Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Luke B Hesson"'
Obesity-induced sperm DNA methylation changes at satellite repeats are reprogrammed in rat offspring
Autor:
Neil A Youngson, Virginie Lecomte, Christopher A Maloney, Preston Leung, Jia Liu, Luke B Hesson, Fabio Luciani, Lutz Krause, Margaret J Morris
Publikováno v:
Asian Journal of Andrology, Vol 18, Iss 6, Pp 930-936 (2016)
There is now strong evidence that the paternal contribution to offspring phenotype at fertilisation is more than just DNA. However, the identity and mechanisms of this nongenetic inheritance are poorly understood. One of the more important questions
Externí odkaz:
https://doaj.org/article/0ed6e12b3ceb408b94b78873d07da818
Autor:
Luke B Hesson, Vibha Patil, Mathew A Sloane, Andrea C Nunez, Jia Liu, John E Pimanda, Robyn L Ward
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003636 (2013)
Hypomethylating agents reactivate tumor suppressor genes that are epigenetically silenced in cancer. Inevitably these genes are resilenced, leading to drug resistance. Using the MLH1 tumor suppressor gene as a model, we showed that decitabine-induced
Externí odkaz:
https://doaj.org/article/a7c73f1b66484fd68949921b4f7fc45a
Autor:
Sibel Saya, Patty Chondros, Anastasia Abela, Cathrine Mihalopolous, Mary Lou Chatterton, Jane Gunn, Timothy F. Chen, Thomas M. Polasek, Elise Dettmann, Rachel Brooks, Michelle King, Luke Spencer, Pavithran Alphonse, Shakira Milton, Georgia Ramsay, Zoe Siviour, Jamie Liew, Philip Ly, Matthew Thoenig, Raushaan Seychell, Floriana La Rocca, Luke B. Hesson, Nydia Mejias, Terri Sivertsen, Melanie Anne Galea, Chad Bousman, Jon Emery
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background The evidence for the clinical utility of pharmacogenomic (PGx) testing is growing, and guidelines exist for the use of PGx testing to inform prescribing of 13 antidepressants. Although previous randomised controlled trials of PGx
Externí odkaz:
https://doaj.org/article/55d8406932cd4f07b01ea962249ddd20
Autor:
Mirna Lechpammer, Austin Todd, Vivian Tang, Taryn Morningstar, Alexander Borowsky, Kiarash Shahlaie, John A. Kintner, John D. McPherson, John W. Bishop, Farzad Fereidouni, Zachary T. Harmany, Nicholas Coley, David Zagzag, Jason W. H. Wong, Jiang Tao, Luke B. Hesson, Leslie Burnett, Richard Levenson
Publikováno v:
Brain Sciences, Vol 14, Iss 1, p 108 (2024)
Whereas traditional histology and light microscopy require multiple steps of formalin fixation, paraffin embedding, and sectioning to generate images for pathologic diagnosis, Microscopy using Ultraviolet Surface Excitation (MUSE) operates through UV
Externí odkaz:
https://doaj.org/article/199e9290e30d41d68253f83c6c595d64
Autor:
Robyn L. Ward, Jason W.H. Wong, Michael J. Bourke, Nicholas J. Hawkins, Mathew A. Sloane, John E. Pimanda, Caroline E. Ford, Ashraf Dower, Regina Ryan, Dominik Beck, Andrea C. Nunez, Deborah Packham, Chau-To Kwok, Sameer Srivastava, Peter Zarzour, Benedict Ng, Luke B. Hesson
Supplementary Figure S1. LSTs profiled in this study. Supplementary Figure S2. Mutation validation by Sanger sequencing. Supplementary Figure S3. Analytical strategy for identifying LST driver genes and significantly altered pathways. Supplementary F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cf457a7e77c5ad70f774c7d2ceabd98
https://doi.org/10.1158/1541-7786.22511728
https://doi.org/10.1158/1541-7786.22511728
Autor:
Robyn L. Ward, Jason W.H. Wong, Michael J. Bourke, Nicholas J. Hawkins, Mathew A. Sloane, John E. Pimanda, Caroline E. Ford, Ashraf Dower, Regina Ryan, Dominik Beck, Andrea C. Nunez, Deborah Packham, Chau-To Kwok, Sameer Srivastava, Peter Zarzour, Benedict Ng, Luke B. Hesson
Laterally spreading tumors (LST) are colorectal adenomas that develop into extremely large lesions with predominantly slow progression to cancer, depending on lesion subtype. Comparing and contrasting the molecular profiles of LSTs and colorectal can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::221fb4456122357be3947d56b7638be5
https://doi.org/10.1158/1541-7786.c.6540025.v1
https://doi.org/10.1158/1541-7786.c.6540025.v1
Autor:
Robyn L. Ward, John E. Pimanda, Peter L. Molloy, Keith N. Rand, Nicholas J. Hawkins, Michael J. Bourke, Alan P. Meagher, Luke B. Hesson, Jia Liu
PDF file - 150K, Supplementary Table 1A: Effect of study group, age, sex, and smoking status on colonic global, LINE-1 and Alu DNA methylation, using linear and multiple linear regression. Supplementary Table 1B: Effect of study group, age, sex, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a09bda0af50c46e78bd6dd9768d24e8
https://doi.org/10.1158/1940-6207.22524012.v1
https://doi.org/10.1158/1940-6207.22524012.v1
Autor:
Robyn L. Ward, Jason W.H. Wong, Michael J. Bourke, Nicholas J. Hawkins, Mathew A. Sloane, John E. Pimanda, Caroline E. Ford, Ashraf Dower, Regina Ryan, Dominik Beck, Andrea C. Nunez, Deborah Packham, Chau-To Kwok, Sameer Srivastava, Peter Zarzour, Benedict Ng, Luke B. Hesson
Somatic mutations identified by WES.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0437a134b5b21ebc70c777ab21da6f3e
https://doi.org/10.1158/1541-7786.22511725.v1
https://doi.org/10.1158/1541-7786.22511725.v1
Autor:
Robyn L. Ward, John E. Pimanda, Peter L. Molloy, Keith N. Rand, Nicholas J. Hawkins, Michael J. Bourke, Alan P. Meagher, Luke B. Hesson, Jia Liu
PDF file - 107K, Supplemental Figure 1: Correlation between blood and colonic total folate concentration (r = 0.38; P = 0.002) in a subset (n=66) of Cancer Participants. Supplemental Figure 2: Correlation between blood and colonic formyl-H4folate dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d47f497c1772330fead7fff445d9af
https://doi.org/10.1158/1940-6207.22524018.v1
https://doi.org/10.1158/1940-6207.22524018.v1
Autor:
Lesley J. Ashton, Michelle Haber, Glenn M. Marshall, Murray D. Norris, Luke B. Hesson, Diana T. Lau
PDF file, 415K, Representative CoBRA and bisulfite sequencing results are shown in Supplementary Figure S1-S2. PCR conditions for CoBRA and bisulfite sequencing are listed in Supplementary Table S1 and S2. Clinical characteristics of the study popula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191f628ccb9a14a8e484603b4aa414c5
https://doi.org/10.1158/1078-0432.22446588.v1
https://doi.org/10.1158/1078-0432.22446588.v1