Výsledky vyhledávání - "Luke D. Heskett"

Insights into dimerization and four-helix bundle formation found by dissection of the dimer interface of the GrpE protein fromEscherichia coli

Autor: Sumesh S. Jain, Borries Demeler, Andrew F. Mehl, Luke D. Heskett

Publikováno v: Protein Science. 12:1205-1215

The GrpE heat shock protein from Escherichia coli has a homodimeric structure. The dimer interface encompasses two long alpha-helices at the NH(2)-terminal end from each monomer (forming a "tail"), which lead into a small four-helix bundle from which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944a0272f2559dffcaf4e794f93b35fb
https://doi.org/10.1110/ps.0300803

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A GrpE mutant containing the NH(2)-terminal 'tail' region is able to displace bound polypeptide substrate from DnaK

Autor: Kristina M. Neal, Luke D. Heskett, Andrew F. Mehl

Publikováno v: Biochemical and biophysical research communications. 282(2)

A key feature to the dimeric structure for the GrpE heat shock protein is the pair of long helices at the NH,-terminal end followed by a presumable extended segment of about 30 amino acids from each monomer. We have constructed a GrpE deletion mutant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5edc4213da956b416ee2429dc8fcabaa
https://pubmed.ncbi.nlm.nih.gov/11401497

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