglund, Jean Ouellet, Carlo Santaguida, Alfredo Ribeiro-da-Silva, Soroush Tahmasebi, Masha Prager-Khoutorsky, Jiannis Ragoussis, Ji Zhang, Michael W. Salter, Luda Diatchenko, Luke M. Healy, Jeffrey S. Mogil, Arkady Khoutorsky
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Activation of microglia in the spinal cord following peripheral nerve injury is critical for the development of long-lasting pain hypersensitivity. However, it remains unclear whether distinct microglia subpopulations or states contribute to differen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032344204dce564ccd95da86e1e96e6e
https://doi.org/10.1038/s41467-022-28473-8
https://doi.org/10.1038/s41467-022-28473-8