DELTA2 guidance on choosing the target difference and undertaking and reporting the sample size calculation for a randomised controlled trial

Autor: Jonathan A. Cook, Steven A. Julious, William Sones, Lisa V. Hampson, Catherine Hewitt, Jesse A. Berlin, Deborah Ashby, Richard Emsley, Dean A. Fergusson, Stephen J. Walters, Edward C. F. Wilson, Graeme Maclennan, Nigel Stallard, Joanne C. Rothwell, Martin Bland, Louise Brown, Craig R. Ramsay, Andrew Cook, David Armstrong, Doug Altman, Luke D. Vale

Publikováno v: Trials, Vol 19, Iss 1, Pp 1-8 (2018)

Abstract Background A key step in the design of a RCT is the estimation of the number of participants needed in the study. The most common approach is to specify a target difference between the treatments for the primary outcome and then calculate th

Externí odkaz: https://doaj.org/article/93ca295eced54b009edc65547cf7cb8e

Practical help for specifying the target difference in sample size calculations for RCTs: the DELTA

Autor: Jonathan A, Cook, Steven A, Julious, William, Sones, Lisa V, Hampson, Catherine, Hewitt, Jesse A, Berlin, Deborah, Ashby, Richard, Emsley, Dean A, Fergusson, Stephen J, Walters, Edward Cf, Wilson, Graeme, MacLennan, Nigel, Stallard, Joanne C, Rothwell, Martin, Bland, Louise, Brown, Craig R, Ramsay, Andrew, Cook, David, Armstrong, Douglas, Altman, Luke D, Vale

Publikováno v: Health technology assessment (Winchester, England). 23(60)

BACKGROUND: The randomised controlled trial is widely considered to be the gold standard study for comparing the effectiveness of health interventions. Central to its design is a calculation of the number of participants needed (the sample size) for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca19a477529114c5400a159098296fa3
https://pubmed.ncbi.nlm.nih.gov/31661431

Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients

Autor: Peter J D, Andrews, Alison, Avenell, David W, Noble, Marion K, Campbell, Bernard L, Croal, William G, Simpson, Luke D, Vale, Claire G, Battison, David J, Jenkinson, Jonathan A, Cook, G, Hardy

Publikováno v: Andrews, P J D, Avenell, A, Noble, D W, Campbell, M K, Croal, B L, Simpson, W G, Vale, L D, Battison, C G, Jenkinson, D J & Cook, J A 2011, ' Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients ', British Medical Journal (BMJ), vol. 342, d1542, pp. 1-8 . https://doi.org/10.1136/bmj.d1542

OBJECTIVE: To determine whether inclusion of glutamine, selenium, or both in a standard isonitrogenous, isocaloric preparation of parenteral nutrition influenced new infections and mortality among critically ill patients. DESIGN: Randomised, double b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194b5fa8d0b59b74d3027b1aa40c102a
https://hdl.handle.net/20.500.11820/d8dda0d2-3dc3-4441-b286-bf5d225b3dc0

Methods for Specifying the Target Difference in a Randomised Controlled Trial: The Difference ELicitation in TriAls (DELTA) Systematic Review

Autor: Jenni Hislop, Temitope E Adewuyi, Luke D Vale, Kirsten Harrild, Cynthia Fraser, Tara Gurung, Douglas G Altman, Andrew H Briggs, Peter Fayers, Craig R Ramsay, John D Norrie, Ian M Harvey, Brian Buckley, Jonathan A Cook, DELTA group

Publikováno v: PLoS Medicine, Vol 11, Iss 5, p e1001645 (2014)
PLoS Medicine
5:e1001645

Jonathan Cook and colleagues systematically reviewed the literature for methods of determining the target difference for use in calculating the necessary sample size for clinical trials, and discuss which methods are best for various types of trials.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f6d406ded8c1324307c7c6b57dde912
https://doi.org/10.1371/journal.pmed.1001645

Assessing methods to specify the target difference for a randomised controlled trial: DELTA (Difference ELicitation in TriAls) review

Autor: Jonathan A Cook, Jennifer Hislop, Temitope E Adewuyi, Kirsten Harrild, Douglas G Altman, Craig R Ramsay, Cynthia Fraser, Brian Buckley, Peter Fayers, Ian Harvey, Andrew H Briggs, John D Norrie, Dean Fergusson, Ian Ford, Luke D Vale

Publikováno v: Health Technology Assessment, Vol 18, Iss 28 (2014)

Background: The randomised controlled trial (RCT) is widely considered to be the gold standard study for comparing the effectiveness of health interventions. Central to the design and validity of a RCT is a calculation of the number of participants n

Externí odkaz: https://doaj.org/article/b9d9e7adc101402b8c6c2a285b357d4a