Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Luke Becker"'
Effect of experimental hookworm infection on insulin resistance in people at risk of type 2 diabetes
Autor:
Doris R. Pierce, Malcolm McDonald, Lea Merone, Luke Becker, Fintan Thompson, Chris Lewis, Rachael Y. M. Ryan, Sze Fui Hii, Patsy A. Zendejas-Heredia, Rebecca J. Traub, Matthew A. Field, Tony Rahman, John Croese, Alex Loukas, Robyn McDermott, Paul R. Giacomin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract The reduced prevalence of insulin resistance and type 2 diabetes in countries with endemic parasitic worm infections suggests a protective role for worms against metabolic disorders, however clinical evidence has been non-existent. This 2-ye
Externí odkaz:
https://doaj.org/article/5b424d44f7ae4b2e899f402c57cbee3b
Autor:
Paul R. Chapman, Stacey Llewellyn, Helen Jennings, Luke Becker, Paul Giacomin, Rodney McDougall, Jennifer Robson, Alex Loukas, James McCarthy
Publikováno v:
Parasites & Vectors, Vol 15, Iss 1, Pp 1-7 (2022)
Abstract Background Although there is unprecedented interest in experimental human hookworm infection, details of hookworm manufacture and characterisation have been sparsely reported. In this report, we detail the production and characterisation of
Externí odkaz:
https://doaj.org/article/c69223f0b6ec4c078a1f258c3175e896
Autor:
Gebeyaw G Mekonnen, Bemnet A Tedla, Mark S Pearson, Luke Becker, Matt Field, Abena S Amoah, Govert van Dam, Paul L A M Corstjens, Takafira Mduluza, Francisca Mutapi, Alex Loukas, Javier Sotillo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 1, p e0010151 (2022)
Schistosoma haematobium is the leading cause of urogenital schistosomiasis and it is recognised as a class 1 carcinogen due to the robust association of infection with bladder cancer. In schistosomes, tetraspanins (TSPs) are abundantly present in dif
Externí odkaz:
https://doaj.org/article/83102718f43f43a0bc90839bc6fc9b30
Autor:
Mark S Pearson, PhD, Bemnet A Tedla, PhD, Gebeyaw G Mekonnen, PhD, Carla Proietti, PhD, Luke Becker, BSc, Rie Nakajima, MSc, Al Jasinskas, PhD, Denise L Doolan, PhD, Abena S Amoah, PhD, Stefanie Knopp, PhD, David Rollinson, PhD, Said M Ali, MSc, Fatma Kabole, MD, Cornelis H Hokke, PhD, Akim A Adegnika, MD, Matt A Field, PhD, Govert van Dam, PhD, Paul L A M Corstjens, PhD, Takafira Mduluza, PhD, Francisca Mutapi, PhD, Claude Oeuvray, PhD, Beatrice Greco, PhD, Sujittra Chaiyadet, PhD, Thewarach Laha, PhD, Pengfei Cai, PhD, Donald P McManus, PhD, Maria Elena Bottazzi, PhD, Philip L Felgner, PhD, Javier Sotillo, PhD, Alex Loukas, PhD
Publikováno v:
The Lancet Microbe, Vol 2, Iss 11, Pp e617-e626 (2021)
Summary: Background: Sensitive diagnostics are needed for effective management and surveillance of schistosomiasis so that current transmission interruption goals set by WHO can be achieved. We aimed to screen the Schistosoma haematobium secretome to
Externí odkaz:
https://doaj.org/article/e9c0510583ca4bf58360b82613221a36
Autor:
Mark S. Pearson, Bemnet A. Tedla, Luke Becker, Rie Nakajima, Al Jasinskas, Takafira Mduluza, Francisca Mutapi, Claude Oeuvray, Beatrice Greco, Javier Sotillo, Philip L. Felgner, Alex Loukas
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Despite the enormous morbidity attributed to schistosomiasis, there is still no vaccine to combat the disease for the hundreds of millions of infected people. The anthelmintic drug, praziquantel, is the mainstay treatment option, although its molecul
Externí odkaz:
https://doaj.org/article/58e793b9da6441c9a8a7d8fd0a89b538
Autor:
Benjamin F. R. Dickson, Jesse J. R. Masson, Helen J. Mayfield, Khin Saw Aye, Kyi May Htwe, Maureen Roineau, Athena Andreosso, Stephanie Ryan, Luke Becker, Janet Douglass, Patricia M. Graves
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 7, Iss 7, p 113 (2022)
The elimination of lymphatic filariasis (LF) is achieved through repeated mass drug administration (MDA) of anti-filarial medications, which interrupts transmission and prevents new infections. Accurate transmission assessments are critical to decidi
Externí odkaz:
https://doaj.org/article/121db0e096cf4ec8883601fb07b4d755
Autor:
Bemnet A Tedla, Javier Sotillo, Darren Pickering, Ramon M Eichenberger, Stephanie Ryan, Luke Becker, Alex Loukas, Mark S Pearson
Publikováno v:
PLoS Pathogens, Vol 15, Iss 12, p e1008213 (2019)
Cholinesterase (ChE) function in schistosomes is essential for orchestration of parasite neurotransmission but has been poorly defined with respect to the molecules responsible. Interrogation of the S. mansoni genome has revealed the presence of thre
Externí odkaz:
https://doaj.org/article/cf9fbff96c8344b6a5232396b5fba0cd
Autor:
Ahmed O. Shalash, Luke Becker, Jieru Yang, Paul Giacomin, Mark Pearson, Waleed M. Hussein, Alex Loukas, Mariusz Skwarczynski, Istvan Toth
Publikováno v:
Vaccines, Vol 9, Iss 9, p 1034 (2021)
Approximately 0.4 billion individuals worldwide are infected with hookworm. An effective vaccine is needed to not only improve the health of those affected and at high risk, but also to improve economic growth in disease-endemic areas. An ideal anti-
Externí odkaz:
https://doaj.org/article/6a6f34049d214de9a7621268816c1cbe
Autor:
Javier Sotillo, Mark S Pearson, Luke Becker, Gebeyaw G Mekonnen, Abena S Amoah, Govert van Dam, Paul L A M Corstjens, Janice Murray, Takafira Mduluza, Francisca Mutapi, Alex Loukas
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007362 (2019)
BackgroundSchistosomiasis is a neglected disease affecting hundreds of millions worldwide. Of the three main species affecting humans, Schistosoma haematobium is the most common, and is the leading cause of urogenital schistosomiasis. S. haematobium
Externí odkaz:
https://doaj.org/article/a19f474dc61e4ecb819f8f24a7aa8891
Autor:
Karma Yeshi, Darren J. Creek, Dovile Anderson, Edita Ritmejerytė, Luke Becker, Alex Loukas, Phurpa Wangchuk
Publikováno v:
Metabolites, Vol 10, Iss 11, p 446 (2020)
Soil-transmitted helminths, including hookworms and whipworms, infect billions of people worldwide. Their capacity to penetrate and migrate through their hosts’ tissues is influenced by the suite of molecules produced by the infective developmental
Externí odkaz:
https://doaj.org/article/1381f130b4df4490853136be0db5f871