Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Luke J. Leman"'
Autor:
Moran Frenkel-Pinter, Marcos Bouza, Facundo M. Fernández, Luke J. Leman, Loren Dean Williams, Nicholas V. Hud, Aikomari Guzman-Martinez
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
One of the early processes enabling the origins of life is thought to be the condensation of building blocks into oligomers and polymers. In this article, the authors report the synthesis of thiodepsipeptides and HS-peptides under mild temperatures a
Externí odkaz:
https://doaj.org/article/df6d52a3f47240ee80e477d8bbe3f713
Autor:
Moran Frenkel-Pinter, Jay W. Haynes, Ahmad M. Mohyeldin, Martin C, Alyssa B. Sargon, Anton S. Petrov, Ramanarayanan Krishnamurthy, Nicholas V. Hud, Loren Dean Williams, Luke J. Leman
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Cooperative relationships are widespread among different classes of biopolymers and are predicted to have existed during emergence of life. This study shows that proto-peptides engage in mutually stabilizing interactions with RNA, providing support f
Externí odkaz:
https://doaj.org/article/ce86f8db408449cc807579afb0ac893f
Autor:
Yannan Zhao, Luke J. Leman, Debra J. Search, Ricardo A. Garcia, David A. Gordon, Bruce E. Maryanoff, M. Reza Ghadiri
Publikováno v:
ACS Central Science, Vol 3, Iss 6, Pp 639-646 (2017)
Externí odkaz:
https://doaj.org/article/79d86141bf414ff88872dae140df8331
Autor:
Yannan Zhao, Audrey S. Black, David J. Bonnet, Bruce E. Maryanoff, Linda K. Curtiss, Luke J. Leman, M. Reza Ghadiri
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 10, Pp 2053-2063 (2014)
We have observed that molecular constructs based on multiple apoA-I mimetic peptides attached to a branched scaffold display promising anti-atherosclerosis functions in vitro. Building on these promising results, we now describe chronic in vivo studi
Externí odkaz:
https://doaj.org/article/4f3fefe053a342ae9ef59f6a82541f30
Publikováno v:
Chemical Science. 13:13741-13747
Protein (pyro)phosphorylation is emerging as a post-translational modification (PTM) in signalling pathways involved in many cellular processes. However, access to synthetic pyrophosphopeptides that can serve as tools for understanding protein pyroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5708bfb4b0081b7e2f7258210f6591
https://doi.org/10.1039/d2sc04160j
https://doi.org/10.1039/d2sc04160j
Autor:
Poshen B. Chen, Jiejun Wu, Pejman Soroosh, Bhuvan Molparia, German R. Aleman Muench, Luke J. Leman, Alan Saghatelian, Weixuan Chen, M. Reza Ghadiri, Audrey S. Black, Purba Mukherjee, Ali Torkamani, Nina E. Moore, Antonio Pinto, Adam L. Sobel, Bruce E. Maryanoff, Yannan Zhao
Publikováno v:
Nature biotechnology
The gut microbiome is a malleable microbial community that can remodel in response to various factors, including diet, and contribute to the development of several chronic diseases, including atherosclerosis. We devised an in vitro screening protocol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::725b1b12d5c6263bc961861a641060bf
https://doi.org/10.1038/s41587-020-0549-5
https://doi.org/10.1038/s41587-020-0549-5
Autor:
Jay W. Haynes, Loren Dean Williams, Ahmad M. Mohyeldin, Nicholas V. Hud, Moran Frenkel-Pinter, Luke J. Leman, Alyssa B. Sargon, Ramanarayanan Krishnamurthy, Anton S. Petrov, Martin C
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications
Nature Communications
The close synergy between peptides and nucleic acids in current biology is suggestive of a functional co-evolution between the two polymers. Here we show that cationic proto-peptides (depsipeptides and polyesters), either produced as mixtures from pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eafd2c1181785b5723fe6bc02df9abd9
http://link.springer.com/article/10.1038/s41467-020-16891-5
http://link.springer.com/article/10.1038/s41467-020-16891-5
Autor:
Martin C, Moran Frenkel-Pinter, Kelvin H. Smith, Victor F. Rivera-Santana, Alyssa B. Sargon, Kaitlin C. Jacobson, Aikomari Guzman-Martinez, Loren Dean Williams, Luke J. Leman, Charles L. Liotta, Martha A. Grover, Nicholas V. Hud
Publikováno v:
JACS Au. 2(6)
The high kinetic barrier to amide bond formation has historically placed narrow constraints on its utility in reversible chemistry applications. Slow kinetics has limited the use of amides for the generation of diverse combinatorial libraries and sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e990f95e8bb6c7f852a0d1a975141499
https://pubmed.ncbi.nlm.nih.gov/35783166
https://pubmed.ncbi.nlm.nih.gov/35783166
Autor:
Ramanarayanan Krishnamurthy, Jay W. Haynes, Martin C, Loren Dean Williams, Nicholas V. Hud, Luke J. Leman, Bradley T. Burcar, Anton S. Petrov, Moran Frenkel-Pinter
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance One of the long-standing questions in origins-of-life research centers on how the proteinaceous side chains and the protein backbone were selected during the earliest phases of evolution. Here we have studied oligomerization reactions of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca6baa07b887d154096caccbe4d0769
https://doi.org/10.1073/pnas.1904849116
https://doi.org/10.1073/pnas.1904849116
Autor:
Moran Frenkel-Pinter, Marcos Bouza, Facundo M. Fernández, Luke J. Leman, Loren Dean Williams, Nicholas V. Hud, Aikomari Guzman-Martinez
Publikováno v:
Nature communications. 13(1)
It is widely assumed that the condensation of building blocks into oligomers and polymers was important in the origins of life. High activation energies, unfavorable thermodynamics and side reactions are bottlenecks for abiotic peptide formation. All
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbdee4e7ae27ade919fb186537e5c9ae
https://pubmed.ncbi.nlm.nih.gov/35562173
https://pubmed.ncbi.nlm.nih.gov/35562173