Endogenously produced itaconate negatively regulates innate-driven cytokine production and drives global ubiquitination in human macrophages

Autor: Luke A. Bourner, Linda A. Chung, Haiyan Long, Anne F. McGettrick, Junpeng Xiao, Kenneth Roth, Jade D. Bailey, Marie Strickland, Bo Tan, Jason Cunningham, Barry Lutzke, James McGee, Francella J. Otero, David C. Gemperline, Lin Zhang, Ying C. Wang, Michael J. Chalmers, Chiao-Wen Yang, Jesus A. Gutierrez, Luke A.J. O’Neill, Frank C. Dorsey

Publikováno v: Cell Reports, Vol 43, Iss 8, Pp 114570- (2024)

Summary: A wide variety of electrophilic derivatives of itaconate, the Kreb’s cycle-derived metabolite, are immunomodulatory, yet these derivatives have overlapping and sometimes contradictory activities. Therefore, we generated a genetic system to

Externí odkaz: https://doaj.org/article/55ca952d3ac049d4a45d8028c026aed2

A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.

Autor: Anthony Ryan, Mark Lynch, Sinead M Smith, Sylvie Amu, Hendrik J Nel, Claire E McCoy, Jennifer K Dowling, Eve Draper, Vincent O'Reilly, Ciara McCarthy, Julie O'Brien, Déirdre Ní Eidhin, Mary J O'Connell, Brian Keogh, Charles O Morton, Thomas R Rogers, Padraic G Fallon, Luke A O'Neill, Dermot Kelleher, Christine E Loscher

Publikováno v: PLoS Pathogens, Vol 7, Iss 6, p e1002076 (2011)

Clostridium difficile is the etiological agent of antibiotic-associated diarrhoea (AAD) and pseudomembranous colitis in humans. The role of the surface layer proteins (SLPs) in this disease has not yet been fully explored. The aim of this study was t

Externí odkaz: https://doaj.org/article/6486bcb3a30d4095ab5596eb0047788c

Contributors

Autor: Antonio Abbate, Ivona Aksentijevich, Marcelo Pires Amaral, Magaiver Andrade-Silva, Diego Angosto-Bazarra, Luca Antonioli, Kübra Aral, Juan I. Aróstegui, Jillian Barlow, Laura Benvenuti, Nunzia Bernardini, Massimo Bertinaria, Monika Biasizzo, Karina Ramalho Bortoluci, Dave Boucher, Laura Migliari Branco, David Brough, Petr Broz, Clare E. Bryant, Mark Cahill, Matthew Campbell, Soo Jung Cho, Shelbi Christgen, Rebecca C. Coll, Isabelle Couillin, Brianna Cyr, Sarah Dalmon, Juan Pablo de Rivero Vaccari, Francesco Di Virgilio, Andrea Dorfleutner, Sarah L. Doyle, Vanessa D'Antongiovanni, Ariel E. Feldstein, Matteo Fornai, Carlos García-Palenciano, Simone Gastaldi, Matthias Geyer, François Ghiringhelli, Anna Lisa Giuliani, José Manuel González-Navajas, Iva Hafner-Bratkovič, Shaima'a Hamarsheh, Michael T. Heneka, Thomas Henry, Jun-ichi Hikima, Inga V. Hochheiser, Alexander Hogg, Alexander Hooftman, Christopher Hoyle, Yin Huang, Sarah Huot-Marchand, Laura Hurtado-Navarro, Sushmita Jha, Thirumala-Devi Kanneganti, Benedikt Kaufmann, Andrea D. Kim, Nataša Kopitar-Jerala, Jordana Kron, Silvia Lucena Lage, Beatriz Lozano-Ruiz, Elisabetta Marini, Billie Matchett, Adolfo G. Mauro, Eleonora Mezzaroma, Michael R. Milward, Ingrid Kazue Mizuno Watanabe, Natsuki Morimoto, Sandip Mukherjee, Mar Orzáez, Luke A.J. O'Neill, Pablo Pelegrín, Carolina Pellegrini, Anaïs Perrichet, Joanna Picó, Nicola Potere, Alexander Pronko, Kishore Aravind Ravichandran, Nicolas Riteau, Kim S. Robinson, Cédric Rébé, Fadi N. Salloum, Mónica Sancho, Andrew Sandstrom, Niels Olsen Saraiva Câmara, Florian I. Schmidt, Liang Shan, Eoin Silke, Paula M. Soriano-Teruel, Christian Stehlik, Heather Stout-Delgado, Arianne L. Theiss, Jenny P.-Y. Ting, Stefano Toldo, Elviche L. Tsakem, Rebecca E. Tweedell, Amalia Tzoumpa, K. Venuprasad, Rose Wellens, Robert Zeiser, Franklin L. Zhong, Alessia Zotta

Publikováno v: Inflammasome Biology ISBN: 9780323918022

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1df40277879d3530be000cf63f0ec15f
https://doi.org/10.1016/b978-0-323-91802-2.01002-1

Adjacent-segment effects of lumbar cortical screw–rod fixation versus pedicle screw–rod fixation with and without interbody support

Autor: Piyanat Wangsawatwong, Bernardo de Andrada Pereira, Juan S. Uribe, Luke K O'Neill, Jay D. Turner, Brian P. Kelly, Anna G.U. Sawa, Jennifer N. Lehrman

Publikováno v: Journal of Neurosurgery: Spine. 35:263-269

OBJECTIVE Cortical screw–rod (CSR) fixation has emerged as an alternative to the traditional pedicle screw–rod (PSR) fixation for posterior lumbar fixation. Previous studies have concluded that CSR provides the same stability in cadaveric specime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eeb6f514d50ce321831b512badaa585
https://doi.org/10.3171/2020.11.spine20977

Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite

Autor: Anne F McGettrick, Luke AJ O’Neill

Publikováno v: Current opinion in immunology. 80

The metabolite itaconate (ITA) and its derivatives, both chemically synthesized and endogenous, have emerged as immunoregulators, with roles in limiting inflammation but also having effects on bacterial and viral infection. Some members of the ITA fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b40d59216523ca1b8d22898694a9b13
https://pubmed.ncbi.nlm.nih.gov/36446152