Zobrazeno 1 - 10 of 47 pro vyhledávání: '"Luke A. Wittenburg"'
1
Akademický článek
Cardiac myosin inhibitor, CK-586, minimally reduces systolic function and ameliorates obstruction in feline hypertrophic cardiomyopathy
Autor: Victor N. Rivas, Amanda E. Crofton, Carina E. Jauregui, Jalena R. Wouters, Betty S. Yang, Luke A. Wittenburg, Joanna L. Kaplan, Darren T. Hwee, Anne N. Murphy, Bradley P. Morgan, Fady I. Malik, Samantha P. Harris, Joshua A. Stern
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Hypertrophic cardiomyopathy (HCM) remains the most common cardiomyopathy in humans and cats with few preclinical pharmacologic interventional studies. Small-molecule sarcomere inhibitors are promising novel therapeutics for the management of
Externí odkaz: https://doaj.org/article/1940ab1525324fb69489f617ae0a6c84
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2
Akademický článek
Effect of standard‐dose and high‐dose pimobendan on select indices of renal and cardiac function in dogs with American College of Veterinary Internal Medicine stage B2 myxomatous mitral valve disease
Autor: Joanna L. Kaplan, Lance C. Visser, Catherine T. Gunther‐Harrington, Eric S. Ontiveros, Luke A. Wittenburg, Carrie A. Palm, Joshua A. Stern
Publikováno v: Journal of Veterinary Internal Medicine, Vol 36, Iss 6, Pp 1892-1899 (2022)
Abstract Background Pimobendan might have favorable effects on renal function but this has not been well‐studied in dogs with myxomatous mitral valve disease (MMVD). Objectives Determine the effects of standard‐dose (SD_pimo) and high‐dose pimo
Externí odkaz: https://doaj.org/article/541c5d9eb41d4549b531325e7b087ef2
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3
Akademický článek
Pharmacokinetics of isavuconazole in healthy cats after oral and intravenous administration
Autor: Dennis J. Woerde, Luke A. Wittenburg, Jonathan D. Dear
Publikováno v: Journal of Veterinary Internal Medicine, Vol 36, Iss 4, Pp 1422-1429 (2022)
Abstract Background Isavuconazole is a triazole antifungal drug that has shown good efficacy in human patients. Absorption and pharmacokinetics have not been evaluated in cats. Objectives To determine the pharmacokinetics of isavuconazole in cats giv
Externí odkaz: https://doaj.org/article/71cf915efa094214a417dceb4d031a32
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4
Akademický článek
Vinblastine pharmacokinetics in mouse, dog, and human in the context of a physiologically based model incorporating tissue‐specific drug binding, transport, and metabolism
Autor: Sandra Witta, Keagan P. Collins, Dominique A. Ramirez, Joshua D. Mannheimer, Luke A. Wittenburg, Daniel L. Gustafson
Publikováno v: Pharmacology Research & Perspectives, Vol 11, Iss 1, Pp n/a-n/a (2023)
Abstract Vinblastine (VBL) is a vinca alkaloid‐class cytotoxic chemotherapeutic that causes microtubule disruption and is typically used to treat hematologic malignancies. VBL is characterized by a narrow therapeutic index, with key dose‐limiting
Externí odkaz: https://doaj.org/article/61d9b71b4f14428898236b51eb463339
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5
Akademický článek
Prevalence and Clinicopathologic Features of Canine Metastatic Melanoma Involving the Central Nervous System: A Retrospective Analysis and Comparative Review
Autor: Aryana M. Razmara, Luke A. Wittenburg, Sami Al-Nadaf, Ryan G. Toedebusch, Frederick J. Meyers, Christine M. Toedebusch
Publikováno v: Frontiers in Oncology, Vol 12 (2022)
BackgroundCentral nervous system (CNS) involvement is the leading cause of death in malignant melanoma. Rodent models, while vital to mechanistic investigation, have had limited success identifying effective therapies for melanoma brain metastases. T
Externí odkaz: https://doaj.org/article/4ef3df55891f4fc08a6d7ab2a272b02c
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7
Serum concentrations of gabapentin in cats with chronic kidney disease
Autor: Jessica M Quimby, Sarah K Lorbach, Ashlie Saffire, Amanda Kennedy, Luke A Wittenburg, Turi K Aarnes, Karina J Creighton, Sarah E Jones, Rene E Paschall, Emily M King, Clara E Bruner, Jessica N Wallinger, Karen A van Haaften
Publikováno v: Journal of Feline Medicine and Surgery. 24:1260-1266
Objectives The purpose of this study was to assess serum concentrations of gabapentin in cats with chronic kidney disease (CKD) vs clinically healthy cats. Methods Five healthy cats were enrolled in a pharmacokinetic study. A single 20 mg/kg dose of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a78bbe63380c3e4df4d043070470110
https://doi.org/10.1177/1098612x221077017
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8
Microglia-Derived Olfactomedin-like 3 Is a Potent Angiogenic Factor in Primary Mouse Brain Endothelial Cells: A Novel Target for Glioblastoma
Autor: Laila M. Joseph, Ryan G. Toedebusch, Eshetu Debebe, Aurelie H. Bastian, Christopher A. Lucchesi, Shafee Syed-Quadri, Luke A. Wittenburg, Xinbin Chen, Frederick J. Meyers, Christine M. Toedebusch
Publikováno v: International journal of molecular sciences, vol 23, iss 23
International Journal of Molecular Sciences; Volume 23; Issue 23; Pages: 14613
Neoangiogenesis, a hallmark feature of all malignancies, is robust in glioblastoma (GBM). Vascular endothelial growth factor (VEGF) has long been regarded as the primary pro-angiogenic molecule in GBM. However, anti-VEGF therapies have had little cli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fe13204aa7328281eed4520bfcf23e
https://pubmed.ncbi.nlm.nih.gov/36498941
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