Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Luke A. Simpson"'
Autor:
Luke A Simpson, Darren Crowley, Teri Forey, Helena Acosta, Zoltan Ferjentsik, Jodie Chatfield, Alexander Payne, Benjamin S Simpson, Catherine Redwood, James E Dixon, Nadine Holmes, Fei Sang, Ramiro Alberio, Matthew Loose, Andrew D Johnson
Publikováno v:
PLoS Biology, Vol 21, Iss 6, p e3002121 (2023)
Pluripotency defines the unlimited potential of individual cells of vertebrate embryos, from which all adult somatic cells and germ cells are derived. Understanding how the programming of pluripotency evolved has been obscured in part by a lack of da
Externí odkaz:
https://doaj.org/article/e160f857ecb94e4e8ba33d07731a5033
Autor:
Luke A. Simpson, Darren Crowley, Teri Forey, Helena Acosta, Zoltan Ferjentsik, Jodie Chatfield, Alexander Payne, Benjamin S. Simpson, Catherine Redwood, James E. Dixon, Nadine Holmes, Fei Sang, Ramiro Alberio, Mathew Loose, Andrew D. Johnson
Pluripotency defines the unlimited potential of cells in the primitive ectoderm of vertebrate embryos, from which all adult somatic cells and germ cells are derived. Understanding how the programing of pluripotency evolved has been obscured by the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d950ce93449c7ce95a3155ea4ec761
https://doi.org/10.1101/2022.09.08.507069
https://doi.org/10.1101/2022.09.08.507069
Autor:
Luke M. Simpson, Luke J. Fulcher, Gajanan Sathe, Abigail Brewer, Jin-Feng Zhao, Daniel R. Squair, Jennifer Crooks, Melanie Wightman, Nicola T. Wood, Robert Gourlay, Joby Varghese, Renata F. Soares, Gopal P. Sapkota
Publikováno v:
Cell Chemical Biology. 30:188-202.e6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a75b222f54b95f2562852ff79a37d0eb
https://doi.org/10.1016/j.chembiol.2023.01.003
https://doi.org/10.1016/j.chembiol.2023.01.003
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e57ab965ee5f139354570594cd08380a
https://doi.org/10.2139/ssrn.4006704
https://doi.org/10.2139/ssrn.4006704
Autor:
Luke M. Simpson, Lorraine Glennie, Abigail Brewer, Jin-Feng Zhao, Jennifer Crooks, Natalia Shpiro, Gopal P. Sapkota
Publikováno v:
Cell Chemical Biology. 29:1482-1504.e7
Proteolysis-targeting chimeras (PROTACs) bring a protein of interest (POI) into spatial proximity of an E3 ubiquitin ligase, promoting POI ubiquitylation and proteasomal degradation. PROTACs rely on endogenous cellular machinery to mediate POI degrad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10de3d13f4e56c735229de93674d721
https://doi.org/10.1016/j.chembiol.2022.08.004
https://doi.org/10.1016/j.chembiol.2022.08.004
Autor:
Sascha Röth, Ian G. Ganley, Luke M. Simpson, Alice Nardin, Thomas Macartney, Gopal P. Sapkota, Chiara Maniaci, Andrea Testa, Alessio Ciulli, Luke J. Fulcher
Publikováno v:
Cell Chemical Biology
Summary The affinity-directed protein missile (AdPROM) system utilizes specific polypeptide binders of intracellular proteins of interest (POIs) conjugated to an E3 ubiquitin ligase moiety to enable targeted proteolysis of the POI. However, a chemica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63004ba24d8e084145f65b190799f215
https://doi.org/10.1016/j.chembiol.2020.06.013
https://doi.org/10.1016/j.chembiol.2020.06.013