Daisy-Chaining Photo- and Thermal Chemistry: Multistep Continuous Flow Synthesis of Visible-Light-Mediated Photochemistry with a High-Temperature Cascade Reaction

Autor: Luke D. Elliott, Alastair J. J. Lennox, Kevin I. Booker-Milburn

Publikováno v: Elliott, L D, Booker-Milburn, K I & Lennox, A J J 2021, ' Daisy-Chaining Photo-and Thermal Chemistry : Multi-Step Continuous Flow Synthesis of Visible-Light Mediated Photo-chemistry with a High Temperature Cascade Reaction ', Organic Process Research & Development, vol. 25, no. 8, pp. 1943-1949 . https://doi.org/10.1021/acs.oprd.1c00187

A highly efficient visible light mediated photochemical [2+2] cycloaddition is coupled with an atom economic thermal cascade reaction in a continuous flow process. By moving the photochemistry from UV to visible it is made more energy efficient and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d1854af8a70b571a011613162e9411
https://doi.org/10.1021/acs.oprd.1c00187

Integrated Multistep Photochemical and Thermal Continuous Flow Reactions: Production of Bicyclic Lactones with Kilogram Productivity

Autor: Ashley Love, Jonathan Hunter, Luke D. Elliott, Martyn Poliakoff, Kevin I. Booker Milburn, Charlotte A. Clark, Christopher Wiseall, Surajit Kayal, Xue-Zhong Sun, Darren S. Lee, Rowena A. Howie, Michael W. George, Magnus W. D. Hanson-Heine

Combining continuous photochemistry and flow reactions in high-temperature/high-pressure water has enabled us to integrate a multistep sequence into a single process with a reduction in reaction time to 24 h in batch. At the same time, applying this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2434af8aeae27b39b3f8d07d6355b683

Sequential Photochemical and Prins Reactions for the Diastereoselective Synthesis of Tricyclic Scaffolds

Autor: Bethan L. Donnelly, Luke D. Elliott, Kevin I. Booker-Milburn, Christine L. Willis

Publikováno v: Donnelly, B, Elliott, L, Willis, C & Booker-Milburn, K 2019, ' Sequential Photochemical and Prins Reactions for the Diastereoselective Synthesis of Tricyclic Scaffolds ', Angewandte Chemie-International Edition, vol. 58, no. 27, pp. 9095-9098 . https://doi.org/10.1002/anie.201903488

Cyclobutene alcohols undergo Prins cyclisations to generate single diastereomers of novel tricyclic heterocycles with five contiguous stereocentres. The reaction times are significantly shorter (ca. 15 min) than with traditional alkene substrates. St

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fefd893664d4d5ab6a3de6fb36a5597
https://doi.org/10.1002/ange.201903488

Escaping from Flatland: Antimalarial Activity of sp

Autor: Brian, Cox, James, Duffy, Victor, Zdorichenko, Corentin, Bellanger, Jessica, Hurcum, Benoît, Laleu, Kevin I, Booker-Milburn, Luke D, Elliott, Michael, Robertson-Ralph, Christopher J, Swain, Stephen J, Bishop, Irene, Hallyburton, Mark, Anderson

Publikováno v: ACS Med Chem Lett

[Image: see text] We utilized synthetic photochemistry to generate novel sp(3)-rich scaffolds and report the design, synthesis, and biological testing of a diverse series of amides based on the 1-(amino-methyl)-2-benzyl-2-aza-bicyclo[2.1.1]hexane sca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02ed168d905815de51346f3bba23bd26
https://pubmed.ncbi.nlm.nih.gov/33335673

Using batch reactor results to calculate optimal flow rates for the scale-up of UV photochemical reactions

Autor: David J. Klauber, Jonathan P. Knowles, Kevin I. Booker-Milburn, Luke D. Elliott, C. S. Stacey

Publikováno v: Elliott, L D, Knowles, J P, Stacey, C S, Klauber, D J & Booker-Milburn, K I 2018, ' Using batch reactor results to calculate optimal flow rates for the scale-up of UV photochemical reactions ', Reaction Chemistry and Engineering, vol. 3, no. 1, pp. 86-93 . https://doi.org/10.1039/c7re00193b, https://doi.org/10.1039/c7re00193b

The perceived difficulty of the scale-up of photochemistry is one of the main obstacles preventing its widespread use. Herein, we take three different challenging reactions and show that they can be reliably scaled, from immersion well batch reactors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1efea2f7fce403e08381dbc9a5ee260
https://doi.org/10.1039/c7re00193b