Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Luke C, Pilling"'
Autor:
Keenan A. Walker, Yang An, Abhay Moghekar, Ruin Moaddel, Michael R. Duggan, Zhongsheng Peng, Qu Tian, Luke C. Pilling, Shannon M. Drouin, Mark A. Espeland, Stephen R Rapp, Kathleen M Hayden, Aladdin H. Shadyab, Ramon Casanova, Madhav Thambisetty, Peter R. Rapp, Dimitrios Kapogiannis, Luigi Ferrucci, Susan M. Resnick
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-18 (2024)
Abstract Background Apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late onset Alzheimer’s disease (AD). This case-cohort study used targeted plasma biomarkers and large-scale proteomics to examine the biological mechani
Externí odkaz:
https://doaj.org/article/ee7fd18cf0994326a5954b2b904a2e34
Autor:
Francesco Casanova, Qu Tian, Daniel S. Williamson, Yong Qian, David Zweibaum, Jun Ding, Janice L. Atkins, David Melzer, Luigi Ferrucci, Luke C. Pilling
Publikováno v:
Neurobiology of Disease, Vol 197, Iss , Pp 106539- (2024)
Background: Iron overload is observed in neurodegenerative diseases, especially Alzheimer's disease (AD) and Parkinson's disease (PD). Homozygotes for the iron-overload (haemochromatosis) causing HFE p.C282Y variant have increased risk of dementia an
Externí odkaz:
https://doaj.org/article/0301ea7a15fa41d9878d92107d865ee1
Publikováno v:
BMJ Open, Vol 14, Iss 3 (2024)
Objectives HFE haemochromatosis genetic variants have an uncertain clinical penetrance, especially to older ages and in undiagnosed groups. We estimated p.C282Y and p.H63D variant cumulative incidence of multiple clinical outcomes in a large communit
Externí odkaz:
https://doaj.org/article/22d52cd1e74b4e34a09f5de25b2cdaa1
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4426 (2024)
The solute carrier organic anion transporter family member 1B1 (SLCO1B1) encodes the organic anion-transporting polypeptide 1B1 (OATP1B1 protein) that transports statins to liver cells. Common genetic variants in SLCO1B1, such as *5, cause altered sy
Externí odkaz:
https://doaj.org/article/84b2488bc8dc40d19247b4c7db34867e
Publikováno v:
JBMR Plus, Vol 7, Iss 10, Pp n/a-n/a (2023)
ABSTRACT The iron overload disorder hemochromatosis is primarily caused by the homozygous HFE p.C282Y variant, but the scale of excess related musculoskeletal morbidity is uncertain. We estimated hemochromatosis‐genotype associations with clinicall
Externí odkaz:
https://doaj.org/article/9067154c249c4aa3a9075c1607ba0727
Autor:
Chia-Ling Kuo, Rui Liu, Lucas da Cunha Godoy, Luke C. Pilling, Richard H. Fortinsky, Doug Brugge
Publikováno v:
Toxics, Vol 11, Iss 6, p 489 (2023)
Higher air pollution exposure and shorter leukocyte telomere length (LTL) are both associated with increased risk of coronary heart disease (CHD), and share plausible mechanisms, including inflammation. LTL may serve as a biomarker of air pollution e
Externí odkaz:
https://doaj.org/article/467326fd30eb446bbd4b46f69d4eba8d
Autor:
Chia-Ling Kuo, Ben Kirk, Meiruo Xiang, Luke C. Pilling, George A. Kuchel, Richard Kremer, Gustavo Duque
Publikováno v:
Nutrients, Vol 15, Iss 6, p 1474 (2023)
Background: Shorter leukocyte telomere length (LTL) is observed in multiple age-related diseases, which are also associated with vitamin D deficiency (i.e., osteosarcopenia, neurocognitive disorders, cancer, osteoarthritis, etc.), suggesting a close
Externí odkaz:
https://doaj.org/article/d4c62d983b754bb794db96c6e3fa53e3
Autor:
Garan Jones, Katerina Trajanoska, Adam J. Santanasto, Najada Stringa, Chia-Ling Kuo, Janice L. Atkins, Joshua R. Lewis, ThuyVy Duong, Shengjun Hong, Mary L. Biggs, Jian’an Luan, Chloe Sarnowski, Kathryn L. Lunetta, Toshiko Tanaka, Mary K. Wojczynski, Ryan Cvejkus, Maria Nethander, Sahar Ghasemi, Jingyun Yang, M. Carola Zillikens, Stefan Walter, Kamil Sicinski, Erika Kague, Cheryl L. Ackert-Bicknell, Dan E. Arking, B. Gwen Windham, Eric Boerwinkle, Megan L. Grove, Misa Graff, Dominik Spira, Ilja Demuth, Nathalie van der Velde, Lisette C. P. G. M. de Groot, Bruce M. Psaty, Michelle C. Odden, Alison E. Fohner, Claudia Langenberg, Nicholas J. Wareham, Stefania Bandinelli, Natasja M. van Schoor, Martijn Huisman, Qihua Tan, Joseph Zmuda, Dan Mellström, Magnus Karlsson, David A. Bennett, Aron S. Buchman, Philip L. De Jager, Andre G. Uitterlinden, Uwe Völker, Thomas Kocher, Alexander Teumer, Leocadio Rodriguéz-Mañas, Francisco J. García, José A. Carnicero, Pamela Herd, Lars Bertram, Claes Ohlsson, Joanne M. Murabito, David Melzer, George A. Kuchel, Luigi Ferrucci, David Karasik, Fernando Rivadeneira, Douglas P. Kiel, Luke C. Pilling
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Muscle weakness has been associated with morbidity and mortality in older people. Here, the authors have investigated this trait further by performing a genome-wide meta-analysis of grip strength and Mendelian randomization to discover causal relatio
Externí odkaz:
https://doaj.org/article/c432b68fa4c74f79a795551d0b9372a0
Publikováno v:
PLoS Genetics, Vol 17, Iss 9, p e1009783 (2021)
In this paper we review the methodological underpinnings of the general pharmacogenetic approach for uncovering genetically-driven treatment effect heterogeneity. This typically utilises only individuals who are treated and relies on fairly strong ba
Externí odkaz:
https://doaj.org/article/8edadb6867a74942bd7f7485670e41c3
Autor:
Rui Liu, Meiruo Xiang, Luke C. Pilling, David Melzer, Lihong Wang, Kevin J. Manning, David C. Steffens, Jack Bowden, Richard H. Fortinsky, George A. Kuchel, Taeho G. Rhee, Breno S. Diniz, Chia‐Ling Kuo
Publikováno v:
Aging Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::464b9cc1a0d68f4a866d77fa03fd0f82
https://doi.org/10.1111/acel.13808
https://doi.org/10.1111/acel.13808