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Abstract 344: PKC-ι is a simultaneous modulator of the sonic hedgehog and the FAK/paxillin pathways in medulloblastoma

Autor: Luke Lajmi, Sloan Breedy, Aaron Todman, Wishrawana S. Ratnayake, Mildred Acevedo-Duncan

Publikováno v: Cancer Research. 83:344-344

Medulloblastoma is the second most common childhood cancer, behind leukemia, and the most common pediatric brain tumor, comprising 20% of all childhood brain cancers. Our data demonstrated the effectiveness of atypical protein kinase C (aPKC) inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7c2aebd2a6ee725616d9d0b255f3468
https://doi.org/10.1158/1538-7445.am2023-344

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Abstract 2555: 14-3-3 and Smad2/3 are key mediators of atypical-PKCs in neuroblastoma progression

Autor: Sloan Breedy, Wishrawana S. Ratnayake, Luke Lajmi, Robert Hill, Mildred Acevedo-Duncan

Publikováno v: Cancer Research. 83:2555-2555

Neuroblastoma (NB) is a cancer that develops in the neuroblasts. It is the most common cancer in children under the age of 1 year, accounting for approximately 6% of all cancers. The prognosis of NB is linked to both age and degree of cell differenti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46c47e9117f88d8c4b557398a3d6b8a0
https://doi.org/10.1158/1538-7445.am2023-2555

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Abstract 158: A combination therapy of atypical protein kinase C inhibitors and phosphatidylinositol-3-kinase inhibitor reduces resistance & invasiveness in renal cell carcinoma (RCC)

Autor: Khandker Mohammad Khalid, Wishrawana S. Ratnayake, Christopher A. Apostolatos, Luke Lajmi, Sloan Breedy, Nuzhat N. Oishee, Mildred Acevedo-Duncan

Publikováno v: Cancer Research. 82:158-158

Renal Cell Carcinoma (RCC) is the most common type of kidney cancer (85%) of which 75% of the cases involve conventional clear cell RCC (ccRCC). Choice of treatments recommended for clear cell carcinoma and non-clear cell carcinoma are partial nephre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::518d7a59f54fddfdde49c30a09278a00
https://doi.org/10.1158/1538-7445.am2022-158

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Abstract 150: Prevalent PKC-ι/ζ signaling is crucial for apoptosis inhibition and invasiveness of glioblastoma through upregulation of Pdk1/Akt1/14-3-3 cascade and Smad2/3

Autor: Wishrawana Sarathi Ratnayake, Khandker M. Khalid, Sloan Breedy, Luke Lajmi, Tracess Smalley, Christopher A. Apostolatos, Robert Hill, James Fackrell, Mildred Acevedo-Duncan

Publikováno v: Cancer Research. 82:150-150

Glioblastoma (GB) is an aggressive form of cancer derived from astrocytes and often found in brain or spinal cord. Poor prognosis of GB has limitations in current therapeutics mainly due to the development of resistance. Our results demonstrated that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::679d60b2e25296c6eb85b2f07a271a37
https://doi.org/10.1158/1538-7445.am2022-150

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Abstract 172: Limiting medulloblastoma progression by hindering the Hedgehog signaling pathway with novel atypical protein kinase C inhibitors

Autor: Luke Lajmi, Sloan Breedy, Wishrawana S. Ratnayake, Mildred Acevedo-Duncan

Publikováno v: Cancer Research. 82:172-172

Medulloblastoma is the most common pediatric brain tumor, constituting 20% of all childhood brain cancers (Clin. Cancer Res. 2008, 14 (4), 971-976., Oncogenesis 2019, 8 (11), 1-11). It is a highly invasive tumor that originates in the cerebellum and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d46b608d5fe5d52f763e6d2bf5875d64
https://doi.org/10.1158/1538-7445.am2022-172

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