Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Luke A. O'Neill"'
Autor:
Naziia Kurmasheva, Aida Said, Boaz Wong, Priscilla Kinderman, Xiaoying Han, Anna H. F. Rahimic, Alena Kress, Madalina E. Carter-Timofte, Emilia Holm, Demi van der Horst, Christoph F. Kollmann, Zhenlong Liu, Chen Wang, Huy-Dung Hoang, Elina Kovalenko, Maria Chrysopoulou, Krishna Sundar Twayana, Rasmus N. Ottosen, Esben B. Svenningsen, Fabio Begnini, Anders E. Kiib, Florian E. H. Kromm, Hauke J. Weiss, Daniele Di Carlo, Michela Muscolini, Maureen Higgins, Mirte van der Heijden, Angelina Bardoul, Tong Tong, Attila Ozsvar, Wen-Hsien Hou, Vivien R. Schack, Christian K. Holm, Yunan Zheng, Melanie Ruzek, Joanna Kalucka, Laureano de la Vega, Walid A. M. Elgaher, Anders R. Korshoej, Rongtuan Lin, John Hiscott, Thomas B. Poulsen, Luke A. O’Neill, Dominic G. Roy, Markus M. Rinschen, Nadine van Montfoort, Jean-Simon Diallo, Henner F. Farin, Tommy Alain, David Olagnier
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-28 (2024)
Abstract The presence of heterogeneity in responses to oncolytic virotherapy poses a barrier to clinical effectiveness, as resistance to this treatment can occur through the inhibition of viral spread within the tumor, potentially leading to treatmen
Externí odkaz:
https://doaj.org/article/cf343351f5cf4766ad351ee93729ee99
Autor:
Silvia Galván-Peña, Richard G. Carroll, Carla Newman, Elizabeth C. Hinchy, Eva Palsson-McDermott, Elektra K. Robinson, Sergio Covarrubias, Alan Nadin, Andrew M. James, Moritz Haneklaus, Susan Carpenter, Vincent P. Kelly, Michael P. Murphy, Louise K. Modis, Luke A. O’Neill
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Host metabolic reprogramming plays a role in functional responses against pathogens. Here, the authors characterise malonylated proteins in macrophages and show that malonylation of the glycolytic enzyme GAPDH impacts cytokine production by modulatin
Externí odkaz:
https://doaj.org/article/4a15ae022f184e95bae97dad5d2e7a5a
Autor:
James Joseph Phelan, Kate McQuaid, Colin Kenny, Karl Michael Gogan, Dónal J. Cox, Sharee Ann Basdeo, Seónadh O’Leary, Simone Christa Tazoll, Cilian Ó Maoldomhnaigh, Mary P. O’Sullivan, Luke A. O’Neill, Maureen J. O’Sullivan, Joseph Keane
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Tuberculosis is the single biggest infectious killer in the world and presents a major global health challenge. Antimicrobial therapy requires many months of multiple drugs and incidences of drug resistant tuberculosis continues to rise. Consequently
Externí odkaz:
https://doaj.org/article/d064450510e04e1fadfdf5fe4ddbe2b6
Autor:
David Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, Nikolaj L. Villadsen, Christian Krapp, Anne L. Thielke, Anders Laustsen, Suraj Peri, Anne Louise Hansen, Lene Bonefeld, Jacob Thyrsted, Victor Bruun, Marie B. Iversen, Lin Lin, Virginia M. Artegoitia, Chenhe Su, Long Yang, Rongtuan Lin, Siddharth Balachandran, Yonglun Luo, Mette Nyegaard, Bernadette Marrero, Raphaela Goldbach-Mansky, Mona Motwani, Dylan G. Ryan, Katherine A. Fitzgerald, Luke A. O’Neill, Anne K. Hollensen, Christian K. Damgaard, Frank v. de Paoli, Hanne C. Bertram, Martin R. Jakobsen, Thomas B. Poulsen, Christian K. Holm
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Understanding how regulators of inflammation affect nucleic acid sensing is important for targeting research against inflammatory diseases and conditions. Here, the authors identify Nrf2 as an important negative regulator of STING and suggest a link
Externí odkaz:
https://doaj.org/article/5fc54bf6fbd8427c94401b47231854b6
Autor:
Jeroen Baardman, Sanne G.S. Verberk, Koen H.M. Prange, Michel van Weeghel, Saskia van der Velden, Dylan G. Ryan, Rob C.I. Wüst, Annette E. Neele, Dave Speijer, Simone W. Denis, Maarten E. Witte, Riekelt H. Houtkooper, Luke A. O’neill, Elena V. Knatko, Albena T. Dinkova-Kostova, Esther Lutgens, Menno P.J. de Winther, Jan Van den Bossche
Publikováno v:
Cell Reports, Vol 25, Iss 8, Pp 2044-2052.e5 (2018)
Summary: Metabolic reprogramming has emerged as a crucial regulator of immune cell activation, but how systemic metabolism influences immune cell metabolism and function remains to be investigated. To investigate the effect of dyslipidemia on immune
Externí odkaz:
https://doaj.org/article/d4969ea3a1584cdbbc7e5b1d85f55612
Autor:
Eva M. Palsson-McDermott, Lydia Dyck, Zbigniew Zasłona, Deepthi Menon, Anne F. McGettrick, Kingston H. G. Mills, Luke A. O’Neill
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Blocking interaction of the immune checkpoint receptor PD-1 with its ligand PD-L1 is associated with good clinical outcomes in a broad variety of malignancies. High levels of PD-L1 promote tumor growth by restraining CD8+ T-cell responses against tum
Externí odkaz:
https://doaj.org/article/edfc3777bf5f4598ab27f39b6f663cef
Autor:
Philipp M. Lepper, Martha Triantafilou, Luke A. O'Neill, Natalija Novak, Hermann Wagner, Andrew E. Parker, Kathy Triantafilou
Publikováno v:
Mediators of Inflammation, Vol 2010 (2010)
Externí odkaz:
https://doaj.org/article/be76b1be66c14f01b88474cad75f4be5
Autor:
Mimmi LE Lundahl, Morgane Mitermite, Dylan Gerard Ryan, Sarah Case, Niamh C Williams, Ming Yang, Roisin I Lynch, Eimear Lagan, Filipa M Lebre, Aoife L Gorman, Bojan Stojkovic, Adrian P Bracken, Christian Frezza, Frederick J Sheedy, Eoin M Scanlan, Luke AJ O'Neill, Stephen V Gordon, Ed C Lavelle
Publikováno v:
eLife, Vol 11 (2022)
Macrophages are a highly adaptive population of innate immune cells. Polarization with IFNγ and LPS into the ‘classically activated’ M1 macrophage enhances pro-inflammatory and microbicidal responses, important for eradicating bacteria such as M
Externí odkaz:
https://doaj.org/article/dfb7ec54071d42919b18133a72d40a8b
Autor:
Christian G. Peace, Luke A.J. O’Neill
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Macrophages exposed to inflammatory stimuli including LPS undergo metabolic reprogramming to facilitate macrophage effector function. This metabolic reprogramming supports phagocytic function, cytokine release, and ROS production that are critical to
Externí odkaz:
https://doaj.org/article/34973b0ee014417c946c5032c564705c
Autor:
Piyanat Wangsawatwong, Bernardo de Andrada Pereira, Jennifer N. Lehrman, Anna G.U. Sawa, Luke K. O’Neill, Jay D. Turner, Juan S. Uribe, Brian P. Kelly
Publikováno v:
Spine.