Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Luke H. Stockwin"'
Autor:
Luke H. Stockwin
Publikováno v:
PeerJ, Vol 8, p e9394 (2020)
Alveolar soft-part sarcoma (ASPS) is an extremely rare malignancy characterized by the unbalanced translocation der(17)t(X;17)(p11;q25). This translocation generates a fusion protein, ASPL-TFE3, that drives pathogenesis through aberrant transcription
Externí odkaz:
https://doaj.org/article/ceedf38c330a4d24bdd817c6a16dd874
Autor:
Shweta Singh, Thorunn Rafnar, Bjorg Gudmundsdottir, Kimberly D. Klarmann, Yang Du, Lei Sun, Vincenzo Coppola, Jonathan R. Keller, Leifur Thorsteinsson, Nhu Nguyen, John F. Tisdale, Lino Tessarollo, Luke H. Stockwin, Kristbjorn O. Gudmundsson, Sveinn Vidar Gudmundsson, Olafur E. Sigurjonsson, Satyendra K. Singh
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3236-3248 (2018)
Cell reports
Cell reports
SUMMARY Fetal globin genes are transcriptionally silenced during embryogenesis through hemoglobin switching. Strategies to derepress fetal globin expression in the adult could alleviate symptoms in sickle cell disease and β-thalassemia. We identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bacca93131d171d06be866fb5d7ee2c0
https://doi.org/10.1016/j.celrep.2018.05.043
https://doi.org/10.1016/j.celrep.2018.05.043
Autor:
Luis E. Romero, Kaitlyn Arthur, Robin D. Harrington, Justine N. McCutcheon, Brandie A. Fullmer, Gloryvee Rivera, Li Chen, Savanna Styers, Matthew R. Murphy, Lindsay Dutko, Rajesh Patidar, Kelly Benauer, Alyssa K. Chapman, Marion Gibson, Abigail Walke, Carrie Bonomi, Vishnuprabha R. Kannan, Luke H. Stockwin, Paul Williams, Tomas Vilimas, Kelly Dougherty, Amanda Peach, Jenna Moyer, Biswajit Das, Michelle M. Gottholm-Ahalt, Peng Wang, James H. Doroshow, Nikitha Nair, Erin Cantu, Kelsey A. Conley, Melinda G. Hollingshead, Anna Wade, Thomas Forbes, Anna J. Lee Fong, Kevin Plater, Joseph P. Geraghty, Mariah Baldwin, Dianne L. Newton, Yvonne A. Evrard, Shahanawaz Jiwani, Chris Karlovich, Michael Mullendore
Publikováno v:
Cancer Research. 80:3916-3916
Background: The National Cancer Institute (NCI) has developed a Patient-Derived Models Repository (PDMR; https://pdmr.cancer.gov) of preclinical models including patient-derived xenografts (PDX), organoids (PDOrg) and patient-derived cell cultures (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c92ac8998cba27fe115123a1e2978aa
https://doi.org/10.1158/1538-7445.am2020-3916
https://doi.org/10.1158/1538-7445.am2020-3916
Autor:
Debbie Trail, Abigail Walke, Petreena Campbell, Marion Gibson, Carrie Bonomi, Kelly Dougherty, Luke H. Stockwin, Savanna Styers, Matthew R. Murphy, Yvonne A. Evrard, Annamaria Rapisarda, Jenna Moyer, Lara H. El Touny, James H. Doroshow, Tara Grinnage-Pulley, Erik Harris, Joseph P. Geraghty, John Mark Carter, Kevin Plater, Michael Mullendore, Tiffanie Chase, Nathan P. Coussens, Michelle M. Gottholm-Ahalt, John Connelly, Dianne L. Newton, Beverly A. Teicher, Ralph E. Parchment, Anna Wade, Mariah Baldwin, Curtis Hose, Kaitlyn Arthur, Melinda G. Hollingshead, Howard Stotler
Publikováno v:
Cancer Research. 80:3913-3913
Cancer organoids are heterogeneous 3D cellular clusters with complexities that mimic some characteristics of tumors in situ. Thus, assays performed with cancer organoids might enable better predictions of in vivo drug responses than those performed w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cecbb88dcee7f0ddcb0f7a0d048ae30
https://doi.org/10.1158/1538-7445.am2020-3913
https://doi.org/10.1158/1538-7445.am2020-3913
Autor:
Jenna Moyer, Howard Stotler, James H. Doroshow, Tom Walsh, Lily Chen, Abigail Walke, Mike Mullendore, Matt Murphy, Tara Grinnage-Pulley, Luke H. Stockwin, Marion Gibson, Yvonne A. Evrard, John Mark Carter, Wiem Lassoued, Suzanne Borgel, Carrie Bonomi, Kelly Dougherty, Kevin Plater, Biswajit Das, Raymond Divelbiss, Joe Geraghty, Vivekananda Datta, Nikki E. Craig, Emily Delaney, Marianne Radzyminski, Alice P. Chen, Kaitlyn Arthur, Mariah Baldwin, Rajesh Patidar, Dianne L. Newton, Sergio Y. Alcoser, Debbie Trail, Kyle Georgius, Shahanawaz Jiwani, Chris Karlovich, Tiffany Chase, Candace Mallow, Mallorie Morris, Sierra Hoffman, Thomas P. Forbes, P. Mickey Williams, Nicki Scott, Savanna Styers, Anna Wade, Jesse Stottlemyer, Chelsea McGlynn, Tomas Vilimas, Melinda G. Hollingshead, Michelle M. Gottholm-Ahalt, Kelly Hedger
Publikováno v:
Cancer Research. 79:4524-4524
The National Cancer Institute (NCI) has developed a Patient-Derived Models Repository (PDMR) comprised of quality-controlled, early-passage, clinically-annotated patient-derived tumor xenografts (PDXs), in vitro tumor cell cultures (PDCs), cancer ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d223bfc66aa20787b6d643f9546b2e9
https://doi.org/10.1158/1538-7445.am2019-4524
https://doi.org/10.1158/1538-7445.am2019-4524
Autor:
Bethanie L. Morrison, Dianne L. Newton, Melinda G. Hollingshead, Suzanne Borgel, Michael E. Mullendore, Luke H. Stockwin
Publikováno v:
Cancer Medicine
Oxyphenisatin (3,3-bis(4-hydroxyphenyl)-1H-indol-2-one) and several structurally related molecules have been shown to have in vitro and in vivo antiproliferative activity. This study aims to confirm and extend mechanistic studies by focusing on oxyph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9609e69f96fdfa464a7bd595a3bf0bcb
http://europepmc.org/articles/PMC3892800
http://europepmc.org/articles/PMC3892800
Autor:
Luke H. Stockwin, Trevor Glaros, Michael E. Mullendore, Bethanie L. Morrison, Brian J. Smith, Dianne L. Newton
Publikováno v:
Cancer Chemotherapy and Pharmacology. 70:207-212
To establish whether NSC80467, a novel fused naphthquinone imidazolium, has a similar spectrum of activity to the well-characterized "survivin suppressant" YM155 and to extend mechanistic studies for this structural class of agent.NSC80467 and YM155
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04c644abd4a1296196c33493e4ee597
https://doi.org/10.1007/s00280-012-1868-0
https://doi.org/10.1007/s00280-012-1868-0
Publikováno v:
Expert Review of Proteomics. 8:483-494
The response to extracellular stimuli often alters the phosphorylation state of plasma membrane- associated proteins. In this regard, generation of a comprehensive membrane phosphoproteome can significantly enhance signal transduction and drug mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5da8291ed7a15e8f9f35fca75942ba72
https://doi.org/10.1586/epr.11.40
https://doi.org/10.1586/epr.11.40
Autor:
Jung Ho Jun, Raymond Divelbiss, Dianne L. Newton, Luke H. Stockwin, Chad N. Hancock, Melinda G. Hollingshead, Bingnan Han, Sanjay V. Malhotra
Publikováno v:
Free Radical Biology and Medicine. 50:110-121
In this study, a Cu(2+) chelate of the novel thiosemicarbazone NSC 689534 was evaluated for in vitro and in vivo anti-cancer activity. Results demonstrated that NSC 689534 activity (low micromolar range) was enhanced four- to fivefold by copper chela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c96ff8d23acea8034027424a21ca553
https://doi.org/10.1016/j.freeradbiomed.2010.10.696
https://doi.org/10.1016/j.freeradbiomed.2010.10.696
Autor:
Yvonne A. Evrard, Michelle M. Gottholm Ahalt, Sergio . Y. Alcoser, Kaitlyn Arthur, Mariah Baldwin, Linda L. Blumenauer, Carrie Bonomi, Suzanne Borgel, Elizabeth Bradtke, Corinne Camalier, John Carter, Tiffanie Chase, Alice Chen, Lily Chen, Donna W. Coakley, Nicole E. Craig, Biswajit Das, Vivekananda Datta, Jordyn Davidson, Margaret R. DeFreytas, Emily Delaney, Michelle A. Eugeni, Raymond Divelbiss, Palmer Fliss, Thomas Forbes, Marion Gibson, Tara Grinnage-Pulley, Sierra Hoffman, Lilia Ileva, Paula Jacobs, Franklyn Jimenez, Joseph Kalen, Catherine Karangwa, Chris Karlovich, Candace Mallow, Chelsea McGlynn, Jenna E. Moyer, Michael Mullendore, Dianne L. Newton, Nimit Patel, Rajesh Patidar, Kevin Plater, Marianne Radzyminski, Lisa Riffle, Larry Rubinstein, Luke H. Stockwin, Mickey Williams, Melinda G. Hollingshead, James H. Doroshow
Publikováno v:
Cancer Research. 78:986-986
The National Cancer Institute (NCI) has developed a Patient-Derived Models Repository (PDMR) comprised of quality-controlled, early-passage, clinically-annotated patient-derived xenografts (PDXs) to serve as a resource for public-private partnerships
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23a742fdcc7a3fb89953ea67c7217998
https://doi.org/10.1158/1538-7445.am2018-986
https://doi.org/10.1158/1538-7445.am2018-986