Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Luke D. Humphreys"'
Autor:
Daniel F. A. R. Dourado, Balamurali Kannan, Darren Gray, Johann Chan, Michael J. Geier, Aliaksei Pukin, Stefan Mix, Mark E. Scott, Luke D. Humphreys, Xiaotian Wang, Gareth Brown
Publikováno v:
Organic Process Research & Development. 26:849-858
Autor:
Iain J. W. McKean, Luke D. Humphreys, Gideon Grogan, Amina Frese, Anibal Cuetos, Paul A. Hoskisson, Joanna C. Sadler, Glenn A. Burley
Publikováno v:
Angewandte Chemie. 131:17747-17752
A tandem enzymatic strategy to enhance the scope of C-alkylation of small molecules via the in situ formation of S-adenosyl methionine (SAM) cofactor analogues is described. A solvent-exposed channel present in the SAM-forming enzyme SalL tolerates 5
Publikováno v:
Synlett. 30:1776-1781
This report details the development of several suitable noncryogenic metalation conditions for the synthesis of oxazole zincate. Subsequent rounds of high-throughput catalyst screening ultimately led to the identification of several suitable Pd sourc
Publikováno v:
ChemBioChem. 18:992-995
A one-pot, two-step biocatalytic platform for the regiospecfic C-methylation and C-ethylation of aromatic substrates is described. The tandem process utilizes SalL (Salinospora tropica) for in situ synthesis of S-adenosyl-L-methionine (SAM), followed
Publikováno v:
Green Chemistry
Green Chemistry, 20(17), 3931-3943. The Royal Society of Chemistry
Green Chem
Green Chemistry, 20(17), 3931-3943. The Royal Society of Chemistry
Green Chem
Herein, we present a study on the oxidation of aldehydes to carboxylic acids using three recombinant aldehyde dehydrogenases (ALDHs). The ALDHs were used in purified form with a nicotinamide oxidase (NOx), which recycles the catalytic NAD(+) at the e
Publikováno v:
Chembiochem : a European journal of chemical biology. 18(11)
A one-pot, two-step biocatalytic platform for the regiospecfic C-methylation and C-ethylation of aromatic substrates is described. The tandem process utilises SalL (Salinospora tropica) for in situ synthesis of S-adenosyl-l-methionine (SAM), followed
C-methylation of aromatic small molecules by C-methyltransferases (C-MTs) is an important biological transformation that involves C–C bond formation using S-adenosyl-l-methionine (SAM) as the methyl donor. Here, two advances in the mechanistic unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba94973b67ba81827b1ef96127907233
https://strathprints.strath.ac.uk/60153/1/Sadler_etal_ACSCB_2017_C_methylation_of_coumarin_scaffolds_by_NovO.pdf
https://strathprints.strath.ac.uk/60153/1/Sadler_etal_ACSCB_2017_C_methylation_of_coumarin_scaffolds_by_NovO.pdf
Autor:
Suju Mathew, Matthew R. Hickey, Lynnette Oh, Luke D. Humphreys, Paul G. Richardson, David Hughes, Peter J. Dunn, Timothy D. White, John D. Hayler, Stijn Wuyts, Bernard Kaptein, Fabrice Gallou, Bill Hinkley, Apurba Bhattacharya, Kenneth J. Fraunhoffer, Rakeshwar Bandichhor, Louis J. Diorazio
Publikováno v:
Organic Process Research & Development. 18:863-874
Autor:
Marine Z. C. Hatit, Allan J. B. Watson, Ciaran P. Seath, Joanna C. Sadler, Benjamin C. Whitehurst, Luke D. Humphreys, Glenn A. Burley, Liam A. McLean, Robert J. Young
Publikováno v:
ChemInform. 47
Aromatic ynamines or N-alkynylheteroarenes are highly reactive alkyne components in Cu-catalyzed Huisgen [3 + 2] cycloaddition ("click") reactions. This enhanced reactivity enables the chemoselective formation of 1,4-triazoles using the representativ
Autor:
Luke D. Humphreys, John M. Gardiner, Adrian J. Jervis, Nigel S. Scrutton, Helen S. Toogood, A. Ni Cheallaigh, Eriko Takano, Shirley Tait
The era of synthetic biology heralds in a new, more “green” approach to fine chemical and pharmaceutical drug production. It takes the knowledge of natural metabolic pathways and builds new routes to chemicals, enables nonnatural chemical product
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16f711e5570267eab18f0bde8f81ba61
https://doi.org/10.1016/bs.mie.2016.02.020
https://doi.org/10.1016/bs.mie.2016.02.020