Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Luke H. Rhym"'
Autor:
Tingting Jiang, Jordana M. Henderson, Kevin Coote, Yi Cheng, Hillary C. Valley, Xiao-Ou Zhang, Qin Wang, Luke H. Rhym, Yueying Cao, Gregory A. Newby, Hermann Bihler, Martin Mense, Zhiping Weng, Daniel G. Anderson, Anton P. McCaffrey, David R. Liu, Wen Xue
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Cas9 base editors are promising tools for correcting pathogenic single nucleotide mutations. Here the authors chemically modify mRNA encoding the editor and the gRNA to enhance editing and broaden its application.
Externí odkaz:
https://doaj.org/article/063c642bedca45fb8d0878850da6e48f
Publikováno v:
Nature Biomedical Engineering.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00a7c98640fdcccf3400b129f021fc36
https://doi.org/10.1038/s41551-023-01030-4
https://doi.org/10.1038/s41551-023-01030-4
Autor:
Gregory A. Newby, Luke H. Rhym, Hermann Bihler, Zhiping Weng, Martin Mense, Tingting Jiang, Wen Xue, Xiao-Ou Zhang, Y. Cheng, Jordana M. Henderson, H. Valley, Yueying Cao, Anton P. McCaffrey, Daniel G. Anderson, David R. Liu, Qin Wang, Kevin Coote
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
CRISPR-Cas9-associated base editing is a promising tool to correct pathogenic single nucleotide mutations in research or therapeutic settings. Efficient base editing requires cellular exposure to levels of base editors that can be difficult to attain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb61cea1d36ee5309fa0957875fb1f9f
https://doaj.org/article/063c642bedca45fb8d0878850da6e48f
https://doaj.org/article/063c642bedca45fb8d0878850da6e48f
Autor:
Wheaton Little, Charles Campbell, Daniel G. Anderson, Ryan Reshke, Piotr S. Kowalski, Luke H. Rhym, My Tran Trung, James A. Taylor, Derrick Gibbings, Alexandre Savard, Huishan Guo
Publikováno v:
Nature Biomedical Engineering. 4:52-68
A small percentage of the short interfering RNA (siRNA) delivered via passive lipid nanoparticles and other delivery vehicles reaches the cytoplasm of cells. The high doses of siRNA and delivery vehicle that are thus required to achieve therapeutic o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e9961722903992536769da4ace6564
https://doi.org/10.1038/s41551-019-0502-4
https://doi.org/10.1038/s41551-019-0502-4
Autor:
Luke H. Rhym, Daniel G. Anderson
Publikováno v:
Med (New York, N.Y.). 3(3)
RNA nanomedicines present a promising class of therapeutics, with broad applications in protein replacement therapy, gene editing, immunotherapy, and vaccines, owing to their versatility and precise nature. Although recent years have seen dramatic im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cfb8433bb4afc3be2c4e833bf281a4
https://pubmed.ncbi.nlm.nih.gov/35590191
https://pubmed.ncbi.nlm.nih.gov/35590191
Autor:
Luke H. Rhym, Balkrishen Bhat, Umberto Capasso Palmiero, Asha K. Patel, Daniel G. Anderson, James C. Kaczmarek, Frank Derosa, Michael W. Heartlein
Non-viral vectors offer the potential to deliver nucleic acids including mRNA and DNA into cells in vivo. However, designing materials that effectively deliver to target organs and then to desired compartments within the cell remains a challenge. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18aa9b58bdd4a90ca6af0d388ca1368f
http://hdl.handle.net/10044/1/90329
http://hdl.handle.net/10044/1/90329
Autor:
Chun-Qing Song, Luke H. Rhym, Tingting Jiang, Lukas E. Dow, Jordan L. Doman, Wen Xue, Michelle Richter, Emma M Schatoff, Maria Paz Zafra, Lihua Julie Zhu, Hao Yin, Yueying Cao, David R. Liu, Daniel G. Anderson, Luke W. Koblan
Publikováno v:
Nature Biomedical Engineering. 4:125-130
In contrast to traditional CRISPR–Cas9 homology-directed repair, base editing can correct point mutations without supplying a DNA-repair template. Here we show in a mouse model of tyrosinaemia that hydrodynamic tail-vein injection of plasmid DNA en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a8b7929dd3c0b04e94cd68a37d55ed1
https://doi.org/10.1038/s41551-019-0357-8
https://doi.org/10.1038/s41551-019-0357-8
Autor:
Frank Derosa, Kevin J. Kauffman, Daniel G. Anderson, Michael W. Heartlein, Jason L. Andresen, Owen S. Fenton, Manhao D. Zeng, Luke H. Rhym, Rebecca L. McClellan, James C. Kaczmarek
Publikováno v:
Angew Chem Int Ed Engl
RNAs are a promising class of therapeutics given their ability to regulate protein concentrations at the cellular level. Developing safe and effective strategies to deliver RNAs remains important for realizing their full clinical potential. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::038555ced0ebd515c1250a26dfacc71d
https://doi.org/10.1002/anie.201809056
https://doi.org/10.1002/anie.201809056
Autor:
Victor Koteliansky, Kevin J. Kauffman, Stephen Walsh, Roman L. Bogorad, Hao Yin, Qiongqiong Wu, Alicia Oberholzer, Luke H. Rhym, Daniel G. Anderson, Suet-Yan Kwan, Haiwei Mou, Timofei S. Zatsepin, Robert Langer, Esther Mintzer, Mehmet Fatih Bolukbasi, Sneha Suresh, Lihua Julie Zhu, Wen Xue, Chun-Qing Song, Scot A. Wolfe, Junmei Ding
Publikováno v:
Nature Biotechnology. 35:1179-1187
Efficient genome editing with Cas9–sgRNA in vivo has required the use of viral delivery systems, which have limitations for clinical applications. Translational efforts to develop other RNA therapeutics have shown that judicious chemical modificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0306de66ecfbac376b1ad3b1320801d
https://doi.org/10.1038/nbt.4005
https://doi.org/10.1038/nbt.4005
Autor:
Daniel G. Anderson, Tatiana Prikazchikova, Timofei S. Zatsepin, Luke H. Rhym, Dominique Leboeuf, Konstantin I. Piatkov, Tatiana O. Abakumova
Publikováno v:
Mol Ther
Elsevier
Elsevier
The N-degron pathway is an emerging target for anti-tumor therapies, because of its capacity to positively regulate many hallmarks of cancer, including angiogenesis, cell proliferation, motility, and survival. Thus, inhibition of the N-degron pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::becf44dfa14734a66b8f2a91a295c1ff
https://pubmed.ncbi.nlm.nih.gov/32087767
https://pubmed.ncbi.nlm.nih.gov/32087767