Zobrazeno 1 - 10
of 158
pro vyhledávání: '"Luke I Szweda"'
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77280 (2013)
Cardiac function depends on the ability to switch between fatty acid and glucose oxidation for energy production in response to changes in substrate availability and energetic stress. In obese and diabetic individuals, increased reliance on fatty aci
Externí odkaz:
https://doaj.org/article/e49117fb8c8046ecb37f3c81ebc75e95
Autor:
Caroline S Kinter, Jillian M Lundie, Halee Patel, Paul M Rindler, Luke I Szweda, Michael Kinter
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e50016 (2012)
The loading of macrophages with oxidized low density lipoprotein (LDL) is a key part of the initiation and progression of atherosclerosis. Oxidized LDL contains a wide ranging set of toxic species, yet the molecular events that allow macrophages to w
Externí odkaz:
https://doaj.org/article/2aae578d3a9648ef8a5e1bd179147ea8
Publikováno v:
Antioxidants, Vol 12, Iss 3, p 756 (2023)
Obesity affects a growing fraction of the population and is a risk factor for type 2 diabetes and cardiovascular disease. Even in the absence of hypertension and coronary artery disease, type 2 diabetes can result in a heart disease termed diabetic c
Externí odkaz:
https://doaj.org/article/1f04247ef1df421aa448d0b09dee0016
Autor:
Melissa A. Fath, Douglas R. Spitz, Brian J. Smith, Luke I. Szweda, Anna M. Button, Kaleigh E. Lindholm, Kristin E. Brandt, John M. Buatti, Sudershan K. Bhatia, Bryan G. Allen
Supplementary Figure 1 - PDF file 911K, Mouse weights
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10fdab660ec81c171d67c40286ed28cf
https://doi.org/10.1158/1078-0432.22448177
https://doi.org/10.1158/1078-0432.22448177
Autor:
Melissa A. Fath, Douglas R. Spitz, Brian J. Smith, Luke I. Szweda, Anna M. Button, Kaleigh E. Lindholm, Kristin E. Brandt, John M. Buatti, Sudershan K. Bhatia, Bryan G. Allen
Supplementary Figure Legend - PDF file 71K, Supplementary Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288e9b6bfa6ddebe4725b5bef10de105
https://doi.org/10.1158/1078-0432.22448171
https://doi.org/10.1158/1078-0432.22448171
Autor:
Melissa A. Fath, Douglas R. Spitz, Brian J. Smith, Luke I. Szweda, Anna M. Button, Kaleigh E. Lindholm, Kristin E. Brandt, John M. Buatti, Sudershan K. Bhatia, Bryan G. Allen
Purpose: Ketogenic diets are high in fat and low in carbohydrates as well as protein which forces cells to rely on lipid oxidation and mitochondrial respiration rather than glycolysis for energy metabolism. Cancer cells (relative to normal cells) are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4852e738bb49e8f440f4b1f2ed8966ce
https://doi.org/10.1158/1078-0432.c.6521330.v1
https://doi.org/10.1158/1078-0432.c.6521330.v1
Autor:
Kimberly L. James, Luis A. Ríos-Hernández, Neil Q. Wofford, Housna Mouttaki, Jessica R. Sieber, Cody S. Sheik, Hong H. Nguyen, Yanan Yang, Yongming Xie, Jonathan Erde, Lars Rohlin, Elizabeth A. Karr, Joseph A. Loo, Rachel R. Ogorzalek Loo, Gregory B. Hurst, Robert P. Gunsalus, Luke I. Szweda, Michael J. McInerney
Publikováno v:
mBio, Vol 7, Iss 4 (2016)
ABSTRACT Syntrophus aciditrophicus is a model syntrophic bacterium that degrades key intermediates in anaerobic decomposition, such as benzoate, cyclohexane-1-carboxylate, and certain fatty acids, to acetate when grown with hydrogen-/formate-consumin
Externí odkaz:
https://doaj.org/article/d1dab5dbda50462a851bf92528d0875e
Autor:
Chukwuemeka George Anene-Nzelu, Michael Kinter, Hesham A. Sadek, Jainy J. Savla, Salim Abdisalaam, Luke I. Szweda, Abdallah Elnwasany, Roger Foo, Ursa Bezan Petric, Ana Helena Macedo Pereira, Ivan Menendez-Montes, Mohammed Kanchwala, Chalermchai Khemtong, Yuji Nakada, Wilson Lek Wen Tan, Shujuan Li, Craig R. Malloy, Mahmoud S. Ahmed, Kaitlyn M. Eckert, Ngoc Uyen Nhi Nguyen, A. Dean Sherry, Emily L Ensley, Aroumougame Asaithamby, Gaurav Sharma, Gonçalo Vale, Chao Xing, Linzhang Huang, Matthew A. Mitsche, Nicholas T. Lam, Philip W. Shaul, Alisson C. Cardoso, Joseph A. Hill, Waleed M. Elhelaly, Jeffrey G. McDonald
Publikováno v:
Nature Metabolism. 2:167-178
The neonatal mammalian heart is capable of regeneration for a brief window of time after birth. However, this regenerative capacity is lost within the first week of life, which coincides with a postnatal shift from anaerobic glycolysis to mitochondri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42c21436855a1b7e902d0de5305b7349
https://doi.org/10.1038/s42255-020-0169-x
https://doi.org/10.1038/s42255-020-0169-x
Autor:
Ivan Menendez-Montes, Zhaoning Wang, Alisson C. Cardoso, Andrew Lemoff, Miao Cui, Mohammad Goodarzi, John M. Shelton, Ngoc Uyen Nhi Nguyen, Ana Helena Macedo Pereira, Shujuan Li, Shah R. Ali, Feng Xiao, Waleed M. Elhelaly, Nicholas T. Lam, Abdallah Elnwasany, Michael Kinter, Hesham A. Sadek, Wataru Kimura, Suwannee Thet, Luke I. Szweda
To identify non-cell-autonomous effectors of cardiomyocyte mitosis, we analyzed a transcriptomic screen of regenerating and non-regenerating neonatal hearts for differentially-expressed secreted proteins – which we hypothesized could include candid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::868ea862c7969bb49863246fb5285e55
https://doi.org/10.1101/2021.09.16.460522
https://doi.org/10.1101/2021.09.16.460522
Autor:
Nicholas T. Lam, Hesham A. Sadek, Salim Abdisalaam, Shibani Mukherjee, Aroumougame Asaithamby, Ivan Menendez-Montes, Feng Xiao, Luke I. Szweda
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The inability of adult mammalian cardiomyocytes to proliferate underpins the development of heart failure following myocardial injury. Although the newborn mammalian heart can spontaneously regenerate for a short period of time after birth, this abil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5a79b795cd802965f90e4c63fd11d2
https://doi.org/10.1073/pnas.2101674118
https://doi.org/10.1073/pnas.2101674118