Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Lukatsky, David B."'
Autor:
Mellul, Meir, Lahav, Shlomtzion, Imashimizu, Masahiko, Tokunaga, Yuji, Lukatsky, David B., Ram, Oren
Publikováno v:
In Biophysical Journal 16 August 2022 121(16):3126-3135
Autor:
Goldshtein, Matan, Lukatsky, David B.
The notion that transcription factors bind DNA only through specific, consensus binding sites has been recently questioned. In a pioneering study by Pugh and Venters no specific consensus motif for the positioning of the human pre-initiation complex
Externí odkaz:
http://arxiv.org/abs/1611.07776
Autor:
Goldshtein, Matan, Mellul, Meir, Deutch, Gai, Imashimizu, Masahiko, Takeuchi, Koh, Meshorer, Eran, Ram, Oren, Lukatsky, David B.
Publikováno v:
In Biophysical Journal 21 April 2020 118(8):2015-2026
Autor:
Afek, Ariel, Lukatsky, David B.
Publikováno v:
Biophysical Journal 104, 1107 (2013)
Genome-wide binding preferences of the key components of eukaryotic pre-initiation complex (PIC) have been recently measured with high resolution in Saccharomyces cerevisiae by Rhee and Pugh (Nature (2012) 483:295-301). Yet the rules determining the
Externí odkaz:
http://arxiv.org/abs/1303.1302
Autor:
Afek, Ariel, Lukatsky, David B.
Publikováno v:
Biophysical Journal 102(8), 1881-1888 (2012)
Recent genome-wide measurements of binding preferences of ~200 transcription regulators in the vicinity of transcription start sites in yeast, have provided a unique insight into the cis- regulatory code of a eukaryotic genome (Venters et al., Mol. C
Externí odkaz:
http://arxiv.org/abs/1204.4046
Publikováno v:
Biophysical Journal, Volume 101, Issue 10, 2465-2475 (2011)
Quantitative understanding of the principles regulating nucleosome occupancy on a genome-wide level is a central issue in eukaryotic genomics. Here, we address this question using budding yeast, Saccharomyces cerevisiae, as a model organism. We perfo
Externí odkaz:
http://arxiv.org/abs/1111.4779
Autor:
Sela, Itamar, Lukatsky, David B.
Publikováno v:
Biophys. J. 101(1), 160-166 (2011)
Transcription factors (TFs) are regulatory proteins that bind DNA in promoter regions of the genome and either promote or repress gene expression. Here we predict analytically that enhanced homo-oligonucleotide sequence correlations, such as poly(dA:
Externí odkaz:
http://arxiv.org/abs/1111.2998
Publikováno v:
Journal of Statistical Physics 146(4), 870-877 (2012)
Understanding design principles of biomolecular recognition is a key question of molecular biology. Yet the enormous complexity and diversity of biological molecules hamper the efforts to gain a predictive ability for the free energy of protein-prote
Externí odkaz:
http://arxiv.org/abs/1101.4529
Publikováno v:
Journal of Molecular Biology 409 (2011) pp. 439-449
Numerous experiments demonstrate a high level of promiscuity and structural disorder in organismal proteomes. Here we ask the question what makes a protein promiscuous, i.e., prone to non-specific interactions, and structurally disordered. We predict
Externí odkaz:
http://arxiv.org/abs/1011.0765
Publikováno v:
J. Chem. Phys. 135, 065104 (2011)
We predict analytically that diagonal correlations of amino acid positions within protein sequences statistically enhance protein propensity for nonspecific binding. We use the term 'promiscuity' to describe such nonspecific binding. Diagonal correla
Externí odkaz:
http://arxiv.org/abs/1004.5048