Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Luke J. Engelking"'
Autor:
Albert G. Linden, Shili Li, Hwa Y. Choi, Fei Fang, Masashi Fukasawa, Kosaku Uyeda, Robert E. Hammer, Jay D. Horton, Luke J. Engelking, Guosheng Liang
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 475-487 (2018)
Lipogenesis in liver is highest in the postprandial state; insulin activates SREBP-1c, which transcriptionally activates genes involved in FA synthesis, whereas glucose activates carbohydrate-responsive element-binding protein (ChREBP), which activat
Externí odkaz:
https://doaj.org/article/d01ebb180e1f41a7b9bb032aaf9d21a3
Cholesterol auxotrophy and intolerance to ezetimibe in mice with SREBP-2 deficiency in the intestine
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 10, Pp 1988-1998 (2017)
SREBP-2 activates transcription of all genes needed for cholesterol biosynthesis. To study SREBP-2 function in the intestine, we generated a mouse model (Vil-BP2−/−) in which Cre recombinase ablates SREBP-2 in intestinal epithelia. Intestines of
Externí odkaz:
https://doaj.org/article/4d29a3d8c88d4be09361173ebe9f2d4a
Autor:
Matthew R. McFarlane, Mary Jo Cantoria, Albert G. Linden, Brandon A. January, Guosheng Liang, Luke J. Engelking
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 8, Pp 1560-1571 (2015)
SREBP cleavage-activating protein (Scap) is an endoplasmic reticulum membrane protein required for cleavage and activation of sterol regulatory element-binding proteins (SREBPs), which activate the transcription of genes in sterol and fatty acid bios
Externí odkaz:
https://doaj.org/article/59f7ab0a23d04fb9ae3d437573e7459f
Blockade of cholesterol absorption by ezetimibe reveals a complex homeostatic network in enterocytes
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 7, Pp 1359-1368 (2012)
Enterocyte cholesterol homeostasis reflects aggregated rates of sterol synthesis, efflux, and uptake from plasma and gut lumen. Cholesterol synthesis and LDL uptake are coordinately regulated by sterol regulatory element-binding proteins (SREBP), whe
Externí odkaz:
https://doaj.org/article/3851c7fc56ca423ba9de9f5ce6f162d0
Autor:
Yingfeng Deng, Zhuzhen Zhang, Shangang Zhao, Qingzhang Zhu, May-Yun Wang, Laurent Gautron, Yi Zhu, Zhenzhen Zi, Philipp E. Scherer, Shiuhwei Chen, Jan-Bernd Funcke, Prithvi Raj, Clair Crewe, Christine M. Kusminski, Charlotte E. Lee, Luke J. Engelking, Alexandra L. Ghaben, Ruth Gordillo, Na Li, Leon G. Straub, Yu An
Publikováno v:
Cell Metab
Iron overload is positively associated with diabetes risk. However, the role of iron in adipose tissue remains incompletely understood. Here, we report that transferrin-receptor-1-mediated iron uptake is differentially required for distinct subtypes
Publikováno v:
Seminars in Cell & Developmental Biology. 81:98-109
Sterol regulatory element-binding proteins (SREBPs), master transcriptional regulators of cholesterol and fatty acid synthesis, have been found to contribute to a diverse array of cellular processes. In this review, we focus on genetically engineered
Autor:
Shili Li, Hwa Y. Choi, Albert G. Linden, Masashi Fukasawa, Luke J. Engelking, Robert E. Hammer, Fei Fang, Kosaku Uyeda, Guosheng Liang, Jay D. Horton
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 475-487 (2018)
Journal of Lipid Research
Journal of Lipid Research
Lipogenesis in liver is highest in the postprandial state; insulin activates SREBP-1c, which transcriptionally activates genes involved in FA synthesis, whereas glucose activates carbohydrate-responsive element-binding protein (ChREBP), which activat
Autor:
Andrew D. Nguyen, James Brugarolas, Russell A. DeBose-Boyd, Youngah Jo, Seonghwan Hwang, Luke J. Engelking
Publikováno v:
Journal of Biological Chemistry. 292:9382-9393
Cholesterol synthesis is a highly oxygen-consuming process. As such, oxygen deprivation (hypoxia) limits cholesterol synthesis through incompletely understood mechanisms mediated by the oxygen-sensitive transcription factor hypoxia-inducible factor 1
Autor:
Yanchao Xu, Luke J. Engelking
Publikováno v:
The FASEB Journal. 34:1-1
Autor:
Luke J. Engelking, Mary Jo Cantoria, Guosheng Liang, Albert G. Linden, Matthew R. McFarlane, Brandon A. January
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 8, Pp 1560-1571 (2015)
SREBP cleavage-activating protein (Scap) is an endoplasmic reticulum membrane protein required for cleavage and activation of sterol regulatory element-binding proteins (SREBPs), which activate the transcription of genes in sterol and fatty acid bios