Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Luke J, Janssen"'
Autor:
Paul F. Lebeau, Jae Hyun Byun, Khrystyna Platko, Paul Saliba, Matthew Sguazzin, Melissa E. MacDonald, Guillaume Paré, Gregory R. Steinberg, Luke J. Janssen, Suleiman A. Igdoura, Mark A. Tarnopolsky, S. R. Wayne Chen, Nabil G. Seidah, Jakob Magolan, Richard C. Austin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Caffeine may reduce cardiovascular disease risk, but the underlying mechanisms for these effects are incompletely understood. Here the authors report that caffeine inhibits the activation of the transcription factor SREBP2 to promote LDLc clearance t
Externí odkaz:
https://doaj.org/article/6733f73670aa4d5a807867eed2c293ea
Autor:
Daniela Riccardi, Jeremy P.T. Ward, Polina L. Yarova, Luke J. Janssen, Tak Hong Lee, Sun Ying, Chris J. Corrigan
In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the likely benefits of topical therapy of asthma with negative al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5d1929f30fcb786845d286667a1b18
https://orca.cardiff.ac.uk/id/eprint/147559/1/ERJ-02103-2021.R2_Proof_hi.pdf
https://orca.cardiff.ac.uk/id/eprint/147559/1/ERJ-02103-2021.R2_Proof_hi.pdf
Autor:
Luke J. Janssen
Publikováno v:
Perspectives on Science and Christian Faith. 73:13-22
Humanity has survived many waves of attacks mounted by microscopic agents which we cannot see but which have left millions of our species dead, and hundreds of millions more enduring a great deal of pain and suffering, even life-long dysfunction. Pan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd69e2edb41e7cdee336dc3f519692be
https://doi.org/10.56315/pscf3-21janssen
https://doi.org/10.56315/pscf3-21janssen
Publikováno v:
Cells, Vol 10, Iss 157, p 157 (2021)
Cells
Volume 10
Issue 1
Cells
Volume 10
Issue 1
The magnitude of eosinophil mobilization into respiratory tissues drives the severity of inflammation in several airway diseases. In classical models of leukocyte extravasation, surface integrins undergo conformational switches to high-affinity state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd033e28665e93c5b165ca6537c8f4a
https://www.mdpi.com/2073-4409/10/1/157
https://www.mdpi.com/2073-4409/10/1/157
Autor:
Luke J Janssen
Publikováno v:
Canadian Respiratory Journal, Vol 5, Iss 6, Pp 491-498 (1998)
Calcium plays a central role in the activation of many cellular processes, including the most relevant end-point in airway smooth muscle physiology: contraction. For this reason, the cytosolic concentration of calcium is tightly controlled by an elab
Externí odkaz:
https://doaj.org/article/e1a071d5948d486799a73d25db3cd23d
Autor:
Luke J Janssen
Publikováno v:
Canadian Respiratory Journal, Vol 4, Iss 1, Pp 13-20 (1997)
Electrophysiological and pharmacological techniques were used to characterize the membrane conductance changes underlying spasmogen-evoked depolarization in airway smooth muscle (ASM). Changes included a transient activation of chloride ion channels
Externí odkaz:
https://doaj.org/article/181d3d66e0974555a16aa562ad2d83bc
Autor:
Paul F, Lebeau, Jae Hyun, Byun, Khrystyna, Platko, Paul, Saliba, Matthew, Sguazzin, Melissa E, MacDonald, Guillaume, Paré, Gregory R, Steinberg, Luke J, Janssen, Suleiman A, Igdoura, Mark A, Tarnopolsky, S R, Wayne Chen, Nabil G, Seidah, Jakob, Magolan, Richard C, Austin
Publikováno v:
Nature communications. 13(1)
Evidence suggests that caffeine (CF) reduces cardiovascular disease (CVD) risk. However, the mechanism by which this occurs has not yet been uncovered. Here, we investigated the effect of CF on the expression of two bona fide regulators of circulatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b174aff809059ae62c5c35071e93c4fe
https://pubmed.ncbi.nlm.nih.gov/35140212
https://pubmed.ncbi.nlm.nih.gov/35140212
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 312:L510-L519
It is now clear that in addition to activating several complex kinase pathways (Smad, MAP kinase, PI3 kinase), TGFβ also acts by elevating cytosolic Ca2+ concentration within human pulmonary fibroblasts. Ca2+/calmodulin-dependent protein kinase II (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d37aed34b50625e867566ae705d5c8a
https://doi.org/10.1152/ajplung.00084.2016
https://doi.org/10.1152/ajplung.00084.2016
Publikováno v:
Journal of leukocyte biologyREFERENCES. 108(1)
The regulatory processes involved in eosinophil trafficking into tissues are poorly understood; therefore, it is crucial to elucidate these mechanisms to advance the quality of clinical care for patients with eosinophil-mediated diseases. The complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::397bcf8a6e969916027da57ca3b79785
https://pubmed.ncbi.nlm.nih.gov/32349177
https://pubmed.ncbi.nlm.nih.gov/32349177
Autor:
Subhendu, Mukherjee, Wei, Sheng, Alexander, Michkov, Krishna, Sriarm, Rui, Sun, Anna, Dvorkin-Gheva, Paul A, Insel, Luke J, Janssen
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
We have shown that calcium (Ca(2+)) oscillations in human pulmonary fibroblasts (HPFs) contribute to profibrotic effects of transforming growth factor-β (TGF-β) and that disruption of these oscillations blunts features of pulmonary fibrosis. Prosta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b5e9177f8bfeff5897d168a20ef71bc
https://pubmed.ncbi.nlm.nih.gov/30758990
https://pubmed.ncbi.nlm.nih.gov/30758990