Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Luke, Grundy"'
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2024)
Non-muscle invasive bladder cancer (NMIBC) accounts for ~70–75% of total bladder cancer tumors and requires effective early intervention to avert progression. The cornerstone of high-risk NMIBC treatment involves trans-urethral resection of the tum
Externí odkaz:
https://doaj.org/article/7eddcda82348451d8569f52cd9a38df1
Autor:
Cindy Tay, Luke Grundy
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic disorder characterized by pelvic and/or bladder pain, along with lower urinary tract symptoms that have a significant impact on an individual’s quality of life. The diverse range of
Externí odkaz:
https://doaj.org/article/b2a955c0713546dfbf23e177e09d6ae8
Autor:
Ashlee Caldwell, Luke Grundy, Andrea M. Harrington, Sonia Garcia-Caraballo, Joel Castro, Nigel W. Bunnett, Stuart M. Brierley
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract The mechanisms underlying chronic bladder conditions such as interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder syndrome (OAB) are incompletely understood. However, targeting specific receptors mediating neuronal sen
Externí odkaz:
https://doaj.org/article/e6c2108661e44edea86c27c271ba7cfa
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Overactive bladder (OAB) is a clinical syndrome defined by urinary urgency, increased daytime urinary frequency and/or nocturia, with or without urinary incontinence, that affects approximately 11% of the western population. OAB is accepted as an idi
Externí odkaz:
https://doaj.org/article/b1aa1b9492f34414b262f1b7e3fe9521
Autor:
Friederike Uhlig, Luke Grundy, Sonia Garcia-Caraballo, Stuart M. Brierley, Simon J. Foster, David Grundy
Publikováno v:
iScience, Vol 23, Iss 11, Pp 101695- (2020)
Summary: Despite recently established contributions of the intestinal microbiome to human health and disease, our understanding of bacteria-host communication pathways with regard to the gut-brain axis remains limited. Here we provide evidence that i
Externí odkaz:
https://doaj.org/article/deea55593b294d5d80a437c4a4caef38
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Endometriosis is a chronic and debilitating condition affecting ∼10% of women. Endometriosis is characterized by infertility and chronic pelvic pain, yet treatment options remain limited. In many respects this is related to an underlying lack of kn
Externí odkaz:
https://doaj.org/article/6e688b097531459d9687efd3215cbd10
Autor:
Luke Grundy, Ashlee Caldwell, Amanda Lumsden, Ehsan Mohammadi, Gerhard Hannig, Beverley Greenwood Van-Meervald, Stuart M. Brierley
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic urological condition characterised by urinary urgency, frequency and pelvic pain, that significantly impacts the quality of life for ∼5% of women. Bladder sensation is coordinated by
Externí odkaz:
https://doaj.org/article/3ed6b1d2b169425e9c16bf71885169d7
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Both TRPV1 and P2X receptors present on bladder sensory nerve fibres have been implicated in mechanosensation during bladder filling. The aim of this study was to determine possible interactions between these receptors in modulating afferent
Externí odkaz:
https://doaj.org/article/3e57c35388114772b91916e68ebcfb95
Autor:
Luke Grundy, Cindy Tay, Stewart Christie, Andrea M. Harrington, Joel Castro, Fernanda C. Cardoso, Richard J. Lewis, Vladimir Zagorodnyuk, Stuart M. Brierley
Publikováno v:
Pain. 164:1012-1026
The bladder wall is innervated by a complex network of afferent nerves that detect bladder stretch during filling. Sensory signals, generated in response to distension, are relayed to the spinal cord and brain to evoke physiological and painful sensa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e330f810d45b9ebbba23ee1cb4c5b2
https://doi.org/10.1097/j.pain.0000000000002795
https://doi.org/10.1097/j.pain.0000000000002795
Publikováno v:
Visceral Pain ISBN: 9783031257018
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3115045b2bbb028d2044e5e74820bc31
https://doi.org/10.1007/978-3-031-25702-5_18
https://doi.org/10.1007/978-3-031-25702-5_18
