Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Luke A. Perera"'
Autor:
Luke A. Perera, Steffen Preissler, Nathan R. Zaccai, Sylvain Prévost, Juliette M. Devos, Michael Haertlein, David Ron
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The ER chaperone BiP is regulated by FICD-mediated AMPylation and deAMPylation. Here, the authors characterise the structure of mammalian AMPylated BiP bound to FICD, by X-ray crystallography and neutron scattering, providing insights into the mechan
Externí odkaz:
https://doaj.org/article/b1546d211ae74008933f9a4fd1200d65
Autor:
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 3, Pp 1-16 (2023)
Abstract Dysfunction of the endoplasmic reticulum (ER) in insulin‐producing beta cells results in cell loss and diabetes mellitus. Here we report on five individuals from three different consanguineous families with infancy‐onset diabetes mellitu
Externí odkaz:
https://doaj.org/article/39116a8baac7473c85e71501c8fe0c4e
Publikováno v:
eLife, Vol 9 (2020)
The metazoan endoplasmic reticulum (ER) serves both as a hub for maturation of secreted proteins and as an intracellular calcium storage compartment, facilitating calcium-release-dependent cellular processes. ER calcium depletion robustly activates t
Externí odkaz:
https://doaj.org/article/2df68a40864044a2966b41fdb69dcf50
Autor:
Luke A Perera, Andrew T Hattersley, Heather P Harding, Matthew N Wakeling, Sarah E Flanagan, Ibrahim Mohsina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco
Dysfunction of the endoplasmic reticulum (ER) in insulin‐producing beta cells results in cell loss and diabetes mellitus. Here we report on five individuals from three different consanguineous families with infancy‐onset diabetes mellitus and sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d816924c4de0973bffb20d6391665e67
https://www.repository.cam.ac.uk/handle/1810/345813
https://www.repository.cam.ac.uk/handle/1810/345813
Autor:
Luke A. Perera, Andrew T. Hattersley, Heather P. Harding, Matthew N. Wakeling, Sarah E. Flanagan, Ibrahim Moshina, Jamal Raza, Alice Gardham, David Ron, Elisa De Franco
Dysfunction of the endoplasmic reticulum (ER) in insulin-producing beta cells results in cell loss and diabetes mellitus. Here we report on 5 individuals from three different consanguineous families with infancy-onset diabetes mellitus and severe neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d323b1146ff705ff6bcba8a4e3890d0a
https://doi.org/10.1101/2022.05.14.22275020
https://doi.org/10.1101/2022.05.14.22275020
Autor:
David Ron, Luke A. Perera, Nathan R. Zaccai, Juliette M. Devos, Michael Haertlein, Steffen Preissler, Sylvain Prévost
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
'Nature Communications ', vol: 12, pages: 5004-1-5004-18 (2021)
Nature Communications
'Nature Communications ', vol: 12, pages: 5004-1-5004-18 (2021)
Nature Communications
The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a reversible inactivating post-translational modification. Both BiP AMPylation and deAMPylation are catalysed by a single ER-localised enzyme, FICD. Here we present crysta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fec1d51daa416bb43bfc7f35f77745
https://www.repository.cam.ac.uk/handle/1810/325252
https://www.repository.cam.ac.uk/handle/1810/325252
Autor:
David Ron, Juliette M. Devos, Nathan R. Zaccai, Luke A. Perera, Sylvain Prévost, Michael Haertlein, Steffen Preissler
The endoplasmic reticulum (ER) Hsp70 chaperone BiP is regulated by AMPylation, a reversible inactivating post-translational modification. Both BiP AMPylation and deAMPylation are catalysed by a single ER-localised enzyme, FICD. Here we present long-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4624a5c0dc58ea269d02d5d827050afa
https://doi.org/10.1101/2021.04.20.440599
https://doi.org/10.1101/2021.04.20.440599
Publikováno v:
Nature structural & molecular biology
The enzyme FICD was previously known to AMPylate the ER-resident chaperone BiP, inactivating the chaperone. Mammalian FICD is now shown to catalyze the removal of the AMP group from BiP. Protein folding homeostasis in the endoplasmic reticulum (ER) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08261cbd5b19f2b24b0973e2ac32bfbc
https://doi.org/10.1038/nsmb.3337
https://doi.org/10.1038/nsmb.3337
Autor:
Randy J. Read, Luke A. Perera, Yahui Yan, Claudia Rato, David Ron, Lisa Neidhardt, Stephen H. McLaughlin, Steffen Preissler
Publikováno v:
The EMBO Journal
AMPylation is an inactivating modification that alters the activity of the major endoplasmic reticulum (ER) chaperone BiP to match the burden of unfolded proteins. A single ER‐localised Fic protein, FICD (HYPE), catalyses both AMPylation and deAMPy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466986deec02fe8a92a607c5bdc4eaca