Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Luke B, Snell"'
Autor:
Adela Alcolea-Medina, Christopher Alder, Luke B. Snell, Themoula Charalampous, Alp Aydin, Gaia Nebbia, Tom Williams, Simon Goldenberg, Sam Douthwaite, Rahul Batra, Penelope R. Cliff, Hannah Mischo, Stuart Neil, Mark Wilks, Jonathan D. Edgeworth
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-13 (2024)
Abstract Background Clinical metagenomics involves the genomic sequencing of all microorganisms in clinical samples ideally after depletion of human DNA to increase sensitivity and reduce turnaround times. Current human DNA depletion methods preferen
Externí odkaz:
https://doaj.org/article/f1230e3b9d7043e3b1690633d8aee781
Autor:
Nneoma Okeke, Luke B. Snell, Balram Rathish, Amal Hussein, William Newsholme, Damien Mack, Aodhan Breathnach, Jonathan A. Otter
Publikováno v:
Infection Prevention in Practice, Vol 6, Iss 2, Pp 100325- (2024)
Summary: We investigated the dynamics of COVID-19 contacts subsequent conversion to SARS-CoV-2 infection in an inpatient setting across three National Health Service (NHS) Trusts. 9.2% (476/5,156) COVID-19 contacts met inclusion criteria, were typabl
Externí odkaz:
https://doaj.org/article/de71b8eda4ff4dec866fb67e577d669f
Autor:
Adela Alcolea-Medina, Christopher Alder, Luke B. Snell, Themoula Charalampous, Alp Aydin, Gaia Nebbia, Tom Williams, Simon Goldenberg, Sam Douthwaite, Rahul Batra, Penelope R. Cliff, Hannah Mischo, Stuart Neil, Mark Wilks, Jonathan D. Edgeworth
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/79a537bd9e8f4ad3b39631369efa7260
Autor:
Lara Payne, Adela Alcolea-Medina, Luke B Snell, Christopher Alder, Themoula Charalampous, Jake D Turnbull, Jonathan D Edgeworth, Rahul Batra, John L Klein, Anna L Goodman
Publikováno v:
Clinical Infection in Practice, Vol 21, Iss , Pp 100332- (2024)
Background: We describe a case of a 55-year-old shepherd with history of mycotic aneurysm presenting with a chronic aortic endovascular graft infection caused by Nocardia nova and a newly identified Variovorax sp which we named ‘Variovorax durovern
Externí odkaz:
https://doaj.org/article/6943fbd054e8406ca975d92cbf72017d
Autor:
Jeffrey Seow, Zayed A. Shalim, Carl Graham, Simon Kimuda, Aswin Pillai, Thomas Lechmere, Ashwini Kurshan, Atika M. Khimji, Luke B. Snell, Gaia Nebbia, Christine Mant, Anele Waters, Julie Fox, Michael H. Malim, Katie J. Doores
Publikováno v:
mBio, Vol 14, Iss 5 (2023)
ABSTRACT Despite the success of COVID-19 vaccines in preventing infection and/or severe disease, there has been an increase in SARS-CoV-2 infections in vaccinated individuals owing to the waning vaccine-derived immunity, and the emergence of new vari
Externí odkaz:
https://doaj.org/article/81c408cdde124becb570e71f189dd88d
Autor:
Wenjuan Wang, Luke B Snell, Davide Ferrari, Anna L Goodman, Nicholas M Price, Charles D Wolfe, Vasa Curcin, Jonathan D Edgeworth, Yanzhong Wang
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-7 (2022)
Abstract Introduction Randomised controlled trials have shown that steroids reduce the risk of dying in patients with severe Coronavirus disease 2019 (COVID-19), whilst many real-world studies have failed to replicate this result. We aim to investiga
Externí odkaz:
https://doaj.org/article/8dda7d566c344eda87fd1ba8ba4e2aa5
Autor:
Rory Munro, Nadine Holmes, Christopher Moore, Matthew Carlile, Alexander Payne, John R. Tyson, Thomas Williams, Christopher Alder, Luke B. Snell, Gaia Nebbia, Roberto Santos, Matt Loose
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
The ongoing SARS-CoV-2 pandemic demonstrates the utility of real-time sequence analysis in monitoring and surveillance of pathogens. However, cost-effective sequencing requires that samples be PCR amplified and multiplexed via barcoding onto a single
Externí odkaz:
https://doaj.org/article/ab2e85605bd24f9093a3d619cde1e42c
Autor:
Themoula Charalampous, Adela Alcolea-Medina, Luke B. Snell, Tom G. S. Williams, Rahul Batra, Christopher Alder, Andrea Telatin, Luigi Camporota, Christopher I. S. Meadows, Duncan Wyncoll, Nicholas A. Barrett, Carolyn J. Hemsley, Lisa Bryan, William Newsholme, Sara E. Boyd, Anna Green, Ula Mahadeva, Amita Patel, Penelope R. Cliff, Andrew J. Page, Justin O’Grady, Jonathan D. Edgeworth
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-16 (2021)
Abstract Background Clinical metagenomics (CMg) has the potential to be translated from a research tool into routine service to improve antimicrobial treatment and infection control decisions. The SARS-CoV-2 pandemic provides added impetus to realise
Externí odkaz:
https://doaj.org/article/3c7a335029394a13877c2e9c82267e9d
Autor:
Oliver Stirrup, James Blackstone, Fiona Mapp, Alyson MacNeil, Monica Panca, Alison Holmes, Nicholas Machin, Gee Yen Shin, Tabitha Mahungu, Kordo Saeed, Tranprit Saluja, Yusri Taha, Nikunj Mahida, Cassie Pope, Anu Chawla, Maria-Teresa Cutino-Moguel, Asif Tamuri, Rachel Williams, Alistair Darby, David L Robertson, Flavia Flaviani, Eleni Nastouli, Samuel Robson, Darren Smith, Matthew Loose, Kenneth Laing, Irene Monahan, Beatrix Kele, Sam Haldenby, Ryan George, Matthew Bashton, Adam A Witney, Matthew Byott, Francesc Coll, Michael Chapman, Sharon J Peacock, COG-UK HOCI Investigators, The COVID-19 Genomics UK (COG-UK) consortium, Joseph Hughes, Gaia Nebbia, David G Partridge, Matthew Parker, James Richard Price, Christine Peters, Sunando Roy, Luke B Snell, Thushan I de Silva, Emma Thomson, Paul Flowers, Andrew Copas, Judith Breuer
Publikováno v:
eLife, Vol 11 (2022)
Background: Viral sequencing of SARS-CoV-2 has been used for outbreak investigation, but there is limited evidence supporting routine use for infection prevention and control (IPC) within hospital settings. Methods: We conducted a prospective non-ran
Externí odkaz:
https://doaj.org/article/379a33f72af04755abd517e33357f2c4
Autor:
Thomas Lechmere, Luke B. Snell, Carl Graham, Jeffrey Seow, Zayed A. Shalim, Themoula Charalampous, Adela Alcolea-Medina, Rahul Batra, Gaia Nebbia, Jonathan D. Edgeworth, Michael H. Malim, Katie J. Doores
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Numerous studies have shown that a prior SARS-CoV-2 infection can greatly enhance the antibody response to COVID-19 vaccination, with this so called “hybrid immunity” leading to greater neutralization breadth against SARS-CoV-2 variants
Externí odkaz:
https://doaj.org/article/532af9eb26d2434498e1ed5b78f8f9bd