Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Luke Freeman"'
Autor:
Florine A. Eggink, Inge C. Van Gool, Alexandra Leary, Pamela M. Pollock, Emma J. Crosbie, Linda Mileshkin, Ekaterina S. Jordanova, Julien Adam, Luke Freeman-Mills, David N. Church, Carien L. Creutzberg, Marco De Bruyn, Hans W. Nijman, Tjalling Bosse
Publikováno v:
OncoImmunology, Vol 6, Iss 2 (2017)
High-risk endometrial cancer (EC) is an aggressive disease for which new therapeutic options are needed. Aims of this study were to validate the enhanced immune response in highly mutated ECs and to explore immune profiles in other EC subgroups. We e
Externí odkaz:
https://doaj.org/article/475adc4ab5f34a48a77118f7a1e7e850
Autor:
Gabriel N. Aughey, Stuart J. Grice, Qing-Ji Shen, Yichi Xu, Chia-Chun Chang, Ghows Azzam, Pei-Yu Wang, Luke Freeman-Mills, Li-Mei Pai, Li-Ying Sung, Jun Yan, Ji-Long Liu
Publikováno v:
Biology Open, Vol 3, Iss 11, Pp 1045-1056 (2014)
The essential metabolic enzyme CTP synthase (CTPsyn) can be compartmentalised to form an evolutionarily-conserved intracellular structure termed the cytoophidium. Recently, it has been demonstrated that the enzymatic activity of CTPsyn is attenuated
Externí odkaz:
https://doaj.org/article/8ac2f8470e1a4573a8bbc4dc84920784
Autor:
Annabelle Lewis, Luke Freeman-Mills, Elisa de la Calle-Mustienes, Rosa María Giráldez-Pérez, Hayley Davis, Emma Jaeger, Martin Becker, Nina C. Hubner, Luan N. Nguyen, Jorge Zeron-Medina, Gareth Bond, Hendrik G. Stunnenberg, Jaime J. Carvajal, Jose Luis Gomez-Skarmeta, Simon Leedham, Ian Tomlinson
Publikováno v:
Cell Reports, Vol 8, Iss 4, Pp 983-990 (2014)
A rare germline duplication upstream of the bone morphogenetic protein antagonist GREM1 causes a Mendelian-dominant predisposition to colorectal cancer (CRC). The underlying disease mechanism is strong, ectopic GREM1 overexpression in the intestinal
Externí odkaz:
https://doaj.org/article/2b9331b1c6724e84b883554db9034ce7
Autor:
David N. Church, Tjalling Bosse, Hans W. Nijman, Vincent T.H.B.M. Smit, Ian P.M. Tomlinson, Carien L. Creutzberg, Paul Klenerman, Elisabeth M. Osse, Cor D. de Kroon, Remi A. Nout, Claire Palles, Marco de Bruyn, Emanuele Marchi, Ellen Stelloo, Luke Freeman-Mills, Florine A. Eggink, Inge C. van Gool
Supplementary table 1. Demographic and clinicopathological characteristics of cases by EC molecular subtype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6752034f63d1767eb80c3211ad8871ac
https://doi.org/10.1158/1078-0432.22459196.v1
https://doi.org/10.1158/1078-0432.22459196.v1
Autor:
David N. Church, Tjalling Bosse, Hans W. Nijman, Vincent T.H.B.M. Smit, Ian P.M. Tomlinson, Carien L. Creutzberg, Paul Klenerman, Elisabeth M. Osse, Cor D. de Kroon, Remi A. Nout, Claire Palles, Marco de Bruyn, Emanuele Marchi, Ellen Stelloo, Luke Freeman-Mills, Florine A. Eggink, Inge C. van Gool
Supplementary table 2. Antigen presentation pathway mutations in TCGA POLE proofreading-mutant ECs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821887c6dfc977e323a1d13b964de578
https://doi.org/10.1158/1078-0432.22459193
https://doi.org/10.1158/1078-0432.22459193
Autor:
David N. Church, Tjalling Bosse, Hans W. Nijman, Vincent T.H.B.M. Smit, Ian P.M. Tomlinson, Carien L. Creutzberg, Paul Klenerman, Elisabeth M. Osse, Cor D. de Kroon, Remi A. Nout, Claire Palles, Marco de Bruyn, Emanuele Marchi, Ellen Stelloo, Luke Freeman-Mills, Florine A. Eggink, Inge C. van Gool
Purpose: Recent studies have shown that 7% to 12% of endometrial cancers are ultramutated due to somatic mutation in the proofreading exonuclease domain of the DNA replicase POLE. Interestingly, these tumors have an excellent prognosis. In view of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::623c3ef4f2a3ebd4fc6ec34df51733cc
https://doi.org/10.1158/1078-0432.c.6524156.v1
https://doi.org/10.1158/1078-0432.c.6524156.v1
Autor:
David N. Church, Tjalling Bosse, Hans W. Nijman, Vincent T.H.B.M. Smit, Ian P.M. Tomlinson, Carien L. Creutzberg, Paul Klenerman, Elisabeth M. Osse, Cor D. de Kroon, Remi A. Nout, Claire Palles, Marco de Bruyn, Emanuele Marchi, Ellen Stelloo, Luke Freeman-Mills, Florine A. Eggink, Inge C. van Gool
Supplementary figure 1. Tumor infiltrating lymphocytes and Crohn's like reaction in POLE- mutant endometrioid endometrial cancers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88cc2061a7577c1c39b8f8abb09fa175
https://doi.org/10.1158/1078-0432.22459214
https://doi.org/10.1158/1078-0432.22459214
Autor:
David N. Church, Tjalling Bosse, Hans W. Nijman, Vincent T.H.B.M. Smit, Ian P.M. Tomlinson, Carien L. Creutzberg, Paul Klenerman, Elisabeth M. Osse, Cor D. de Kroon, Remi A. Nout, Claire Palles, Marco de Bruyn, Emanuele Marchi, Ellen Stelloo, Luke Freeman-Mills, Florine A. Eggink, Inge C. van Gool
Supplementary figure 4. CD20+ and FOXP3+ tumor infiltrate according to EC molecular subtype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf726e6c984532f245201af90cd1580
https://doi.org/10.1158/1078-0432.22459205
https://doi.org/10.1158/1078-0432.22459205
Autor:
David N. Church, Tjalling Bosse, Hans W. Nijman, Vincent T.H.B.M. Smit, Ian P.M. Tomlinson, Carien L. Creutzberg, Paul Klenerman, Elisabeth M. Osse, Cor D. de Kroon, Remi A. Nout, Claire Palles, Marco de Bruyn, Emanuele Marchi, Ellen Stelloo, Luke Freeman-Mills, Florine A. Eggink, Inge C. van Gool
Supplementary figure 2. CD3+ tumor infiltrate according to EC molecular subtype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bfc6da104689eeac7f2d1c6fa0e876
https://doi.org/10.1158/1078-0432.22459211.v1
https://doi.org/10.1158/1078-0432.22459211.v1
Autor:
David N. Church, Tjalling Bosse, Hans W. Nijman, Vincent T.H.B.M. Smit, Ian P.M. Tomlinson, Carien L. Creutzberg, Paul Klenerman, Elisabeth M. Osse, Cor D. de Kroon, Remi A. Nout, Claire Palles, Marco de Bruyn, Emanuele Marchi, Ellen Stelloo, Luke Freeman-Mills, Florine A. Eggink, Inge C. van Gool
Supplementary figure 3. Number of TIA-1+ cytolytic T cells according to molecular subtype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ea494d2dba794c1fce95b5245b0436
https://doi.org/10.1158/1078-0432.22459208.v1
https://doi.org/10.1158/1078-0432.22459208.v1