Daisy-Chaining Photo- and Thermal Chemistry: Multistep Continuous Flow Synthesis of Visible-Light-Mediated Photochemistry with a High-Temperature Cascade Reaction

Autor: Luke D. Elliott, Alastair J. J. Lennox, Kevin I. Booker-Milburn

Publikováno v: Elliott, L D, Booker-Milburn, K I & Lennox, A J J 2021, ' Daisy-Chaining Photo-and Thermal Chemistry : Multi-Step Continuous Flow Synthesis of Visible-Light Mediated Photo-chemistry with a High Temperature Cascade Reaction ', Organic Process Research & Development, vol. 25, no. 8, pp. 1943-1949 . https://doi.org/10.1021/acs.oprd.1c00187

A highly efficient visible light mediated photochemical [2+2] cycloaddition is coupled with an atom economic thermal cascade reaction in a continuous flow process. By moving the photochemistry from UV to visible it is made more energy efficient and c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d1854af8a70b571a011613162e9411
https://doi.org/10.1021/acs.oprd.1c00187

Flow photochemistry: Old light through new windows

Autor: Jonathan P. Knowles, Luke D. Elliott, Kevin I. Booker-Milburn

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 2025-2052 (2012)

Synthetic photochemistry carried out in classic batch reactors has, for over half a century, proved to be a powerful but under-utilised technique in general organic synthesis. Recent developments in flow photochemistry have the potential to allow thi

Externí odkaz: https://doaj.org/article/519fb41629654d36b0fbd77674e2f0dc

Escaping from Flatland: [2 + 2] Photocycloaddition; Conformationally Constrained sp3-rich Scaffolds for Lead Generation

Autor: Brian Cox, Luke D. Elliott, Kevin I. Booker-Milburn, Victor Zdorichenko, Michael Robertson-Ralph

Publikováno v: ACS Medicinal Chemistry Letters. 10:1512-1517

Pressure on researchers to deliver new medicines to the patient continues to grow. Attrition rates in the research and development process present a significant challenge to the viability of the current model of drug discovery. Analysis shows that in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d4ef66ce3f0965e8a9d7e04b2f3384b
https://doi.org/10.1021/acsmedchemlett.9b00409

Photochemically Produced Aminocyclobutanes as Masked Dienes in Thermal Electrocyclic Cascade Reactions

Autor: Luke D. Elliott, Kevin I. Booker-Milburn

Publikováno v: Elliott, L D & Booker-Milburn, K I 2019, ' Photochemically Produced Aminocyclobutanes as Masked Dienes in Thermal Electrocyclic Cascade Reactions ', Organic Letters, vol. 21, no. 5, pp. 1463-1466 . https://doi.org/10.1021/acs.orglett.9b00211

Cyclobutane products of a triplet sensitized enamide-alkene intramolecular [2 + 2] photocycloaddition have been shown to undergo fragmentation under acidic conditions. This lability has been exploited by inducing a complexity-generating thermal elect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c57dc45cce3fe9bf796d1b47864ecbb7
https://doi.org/10.1021/acs.orglett.9b00211

Rational Design of Triplet Sensitizers for the Transfer of Excited State Photochemistry from UV to Visible

Autor: Kevin I. Booker-Milburn, Surajit Kayal, Michael W. George, Luke D. Elliott

Publikováno v: Elliott, L D, Kayal, S, George, M W & Booker-Milburn, K I 2020, ' Rational Design of Triplet Sensitizers for the Transfer of Excited State Photochemistry from UV to Visible ', Journal of the American Chemical Society, vol. 142, no. 35, pp. 14947-14956 . https://doi.org/10.1021/jacs.0c05069

Time Dependent Density Functional Theory (TD-DFT) has been used to assist the design and synthesis of a series thioxan-thone triplet sensitizers. Calculated energies of the triplet excited state (ET) informed both the type and position of auxo-chrome

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4288c0533bbe5ca2b3f5818e8dca1772
https://hdl.handle.net/1983/57f49b35-2ebc-4a5b-be85-3fc0f853b29e