Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Luke A Wiley"'
Autor:
Ian C. Han, Laura R. Bohrer, Katherine N. Gibson-Corley, Luke A. Wiley, Arwin Shrestha, Brynnon E. Harman, Chunhua Jiao, Elliott H. Sohn, Rion Wendland, Brittany N. Allen, Kristan S. Worthington, Robert F. Mullins, Edwin M. Stone, Budd A. Tucker
Publikováno v:
Cell Transplantation, Vol 31 (2022)
Loss of photoreceptor cells is a primary feature of inherited retinal degenerative disorders including age-related macular degeneration and retinitis pigmentosa. To restore vision in affected patients, photoreceptor cell replacement will be required.
Externí odkaz:
https://doaj.org/article/8593038b4cab42488737abbcbbab0ab6
Autor:
Brittni A. Scruggs, Chunhua Jiao, Cathryn M. Cranston, Emily Kaalberg, Kai Wang, Stephen R. Russell, Luke A. Wiley, Robert F. Mullins, Edwin M. Stone, Budd A. Tucker, Elliott H. Sohn
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 8, Pp 797-809 (2019)
Abstract Subretinal delivery of stem cell‐derived retinal cells as a strategy to treat retinal degenerative blindness holds great promise. Currently, two clinical trials are underway in which human fetal retinal progenitor cells (RPCs) are being de
Externí odkaz:
https://doaj.org/article/e4373ca70dba4441939cd5b202824196
Autor:
Ian C. Han, Luke A. Wiley, Dalyz Ochoa, Mallory J. Lang, Brynnon E. Harman, Katie M. Sheehan, Robert F. Mullins, Edwin M. Stone, Budd A. Tucker
Publikováno v:
Gene Therapy. 30:362-368
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5af27e553641e317c4ab5a5ff53a7797
https://doi.org/10.1038/s41434-022-00365-y
https://doi.org/10.1038/s41434-022-00365-y
Autor:
Tasneem P. Sharma, Luke A. Wiley, S. Scott Whitmore, Kristin R. Anfinson, Cathryn M. Cranston, Douglas J. Oppedal, Heather T. Daggett, Robert F. Mullins, Budd A. Tucker, Edwin M. Stone
Publikováno v:
Stem Cell Research, Vol 21, Iss C, Pp 58-70 (2017)
Retinitis pigmentosa (RP) is a heterogeneous group of monogenic disorders characterized by progressive death of the light-sensing photoreceptor cells of the outer neural retina. We recently identified novel hypomorphic mutations in the tRNA Nucleotid
Externí odkaz:
https://doaj.org/article/836b80151f3646e89f9b759edb9bd48f
Autor:
Luke A. Wiley, Timothy M. Boyce, Emily E. Meyering, Dalyz Ochoa, Katie M. Sheehan, Edwin M. Stone, Robert F. Mullins, Budd A. Tucker, Ian C. Han
Publikováno v:
Human Gene Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bebba4595bceba3434faedb22543aa3a
https://doi.org/10.1089/hum.2022.222
https://doi.org/10.1089/hum.2022.222
Autor:
Andrew P Voigt, Nathaniel K Mullin, Kelly Mulfaul, Lola P Lozano, Luke A Wiley, Miles J Flamme-Wiese, Erin A Boese, Ian C Han, Todd E Scheetz, Edwin M Stone, Budd A Tucker, Robert F Mullins
Publikováno v:
Human Molecular Genetics. 31:2406-2423
The human choroid is a heterogeneous, highly vascular connective tissue that dysfunctions in age-related macular degeneration (AMD). In this study, we performed single-cell RNA sequencing on 21 human choroids, 11 of which were derived from donors wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cff17cffeccd72dfeee48431afefd9
https://doi.org/10.1093/hmg/ddac043
https://doi.org/10.1093/hmg/ddac043
Autor:
Robert F. Mullins, Budd A. Tucker, Emily E. Kaalberg, John H. Fingert, Erin R Burnight, Edwin M. Stone, Ian C. Han, Luke A Wiley, Timothy M. Boyce
Publikováno v:
J Ocul Pharmacol Ther
Purpose: Despite numerous recent advances in retinal gene therapy using adeno-associated viruses (AAVs) as delivery vectors, there remains a crucial need to identify viral vectors with the ability to transduce specific retinal cell types and that hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b6b59e7a8e794c3752a598654cec52
https://doi.org/10.1089/jop.2021.0057
https://doi.org/10.1089/jop.2021.0057
Autor:
Michael D. Wagoner, Laura R. Bohrer, Benjamin T. Aldrich, Mark A. Greiner, Robert F. Mullins, Kristan S. Worthington, Budd A. Tucker, Luke A. Wiley
Publikováno v:
Biology Open, Vol 7, Iss 5 (2018)
The purpose of this study was to devise a strategy for the derivation of corneal endothelial cells (CEnCs) from adult fibroblast-derived induced pluripotent stem cells (iPSCs). IPSCs were generated from an adult human with normal ocular history via e
Externí odkaz:
https://doaj.org/article/390cee8a22654e328b947693ac197a23
Autor:
Edwin M. Stone, Emilio F Tovar, Christy L Ralston, Budd A. Tucker, Elliott H. Sohn, Gabriella J Thomsen, Robert F. Mullins, Stephen R. Russell, Jessica L Fick, Erin R Burnight, Luke A Wiley, Justine L Cheng, Ian C. Han
Publikováno v:
Hum Gene Ther
Viral-mediated gene augmentation offers tremendous promise for the treatment of inherited retinal diseases. The development of effective gene therapy requires an understanding of the vector's tissue-specific behavior, which may vary depending on sero
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6c4bc8df248e4101987ff25921bd76
https://doi.org/10.1089/hum.2020.043
https://doi.org/10.1089/hum.2020.043
Publikováno v:
J Ocul Pharmacol Ther
Purpose: Widely used approaches for retinal disease modeling and in vitro therapeutic testing can be augmented by using tissue-engineered scaffolds with a precise 3-dimensional structure. However, the materials currently used for these scaffolds are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb616a0be3e80645bef1ba59022ba5b8
https://doi.org/10.1089/jop.2018.0146
https://doi.org/10.1089/jop.2018.0146