Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Luke A. Pallansch"'
Autor:
Andrew P. Halestrap, Philippe Gallay, Brigitte Rosenwirth, Kamel Besseghir, Marie-Pierre de Béthune, Dirk Jochmans, Roland Wenger, Michael Bobardt, Jean-Maurice Dumont, Luke A. Pallansch, Roger G. Ptak, Erik De Clercq, Urs T. Ruegg, Pietro Scalfaro, Johan Neyts
Publikováno v:
Antimicrobial Agents and Chemotherapy
The introduction of highly active antiretroviral therapy has led to significant changes in disease progression and mortality of human immunodeficiency virus (HIV) type 1 (HIV-1) infection and its sequela, AIDS. HIV-1 infection has been turned into a
Publikováno v:
Medicinal Chemistry. 3:513-519
A series of thioamides were designed as bio-isosteres to the non-nucleoside reverse transcriptase inhibitor trovirdine by replacement of the thiourea NH groups with methylene groups. Eight thioamides were synthesized and in vitro tested for inhibitor
Autor:
Rong Cao, Santosh Kumar, Scott R. Wilson, Chang-Zhi Dong, Luke A. Pallansch, Caroline R. Lefebure, Julie Russell, Jun Wang, Ying Li, Sameer P. Kawatkar, Ziwei Huang, Mi Youn Lim, Jing An, Dongxiang Liu, Won-Tak Choi, Yi-Gui Gao, Navid Madani, Joseph Sodroski
Publikováno v:
Journal of Virology. 81:11489-11498
Chemokines and their receptors play important roles in normal physiological functions and the pathogeneses of a wide range of human diseases, including the entry of human immunodeficiency virus type 1 (HIV-1). However, the use of natural chemokines t
Autor:
Luke A. Pallansch, Ena Bromley, Mary K. Howett, Brigitte E. Beer, Patricia A. Welsh, Robert W. Buckheit, Brian Wigdahl, Nicola Richardson-Harman, Bradley J. Catalone, Carol Lackman-Smith, Fred C. Krebs, Shendra R. Miller, Gustavo F. Doncel, Clay Osterling, Robin J. Shattock, Karen M. Watson, Jim A. Turpin, James E. Cummins, Charlene S. Dezzutti, Patricia Reichelderfer, Marie K. Mankowski, Patricia S. Fletcher
Publikováno v:
Antimicrobial Agents and Chemotherapy. 50:713-723
The first product to be clinically evaluated as a microbicide contained the nonionic surfactant nonoxynol-9 (nonylphenoxypolyethoxyethanol; N-9). Many laboratories have used N-9 as a control compound for microbicide assays. However, no published comp
Autor:
Christophe Marchand, Jie Liu, Yves Pommier, Yongli Guan, Erik De Clercq, Naijie Jing, Luke A. Pallansch, Carol Lackman-Smith
Publikováno v:
DNA and Cell Biology. 20:499-508
As novel anti-HIV agents, the G-tetrad-forming oligonucleotides have been explored for their structure-activity relations with regard to inhibition of integrase (IN) (N. Jing, Expert Opin. Investig. Drugs (2000) 9, 1777-1785). We have now developed t
Autor:
Diane E. Borst, E. Stodulkova, Luke A. Pallansch, Jing-Sheng Si, Nancy Remaley, John M. Nickerson, Jeffrey H Boatright
Publikováno v:
Current Eye Research. 23:20-32
To determine the sequences of the mouse and bovine interphotoreceptor retinoid-binding protein (IRBP) 5' flanking regions and whether these 5' flanking regions contain functional IRBP promoter activity in multiple cell types using both quantitative a
Autor:
Carol Lackman-Smith, Robert F. Rando, Michael E. Hogan, Sandy Lee, Erik De Clercq, Luke A. Pallansch, Naijie Jing
Publikováno v:
Journal of Biological Chemistry. 275:3421-3430
Recently, we have demonstrated that T30695, a G-tetrad-forming oligonucleotide, is a potent inhibitor of human immunodeficiency virus, type I (HIV-1) integrase and the K+-induced loop folding of T30695 plays a key role in the inhibition of HIV-1 inte
Publikováno v:
Antiviral Chemistry and Chemotherapy. 10:115-119
2'-Fluoro-2'3'-dideoxyarabinosyladenine (F-ddA), a nucleoside reverse transcriptase inhibitor of human immunodeficiency virus (HIV) replication, is currently being evaluated in clinical trials. Future monotherapy for the treatment of HIV is unlikely
Autor:
Luke A. Pallansch, Steven E. Fong, John D. Greenwood, Anita Mentzer, Lynn Rasmussen, Matthew A. Gonda, Terry D. Copeland, David Derse, Kunio Nagashima, Gregory J. Tobin, James Chadwick Williamson
Publikováno v:
Virology. 233:339-357
cDNAs encoding the bovine immunodeficiency virus (BIV) transactivator gene (tat) were cloned from virally infected cells and characterized. BIV expresses two distincttatmRNAs composed of three exons that are derived by alternative splicing. The BIV t
Autor:
Joseph L. Roberson, William Decker, Sherman F. Stinson, Melinda G. Hollingshead, John P. Bader, Luke A. Pallansch, Carrie Bonomi, Tim Siford, Robert Shores, Suzanne Borgel, Louis Malspeis, Robert W. Buckheit, Valerie Fliakas-Boltz, Cindy Elder
Publikováno v:
AIDS Research and Human Retroviruses. 13:789-796
A series of compounds related to oxathiin carboxanilide has been identified as nonnucleoside reverse transcriptase inhibitors (NNRTIs) of HIV-1, and structure-activity relationships have been described (Buckheit RW, et al.: Antimicrob Agents Chemothe