A bipartite boundary element restricts UBE3A imprinting to mature neurons

Autor: Noelle D. Germain, Justin Cotney, Christopher Stoddard, Stormy J. Chamberlain, Andrea Wilderman, Jack S. Hsiao, Geno J Villafano, Leighton J. Core, Luke A Wojenski

Publikováno v: Proceedings of the National Academy of Sciences. 116:2181-2186

Angelman syndrome (AS) is a severe neurodevelopmental disorder caused by the loss of function from the maternal allele of UBE3A , a gene encoding an E3 ubiquitin ligase. UBE3A is only expressed from the maternally inherited allele in mature human neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0711ad5925222d31c1c00317c427ef65
https://doi.org/10.1073/pnas.1815279116

Mitotic retention of H3K27 acetylation promotes rapid topological and transcriptional resetting of stem cell-related genes and enhancers upon G1 entry

Autor: Bobbie Pelham-Webb, Dafne Campigli Di Giammartino, Aristotelis Tsirigos, Luke A Wojenski, Andreas Kloetgen, Jiexi Li, Leighton J. Core, Alexander Polyzos, Effie Apostolou

The identity of dividing cells is challenged during mitosis, as transcription is halted and chromatin architecture drastically altered. How cell type-specific gene expression and genomic organization are faithfully reset upon G1 entry in daughter cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c8c26770534221c9e3246dbed9e6937
https://doi.org/10.1101/2020.06.02.130104

H3K27ac bookmarking promotes rapid post-mitotic activation of the pluripotent stem cell program without impacting 3D chromatin reorganization

Autor: Aristotelis Tsirigos, Dafne Campigli Di Giammartino, Bobbie Pelham-Webb, Alexander Polyzos, Andreas Kloetgen, Jiexi Li, Luke A Wojenski, Effie Apostolou, Leighton J. Core, Theodore Sakellaropoulos

Publikováno v: Mol Cell

During self-renewal, cell-type-defining features are drastically perturbed in mitosis and must be faithfully reestablished upon G1 entry, a process that remains largely elusive. Here, we characterized at a genome-wide scale the dynamic transcriptiona

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8936fb6fdd0bea08cd54aad74940d51f
https://doi.org/10.1016/j.molcel.2021.02.032

The RNA exosome contributes to gene expression regulation during stem cell differentiation

Autor: Torben Heick Jensen, Albin Sandelin, Leighton J. Core, Marta Lloret-Llinares, Yun Chen, Robin Andersson, Geno J Villafano, Luke A Wojenski, Evdoxia Karadoulama, Jette Bornholdt

Publikováno v: Llinares, M L, Karadoulama, E, Chen, Y, Wojenski, L A, Villafano, G J, Bornholdt, J, Andersson, R, Core, L, Sandelin, A & Jensen, T H 2018, ' The RNA exosome contributes to gene expression regulation during stem cell differentiation ', Nucleic Acids Research, vol. 46, no. 21, pp. 11502-11513 . https://doi.org/10.1093/nar/gky817
Lloret-Llinares, M, Karadoulama, E, Chen, Y, Wojenski, L A, Villafano, G J, Bornholdt, J, Andersson, R, Core, L, Sandelin, A & Jensen, T H 2018, ' The RNA exosome contributes to gene expression regulation during stem cell differentiation ', Nucleic Acids Research, vol. 46, no. 21, pp. 11502-11513 . https://doi.org/10.1093/nar/gky817
Nucleic Acids Research

Gene expression programs change during cellular transitions. It is well established that a network of transcription factors and chromatin modifiers regulate RNA levels during embryonic stem cell (ESC) differentiation, but the full impact of post-tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3294d77c17820113a897218e9231ed
https://curis.ku.dk/portal/da/publications/the-rna-exosome-contributes-to-gene-expression-regulation-during-stem-cell-differentiation(bf685cf5-0e7a-40c0-89c2-6306467237f7).html