Lorcaserin improves glycemic control via a melanocortin neurocircuit

Autor: Luke K. Burke, Emmanuel Ogunnowo-Bada, Teodora Georgescu, Claudia Cristiano, Pablo B. Martinez de Morentin, Lourdes Valencia Torres, Giuseppe D'Agostino, Christine Riches, Nicholas Heeley, Yue Ruan, Marcelo Rubinstein, Malcolm J. Low, Martin G. Myers, Justin J. Rochford, Mark L. Evans, Lora K. Heisler

Publikováno v: Molecular Metabolism, Vol 6, Iss 10, Pp 1092-1102 (2017)

Objective: The increasing prevalence of type 2 diabetes (T2D) and associated morbidity and mortality emphasizes the need for a more complete understanding of the mechanisms mediating glucose homeostasis to accelerate the identification of new medicat

Externí odkaz: https://doaj.org/article/d5d57fc4ef3a41a08e876808e1d9eeec

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

Autor: Luke K Burke, Tamana Darwish, Althea R Cavanaugh, Sam Virtue, Emma Roth, Joanna Morro, Shun-Mei Liu, Jing Xia, Jeffrey W Dalley, Keith Burling, Streamson Chua, Toni Vidal-Puig, Gary J Schwartz, Clémence Blouet

Publikováno v: eLife, Vol 6 (2017)

Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the bra

Externí odkaz: https://doaj.org/article/cfa6ba77c17c4c99b02a679f8fe69bff

Neurochemical Characterization of Brainstem Pro-Opiomelanocortin Cells

Autor: Oliver J. Marston, Luke K. Burke, Lora K. Heisler, Teodora Georgescu, Brian Y.H. Lam, Barbora Doslikova, David J. Lyons, Ana Paula Garcia, Justin J. Rochford, Raffaella Chianese, Giles S.H. Yeo, Alastair S. Garfield

Publikováno v: Endocrinology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Genetic research has revealed pro-opiomelanocortin (POMC) to be a fundamental regulator of energy balance and body weight in mammals. Within the brain, POMC is primarily expressed in the arcuate nucleus of the hypothalamus (ARC), while a smaller popu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df15b62dc24f2fe697868e61086e97fe
https://doi.org/10.1210/endocr/bqaa032

mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

Autor: Streamson C. Chua, Tamana Darwish, Keith Burling, Toni Vidal-Puig, Joanna Morro, Luke K. Burke, Sam Virtue, Clemence Blouet, Gary J. Schwartz, Althea R. Cavanaugh, Jing Xia, Shun Mei Liu, Emma Roth, Jeffrey W. Dalley

Publikováno v: eLife, Vol 6 (2017)
eLife

Energy dissipation through interscapular brown adipose tissue (iBAT) thermogenesis is an important contributor to adaptive energy expenditure. However, it remains unresolved how acute and chronic changes in energy availability are detected by the bra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b428118a3ba97dd3b90d5452a10b0ac
https://elifesciences.org/articles/22848

Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite

Autor: Luke K. Burke, Lawrence Stephen Wilkinson, Alastair S. Garfield, Anthony Roger Isles, Jennifer R. Davies, Lora K. Heisler, Hannah Furby

Publikováno v: Garfield, A S, Davies, J R, Burke, L K, Furby, H V, Wilkinson, L S, Heisler, L K & Isles, A R 2016, ' Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT 2C receptor mediated appetite ', Molecular Brain, vol. 9, 95 . https://doi.org/10.1186/s13041-016-0277-4, https://doi.org/10.1186/s13041-016-0277-4
Molecular Brain

Alternate splicing of serotonin (5-hydroxytryptamine; 5-HT) 2C receptor (5-HT2CR) pre-RNA is negatively regulated by the small nucleolar RNA, Snord115, loss of which is observed in nearly all individuals with Prader-Willi Syndrome (PWS), a multigenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c943a4e7aa752d5bb230a682c6a5c3
https://doi.org/10.1186/s13041-016-0277-4