Zobrazeno 1 - 10
of 150
pro vyhledávání: '"Luke, Whitesell"'
Autor:
Jessie MacAlpine, Martin Daniel-Ivad, Daniela Atere, Bradley Laflamme, Nicole Robbins, William W. Navarre, Justin Nodwell, Luke Whitesell, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/6367050b2ccd49b4b0437df130a6aac3
Autor:
Jessie MacAlpine, Martin Daniel-Ivad, Zhongle Liu, Junko Yano, Nicole M. Revie, Robert T. Todd, Peter J. Stogios, Hiram Sanchez, Teresa R. O’Meara, Thomas A. Tompkins, Alexei Savchenko, Anna Selmecki, Amanda O. Veri, David R. Andes, Paul L. Fidel, Nicole Robbins, Justin Nodwell, Luke Whitesell, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/1edd977e074749009192e38dcc7e589d
Autor:
Sara Fallah, Dustin Duncan, Kyle D. Reichl, Michael J. Smith, Wenyu Wang, John A. Porco, Lauren E. Brown, Luke Whitesell, Nicole Robbins, Leah E. Cowen
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTCandida albicans, one of the most prevalent human fungal pathogens, causes diverse diseases extending from superficial infections to deadly systemic mycoses. Currently, only three major classes of antifungal drugs are available to treat syste
Externí odkaz:
https://doaj.org/article/0310e0d547f54976a2f68da74ed7b338
Autor:
Zhongle Liu, Pauline Basso, Saif Hossain, Sean D. Liston, Nicole Robbins, Luke Whitesell, Suzanne M. Noble, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Metabolic flexibility enables fungi to invade challenging host environments. In Candida albicans, a common cause of life-threatening infections in humans, an important contributor to flexibility is alternative oxidase (Aox) activity. Dramati
Externí odkaz:
https://doaj.org/article/77916211e1fb435cbbda60aadd78443d
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTCandida albicans is an opportunistic human fungal pathogen that causes common superficial mycoses in healthy populations and invasive disease in immunocompromised individuals. The fungus employs several virulence traits to cause disease in hu
Externí odkaz:
https://doaj.org/article/775f59568b4745328d9d481f8a0c880a
Autor:
Nicola T. Case, Johannes Westman, Michael T. Hallett, Jonathan Plumb, Aiman Farheen, Michelle E. Maxson, Jessie MacAlpine, Sean D. Liston, Bernhard Hube, Nicole Robbins, Luke Whitesell, Sergio Grinstein, Leah E. Cowen
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTFor the human fungal pathogen Candida albicans, metabolic flexibility and the ability to transition between yeast and filamentous growth states are key virulence traits that enable disease in the host. These traits are particularly important
Externí odkaz:
https://doaj.org/article/9701e5721a294187994ac9a51a0381cf
Autor:
Nicole M. Revie, Kali R. Iyer, Michelle E. Maxson, Jiabao Zhang, Su Yan, Caroline M. Fernandes, Kirsten J. Meyer, Xuefei Chen, Iwona Skulska, Meea Fogal, Hiram Sanchez, Saif Hossain, Sheena Li, Yoko Yashiroda, Hiroyuki Hirano, Minoru Yoshida, Hiroyuki Osada, Charles Boone, Rebecca S. Shapiro, David R. Andes, Gerard D. Wright, Justin R. Nodwell, Maurizio Del Poeta, Martin D. Burke, Luke Whitesell, Nicole Robbins, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
There is an urgent need for novel strategies to combat life-threatening fungal infections. Here, Revie et al. identify a compound that induces alterations in fungal membranes, synergizes with azole antifungals against the pathogen Candida albicans, a
Externí odkaz:
https://doaj.org/article/8bca44075efb4f07a12ae3b736c09d4d
Autor:
Sabine Ottilie, Madeline R. Luth, Erich Hellemann, Gregory M. Goldgof, Eddy Vigil, Prianka Kumar, Andrea L. Cheung, Miranda Song, Karla P. Godinez-Macias, Krypton Carolino, Jennifer Yang, Gisel Lopez, Matthew Abraham, Maureen Tarsio, Emmanuelle LeBlanc, Luke Whitesell, Jake Schenken, Felicia Gunawan, Reysha Patel, Joshua Smith, Melissa S. Love, Roy M. Williams, Case W. McNamara, William H. Gerwick, Trey Ideker, Yo Suzuki, Dyann F. Wirth, Amanda K. Lukens, Patricia M. Kane, Leah E. Cowen, Jacob D. Durrant, Elizabeth A. Winzeler
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Ottilie et al. employ an experimental evolution approach to investigate the role of transcription factors in yeast chemical resistance. Most emergent mutations in resistant strains were enriched in transcription factor coding genes, highlighting thei
Externí odkaz:
https://doaj.org/article/9094da31e4444ec8861d9e3850fe0c08
Autor:
Emily Puumala, Olga Zaslaver, Amy Chen, Dustin Duncan, Meea Fogal, Rebecca S. Shapiro, Mohammad T. Mazhab-Jafari, Luke Whitesell, J. Rafael Montenegro-Burke, Nicole Robbins, Leah E. Cowen
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Candida species are among the most prevalent causes of systemic fungal infection, posing a growing threat to public health. While Candida albicans is the most common etiological agent of systemic candidiasis, the frequency of infections caus
Externí odkaz:
https://doaj.org/article/1c5467aeaa4947168dabf4b8f207fb82
Autor:
Jessie MacAlpine, Martin Daniel-Ivad, Zhongle Liu, Junko Yano, Nicole M. Revie, Robert T. Todd, Peter J. Stogios, Hiram Sanchez, Teresa R. O’Meara, Thomas A. Tompkins, Alexei Savchenko, Anna Selmecki, Amanda O. Veri, David R. Andes, Paul L. Fidel, Nicole Robbins, Justin Nodwell, Luke Whitesell, Leah E. Cowen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Abstract The fungus Candida albicans is an opportunistic pathogen that can exploit imbalances in microbiome composition to invade its human host, causing pathologies ranging from vaginal candidiasis to fungal sepsis. Bacteria of the genus Lactobacill
Externí odkaz:
https://doaj.org/article/715093acde814215a41b6a51e866385d