Výsledky vyhledávání - "Luke F. Peterson"

Akademický článek

Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma

Autor: Harish Potu, Luke F. Peterson, Malathi Kandarpa, Anupama Pal, Hanshi Sun, Alison Durham, Paul W. Harms, Peter C. Hollenhorst, Ugur Eskiocak, Moshe Talpaz, Nicholas J. Donato

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Usp9x is a deubiquitinating enzyme with altered expression in melanoma; however its functional contribution in this context is not clear. Here the authors show that Usp9x regulates the stability of the transcription factor Ets-1 that in turn impacts

Externí odkaz: https://doaj.org/article/e602171c7095415dab7480a2914dff72

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Akademický článek

SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation

Autor: James Ropa, Nirmalya Saha, Hsiangyu Hu, Luke F. Peterson, Moshe Talpaz, Andrew G. Muntean

Publikováno v: Haematologica, Vol 105, Iss 9 (2019)

Epigenetic regulators play a critical role in normal and malignant hematopoiesis. Deregulation, including epigenetic deregulation, of the HOXA gene cluster drives transformation of about 50% of acute myeloid leukemia. We recently showed that the Hist

Externí odkaz: https://doaj.org/article/35da74693efd4340b808549eac762a05

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Data from Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia

Autor: Bruno Calabretta, Marja T. Nevalainen, Pierluigi Porcu, Luke F. Peterson, Alessandro Rambaldi, Orietta Spinelli, Samanta A. Mariani, Patrizia Porazzi, Marco De Dominici, Valentina Minieri

Combining standard cytotoxic chemotherapy with BCR-ABL1 tyrosine kinase inhibitors (TKI) has greatly improved the upfront treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). However, due to the develo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e85594dd3e61d78463c9b5678169ed35
https://doi.org/10.1158/0008-5472.c.6510594.v1

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Data from Targeting CDK6 and BCL2 Exploits the 'MYB Addiction' of Ph+ Acute Lymphoblastic Leukemia

Autor: Bruno Calabretta, Ilaria Iacobucci, Anna Ferrari, Giovanni Martinelli, Alessandro Rambaldi, Orietta Spinelli, Luke F. Peterson, Paolo Fortina, Sankar Addya, Samanta A. Mariani, Angela Rachele Soliera, Patrizia Porazzi, Marco De Dominici

Philadelphia chromosome–positive acute lymphoblastic leukemia (Ph+ ALL) is currently treated with BCR-ABL1 tyrosine kinase inhibitors (TKI) in combination with chemotherapy. However, most patients develop resistance to TKI through BCR-ABL1–depend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3115a43d1b4c5cb833c983a7d20077
https://doi.org/10.1158/0008-5472.c.6509714

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Supplementary Methods, Supplementary Figures 1-2, Supplementary Tables 1-4 from Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma

Autor: Sami N. Malek, Daniel J. Klionsky, Alfred E. Chang, Mark S. Kaminski, Shaomeng Wang, Mehmet Yildiz, Kamlai Saiya-Cork, Denzil Bernard, Luke F. Peterson, Meiyan Jin, Zhang Xiao Ying

Table S1. Yeast strains; Table S2. Primers used for yeasts mutagenesis; Table S3: B-factor for GTP/GDP during MD simulations with WT RRAGC or with point Mutations; Table S4: Energy contribution of each residue (kcal/mol) to GTP and GDP binding; Figur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44fe19f670e032adf0c68c9ab0a5776f
https://doi.org/10.1158/1078-0432.22462820

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Data from Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma

Autor: Sami N. Malek, Daniel J. Klionsky, Alfred E. Chang, Mark S. Kaminski, Shaomeng Wang, Mehmet Yildiz, Kamlai Saiya-Cork, Denzil Bernard, Luke F. Peterson, Meiyan Jin, Zhang Xiao Ying

Purpose: This study was performed to further our understanding of the biological and genetic basis of follicular lymphoma and to identify potential novel therapy targets.Experimental Design: We analyzed previously generated whole exome sequencing dat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ba15e2bb2ce65b3101efebf5a36bb6
https://doi.org/10.1158/1078-0432.c.6525221.v1

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Supplementary Figures S1-S11 from Targeting STAT5 or STAT5-Regulated Pathways Suppresses Leukemogenesis of Ph+ Acute Lymphoblastic Leukemia

Autor: Bruno Calabretta, Marja T. Nevalainen, Pierluigi Porcu, Luke F. Peterson, Alessandro Rambaldi, Orietta Spinelli, Samanta A. Mariani, Patrizia Porazzi, Marco De Dominici, Valentina Minieri

Supplementary Fig. S1. Effect of Doxycycline on shScramble (shSCR)-transduced Ph+ ALL cell lines. Supplementary Fig. S2. Effect of STAT5 inhibitor IST5-002 on Ph+ leukemia lines. Supplementary Fig. S3. Effect of treatment with IST5-002 in Ph like leu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1458862e00368a6abf088e68aad910
https://doi.org/10.1158/0008-5472.22420221

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