Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Luke J Alderwick"'
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213713 (2019)
Tuberculosis (TB) is an infectious bacterial disease that kills approximately 1.3 million people every year. Despite global efforts to reduce both the incidence and mortality associated with TB, the emergence of drug resistant strains has slowed any
Externí odkaz:
https://doaj.org/article/e3177294040b4e42b8c051f238a6a6ed
Autor:
Joanna Bacon, Luke J Alderwick, Jon A Allnutt, Evelina Gabasova, Robert Watson, Kim A Hatch, Simon O Clark, Rose E Jeeves, Alice Marriott, Emma Rayner, Howard Tolley, Geoff Pearson, Graham Hall, Gurdyal S Besra, Lorenz Wernisch, Ann Williams, Philip D Marsh
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87329 (2014)
A key feature of Mycobacterium tuberculosis is its ability to become dormant in the host. Little is known of the mechanisms by which these bacilli are able to persist in this state. Therefore, the focus of this study was to emulate environmental cond
Externí odkaz:
https://doaj.org/article/c11cea27e6004c5da7415a8a6a12a1b4
Autor:
Sudagar S Gurcha, Veeraraghavan Usha, Jonathan A G Cox, Klaus Fütterer, Katherine A Abrahams, Apoorva Bhatt, Luke J Alderwick, Robert C Reynolds, Nicholas J Loman, VijayaShankar Nataraj, Carlos Alemparte, David Barros, Adrian J Lloyd, Lluis Ballell, Judith V Hobrath, Gurdyal S Besra
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113568 (2014)
The human pathogen Mycobacterium tuberculosis is the causative agent of pulmonary tuberculosis (TB), a disease with high worldwide mortality rates. Current treatment programs are under significant threat from multi-drug and extensively-drug resistant
Externí odkaz:
https://doaj.org/article/d85fbdf303054892bbf5d1a8ee379a42
Autor:
Michael J Capeness, Carey Lambert, Andrew L Lovering, Rob Till, Kaoru Uchida, Roy Chaudhuri, Luke J Alderwick, David J Lee, David Swarbreck, Susan Liddell, Shin-Ichi Aizawa, Renee Elizabeth Sockett
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e79759 (2013)
Bdellovibrio bacteriovorus are facultatively predatory bacteria that grow within gram-negative prey, using pili to invade their periplasmic niche. They also grow prey-independently on organic nutrients after undergoing a reversible switch. The nature
Externí odkaz:
https://doaj.org/article/31be121a47f64b5a91aab84971bc1835
Autor:
Luke J Alderwick, Georgina S Lloyd, Hemza Ghadbane, John W May, Apoorva Bhatt, Lothar Eggeling, Klaus Fütterer, Gurdyal S Besra
Publikováno v:
PLoS Pathogens, Vol 7, Iss 2, p e1001299 (2011)
The D-arabinan-containing polymers arabinogalactan (AG) and lipoarabinomannan (LAM) are essential components of the unique cell envelope of the pathogen Mycobacterium tuberculosis. Biosynthesis of AG and LAM involves a series of membrane-embedded ara
Externí odkaz:
https://doaj.org/article/5c240e7d1b9f44d18f2a6cec2df97e40
Publikováno v:
The Cell Surface, Vol 8, Iss , Pp 100088- (2022)
Mycobacterium tuberculosis causes the disease tuberculosis and affects a third of the world’s population. The recent COVID-19 pandemic exacerbated the situation with a projected 27% increase in tuberculosis related deaths. M. tuberculosis has an el
Externí odkaz:
https://doaj.org/article/494bca92317d4816a06d8899f7c5acd9
Publikováno v:
Cell surface (Amsterdam, Netherlands). 8
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3708-3719 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
Mycobacterium tuberculosis is the causative agent of TB and was estimated to cause 1.4 million death in 2019, alongside 10 million new infections. Drug resistance is a growing issue, with multi-drug resistant infections repres
Mycobacterium tuberculosis is the causative agent of TB and was estimated to cause 1.4 million death in 2019, alongside 10 million new infections. Drug resistance is a growing issue, with multi-drug resistant infections repres
Autor:
Joanna Bacon, Charlotte L. Hendon-Dunn, Thomas Keating, Jon C. Allnutt, Luke J. Alderwick, Samuel Lethbridge, Stephen Thomas, Stephen Taylor
Publikováno v:
The Cell Surface, Vol 7, Iss, Pp 100065-(2021)
The Cell Surface
The Cell Surface
The development of new vaccines for TB needs to be underpinned by an understanding of both the molecular and cellular mechanisms of host-pathogen interactions and how the immune response can be modulated to achieve protection from disease. Complement
Autor:
Caitlin Thornton, Christopher McCabe, Katie Brookes, Kristien Boelaert, Alice Fletcher, Luke J. Alderwick, Martin L. Read, Vicki Smith, Hannah Nieto, Ling Zha
Publikováno v:
Nuclear medicine communications. 42(5)