Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Luke E Formosa"'
Autor:
Kyle Thompson, Nicole Mai, Monika Oláhová, Filippo Scialó, Luke E Formosa, David A Stroud, Madeleine Garrett, Nichola Z Lax, Fiona M Robertson, Cristina Jou, Andres Nascimento, Carlos Ortez, Cecilia Jimenez‐Mallebrera, Steven A Hardy, Langping He, Garry K Brown, Paula Marttinen, Robert McFarland, Alberto Sanz, Brendan J Battersby, Penelope E Bonnen, Michael T Ryan, Zofia MA Chrzanowska‐Lightowlers, Robert N Lightowlers, Robert W Taylor
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 11, Pp 1-13 (2018)
Abstract OXA1, the mitochondrial member of the YidC/Alb3/Oxa1 membrane protein insertase family, is required for the assembly of oxidative phosphorylation complexes IV and V in yeast. However, depletion of human OXA1 (OXA1L) was previously reported t
Externí odkaz:
https://doaj.org/article/0d713560574b49dfa1120e2d8edbb05c
Autor:
Yuqin Wu, Ashish Foollee, Andrea Y. Chan, Susanne Hille, Jana Hauke, Matthew P. Challis, Jared L. Johnson, Tomer M. Yaron, Victoria Mynard, Okka H. Aung, Maria Almira S. Cleofe, Cheng Huang, Terry C. C. Lim Kam Sian, Mohammad Rahbari, Suchira Gallage, Mathias Heikenwalder, Lewis C. Cantley, Ralf B. Schittenhelm, Luke E. Formosa, Greg C. Smith, Jürgen G. Okun, Oliver J. Müller, Patricia M. Rusu, Adam J. Rose
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The peptide hormone glucagon is a fundamental metabolic regulator that is also being considered as a pharmacotherapeutic option for obesity and type 2 diabetes. Despite this, we know very little regarding how glucagon exerts its pleiotropic
Externí odkaz:
https://doaj.org/article/2996febe0d924ecca6c4254d1c0d96ef
Autor:
Janet H C Yeo, Jarrod P J Skinner, Matthew J Bird, Luke E Formosa, Jian-Guo Zhang, Ruth M Kluck, Gabrielle T Belz, Mark M W Chong
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134326 (2015)
We identified Mrpl44 in a search for mammalian proteins that contain RNase III domains. This protein was previously found in association with the mitochondrial ribosome of bovine liver extracts. However, the precise Mrpl44 localization had been uncle
Externí odkaz:
https://doaj.org/article/17ead89c1e774d32bb315c1ab7f68bb6
Autor:
Rocio Rius, Neal K. Bennett, Kaustuv Bhattacharya, Lisa G. Riley, Zafer Yüksel, Luke E. Formosa, Alison G. Compton, Russell C. Dale, Mark J. Cowley, Velimir Gayevskiy, Saeed M. Al Tala, Abdulrahman A. Almehery, Michael T. Ryan, David R. Thorburn, Ken Nakamura, John Christodoulou
Publikováno v:
Human Mutation. 43:1970-1978
Primary mitochondrial diseases are a group of genetically and clinically heterogeneous disorders resulting from oxidative phosphorylation (OXPHOS) defects. COX11 encodes a copper chaperone that participates in the assembly of complex IV and has not b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e11260540fcdf4132eee665d92873d
https://doi.org/10.1002/humu.24453
https://doi.org/10.1002/humu.24453
Autor:
Jing Lu, Mohammad A. K. Azad, Julie L. M. Moreau, Yan Zhu, Xukai Jiang, Mary Tonta, Rachel Lam, Hasini Wickremasinghe, Jinxin Zhao, Jiping Wang, Harold A. Coleman, Luke E. Formosa, Tony Velkov, Helena C. Parkington, Alexander N. Combes, Joseph Rosenbluh, Jian Li
Publikováno v:
Cellular and Molecular Life Sciences. 79
Polymyxin antibiotics are often used as a last-line defense to treat life-threatening Gram-negative pathogens. However, polymyxin-induced kidney toxicity is a dose-limiting factor of paramount importance and can lead to suboptimal treatment. To eluci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b3fec64e02b396b48a4fb616157a13
https://doi.org/10.1007/s00018-022-04316-z
https://doi.org/10.1007/s00018-022-04316-z
Autor:
Thomas D. Jackson, Jordan J. Crameri, Linden Muellner-Wong, Ann E. Frazier, Catherine S. Palmer, Luke E. Formosa, Daniella H. Hock, Kenji M. Fujihara, Tegan Stait, Alice J. Sharpe, David R. Thorburn, Michael T. Ryan, David A. Stroud, Diana Stojanovski
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Significance Mitochondria are double-membraned eukaryotic organelles that house the proteins required for generation of ATP, the energy currency of cells. ATP generation within mitochondria is performed by five multisubunit complexes (complexes I to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fac105c4a578c043cfd9f0642cb50fa
https://doi.org/10.1073/pnas.2115566119
https://doi.org/10.1073/pnas.2115566119
Autor:
Yasushi Okazaki, Fumihito Nozaki, Kazuhiro R. Nitta, Masaru Shimura, Luke E. Formosa, Akira Ohtake, Yoshihito Kishita, Kei Murayama, Yukiko Yatsuka, Michael T. Ryan, Tatsuya Fujii
Publikováno v:
Clinical Genetics. 98:155-165
Mitochondrial complex I deficiency is caused by pathogenic variants in mitochondrial and nuclear genes associated with complex I structure and assembly. We report the case of a patient with NDUFA8-related mitochondrial disease. The patient presented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1efc3c844614d21936305f197e55cd9
https://doi.org/10.1111/cge.13773
https://doi.org/10.1111/cge.13773
Autor:
Baobei Lyu, Boris Reljic, Linden Muellner-Wong, David A. Stroud, Alice J. Sharpe, Dylan McGann, Michael T. Ryan, Marris G. Dibley, Felix Kraus, Luke E. Formosa
Publikováno v:
Mol Cell Proteomics
NDUFAB1 is the mitochondrial acyl carrier protein (ACP) essential for cell viability. Through its pantetheine-4′-phosphate post-translational modification, NDUFAB1 interacts with members of the leucine-tyrosine-arginine motif (LYRM) protein family.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cee3f5daec49c2a8a1ac66def469635
https://doi.org/10.1074/mcp.ra119.001784
https://doi.org/10.1074/mcp.ra119.001784
Autor:
Luke E. Formosa, Boris Reljic, Alice J. Sharpe, Megan J. Maher, Linden Muellner-Wong, David A. Stroud, Shadi Maghool, Michael T. Ryan
Cytochrome c oxidase assembly factor 7 (COA7) is a metazoan-specific assembly factor, critical for the biogenesis of mitochondrial complex IV (cytochrome c oxidase). Although mutations in COA7 have been linked in patients to complex IV assembly defec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9daa438fa48726ff811a742103c6ad3
https://doi.org/10.1101/2021.06.10.447992
https://doi.org/10.1101/2021.06.10.447992
Autor:
Michael T. Ryan, Alice J. Sharpe, Boris Reljic, Luke E. Formosa, Linden Muellner-Wong, David A. Stroud
Publikováno v:
Proc Natl Acad Sci U S A
Mitochondrial disease is a debilitating condition with a diverse genetic aetiology. Here, we report that TMEM126A, a protein that is mutated in patients with autosomal recessive optic atrophy, participates directly in the assembly of mitochondrial co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40b0bf50cc70d7cb9254cf340d08e20
https://pubmed.ncbi.nlm.nih.gov/33879611
https://pubmed.ncbi.nlm.nih.gov/33879611