Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Luke Erber"'
Publikováno v:
PLoS Biology, Vol 20, Iss 8, p e3001757 (2022)
Proline hydroxylation (Hyp) regulates protein structure, stability, and protein-protein interaction. It is widely involved in diverse metabolic and physiological pathways in cells and diseases. To reveal functional features of the Hyp proteome, we in
Externí odkaz:
https://doaj.org/article/6193f4c0f4134f3d9556ff7a414fe49b
Autor:
Xiuye Wang, Thomas Hennig, Adam W. Whisnant, Florian Erhard, Bhupesh K. Prusty, Caroline C. Friedel, Elmira Forouzmand, William Hu, Luke Erber, Yue Chen, Rozanne M. Sandri-Goldin, Lars Dölken, Yongsheng Shi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Herpes simplex virus-1 (HSV-1) infection disrupts transcription termination (DoTT) of host genes, but underlying mechanisms are unclear. Here, Wang et al. show that the HSV-1 immediate early protein ICP27 induces DoTT through interaction with the mRN
Externí odkaz:
https://doaj.org/article/86795a19df404ef6a9b5cb941f4f5451
Publikováno v:
iScience, Vol 2, Iss , Pp 63-75 (2018)
Summary: Succinylation is a post-translational protein acylation modification that converts the cationic lysine side chain to an anion with large potential impacts on protein structure and function. Here we characterize the epigenome-wide distributio
Externí odkaz:
https://doaj.org/article/fc66aeb94f1740bead8cbe0a9f9ea618
Publikováno v:
Molecules, Vol 27, Iss 2, p 484 (2022)
Iron and oxygen deficiencies are common features in pathophysiological conditions, such as ischemia, neurological diseases, and cancer. Cellular adaptive responses to such deficiencies include repression of mitochondrial respiration, promotion of ang
Externí odkaz:
https://doaj.org/article/287aaed6b6e9428ea5b605a996556018
Publikováno v:
Toxics, Vol 9, Iss 10, p 247 (2021)
1,3-Butadiene (BD) is a common environmental and industrial chemical widely used in plastic and rubber manufacturing and also present in cigarette smoke and automobile exhaust. BD is classified as a known human carcinogen based on evidence of carcino
Externí odkaz:
https://doaj.org/article/59ee0b9d77924d828d0f4a8d27dcaa83
Autor:
Alexander K. Hurben, Luke Erber
Publikováno v:
Chem Res Toxicol
Artificial intelligence (AI) is a rapidly growing discipline in the field of chemical toxicology. Herein, we provide a broad overview of research presented at the Fall 2022 American Chemical Society meeting, highlighting how AI is being applied acros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df07a143649876fe61e3b4ef93dfe191
https://doi.org/10.1021/acs.chemrestox.2c00269
https://doi.org/10.1021/acs.chemrestox.2c00269
Autor:
Suresh S. Pujari, Mingxuan Wu, Jenna Thomforde, Zhipeng A. Wang, Christopher Chao, Noelle M. Olson, Luke Erber, William C. K. Pomerantz, Philip Cole, Natalia Y. Tretyakova
Publikováno v:
Angewandte Chemie. 133:26693-26698
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dbad7dc84ca5f12effd632b2964e69d
https://doi.org/10.1002/ange.202109418
https://doi.org/10.1002/ange.202109418
Autor:
Noelle M. Olson, Natalia Y. Tretyakova, Philip A. Cole, William C. K. Pomerantz, Jenna Thomforde, Mingxuan Wu, Suresh S. Pujari, Luke Erber, Zhipeng A. Wang, Christopher Chao
Publikováno v:
Angew Chem Int Ed Engl
DNA-protein cross-links (DPCs) between DNA epigenetic mark 5-formylC and lysine residues of histone proteins spontaneously form in human cells. Such conjugates are likely to influence chromatin structure and mediate DNA replication, transcription, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed293c975df237135f009ac9c8ab6f1
https://doi.org/10.1002/anie.202109418
https://doi.org/10.1002/anie.202109418
Publikováno v:
ACS Chem Biol
Selective death of midbrain dopaminergic neurons is a hallmark pathology of Parkinson’s disease (PD), but the molecular mechanisms that initiate the cascade of events resulting in neurodegeneration in PD remain unclear. Compelling evidence suggests
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e12188d39701a12b6c397ced966330
https://doi.org/10.1021/acschembio.1c00629
https://doi.org/10.1021/acschembio.1c00629
Autor:
Rashi Arora, Luke Erber, Natalia Y. Tretyakova, Freddys Rodriguez, Karin R. Vevang, Gunnar Boysen, Amanda Degner, Lisa A. Peterson, Scott J. Walmsley, Christopher Chao
Publikováno v:
Chemical Research in Toxicology. 34:119-131
Smoking is a leading cause of lung cancer, accounting for 81% of lung cancer cases. Tobacco smoke contains over 5000 compounds, of which more than 70 have been classified as human carcinogens. Of the many tobacco smoke constituents, 1,3-butadiene (BD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66dc447adc673961a5ff1644b9e7483e
https://doi.org/10.1021/acs.chemrestox.0c00376
https://doi.org/10.1021/acs.chemrestox.0c00376