Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Lukasz Szyrwiel"'
Autor:
Vadim Demichev, Lukasz Szyrwiel, Fengchao Yu, Guo Ci Teo, George Rosenberger, Agathe Niewienda, Daniela Ludwig, Jens Decker, Stephanie Kaspar-Schoenefeld, Kathryn S. Lilley, Michael Mülleder, Alexey I. Nesvizhskii, Markus Ralser
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
The dia-PASEF technology uses ion mobility separation to reduce signal interferences and increase sensitivity of mass spectrometry-based proteomics. The authors present algorithms and a software solution, which boost proteomic depth in dia-PASEF expe
Externí odkaz:
https://doaj.org/article/530223c882bd4d63b31f0e4036920910
Autor:
Anita Balázs, Pamela Millar-Büchner, Michael Mülleder, Vadim Farztdinov, Lukasz Szyrwiel, Annalisa Addante, Aditi Kuppe, Tihomir Rubil, Marika Drescher, Kathrin Seidel, Sebastian Stricker, Roland Eils, Irina Lehmann, Birgit Sawitzki, Jobst Röhmel, Markus Ralser, Marcus A. Mall
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The nasal epithelium represents the first line of defense against inhaled pathogens, allergens, and irritants and plays a key role in the pathogenesis of a spectrum of acute and chronic airways diseases. Despite age-dependent clinical phenotypes trig
Externí odkaz:
https://doaj.org/article/fedeffcaad244444a146e43cd407fbae
Autor:
Vadim Demichev, Pinkus Tober-Lau, Tatiana Nazarenko, Oliver Lemke, Simran Kaur Aulakh, Harry J Whitwell, Annika Röhl, Anja Freiwald, Mirja Mittermaier, Lukasz Szyrwiel, Daniela Ludwig, Clara Correia-Melo, Lena J Lippert, Elisa T Helbig, Paula Stubbemann, Nadine Olk, Charlotte Thibeault, Nana-Maria Grüning, Oleg Blyuss, Spyros Vernardis, Matthew White, Christoph B Messner, Michael Joannidis, Thomas Sonnweber, Sebastian J Klein, Alex Pizzini, Yvonne Wohlfarter, Sabina Sahanic, Richard Hilbe, Benedikt Schaefer, Sonja Wagner, Felix Machleidt, Carmen Garcia, Christoph Ruwwe-Glösenkamp, Tilman Lingscheid, Laure Bosquillon de Jarcy, Miriam S Stegemann, Moritz Pfeiffer, Linda Jürgens, Sophy Denker, Daniel Zickler, Claudia Spies, Andreas Edel, Nils B Müller, Philipp Enghard, Aleksej Zelezniak, Rosa Bellmann-Weiler, Günter Weiss, Archie Campbell, Caroline Hayward, David J Porteous, Riccardo E Marioni, Alexander Uhrig, Heinz Zoller, Judith Löffler-Ragg, Markus A Keller, Ivan Tancevski, John F Timms, Alexey Zaikin, Stefan Hippenstiel, Michael Ramharter, Holger Müller-Redetzky, Martin Witzenrath, Norbert Suttorp, Kathryn Lilley, Michael Mülleder, Leif Erik Sander, PA-COVID-19 Study group, Florian Kurth, Markus Ralser
Publikováno v:
PLOS Digital Health, Vol 1, Iss 1, p e0000007 (2022)
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores show only limited per
Externí odkaz:
https://doaj.org/article/8c7d05377e464ce084389ab5400bb7df
Autor:
Gabriel Piedrafita, Sreejith J Varma, Cecilia Castro, Christoph B Messner, Lukasz Szyrwiel, Julian L Griffin, Markus Ralser
Publikováno v:
PLoS Biology, Vol 19, Iss 12, p e3001468 (2021)
The structure of the metabolic network is highly conserved, but we know little about its evolutionary origins. Key for explaining the early evolution of metabolism is solving a chicken-egg dilemma, which describes that enzymes are made from the very
Externí odkaz:
https://doaj.org/article/21656b2790fa4e38b64a797d017961a5
Autor:
Deepti Talwar, Colin G. Miller, Justus Grossmann, Lukasz Szyrwiel, Torsten Schwecke, Vadim Demichev, Ana-Matea Mikecin Drazic, Anand Mayakonda, Pavlo Lutsik, Carmen Veith, Michael D. Milsom, Karin Müller-Decker, Michael Mülleder, Markus Ralser, Tobias P. Dick
Publikováno v:
Nature Metabolism. 5:660-676
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is known to contain an active-site cysteine residue undergoing oxidation in response to hydrogen peroxide, leading to rapid inactivation of the enzyme. Here we show that human and mouse cells expressin
Autor:
Christoph B. Messner, Vadim Demichev, Julia Muenzner, Simran K. Aulakh, Natalie Barthel, Annika Röhl, Lucía Herrera-Domínguez, Anna-Sophia Egger, Stephan Kamrad, Jing Hou, Guihong Tan, Oliver Lemke, Enrica Calvani, Lukasz Szyrwiel, Michael Mülleder, Kathryn S. Lilley, Charles Boone, Georg Kustatscher, Markus Ralser
Publikováno v:
Cell
Messner, C B, Demichev, V, Muenzner, J, Aulakh, S K, Barthel, N, Röhl, A, Herrera-Domínguez, L, Egger, A, Kamrad, S, Hou, J, Tan, G, Lemke, O, Calvani, E, Szyrwiel, L, Mülleder, M, Lilley, K S, Boone, C, Kustatscher, G & Ralser, M 2023, ' The proteomic landscape of genome-wide genetic perturbations ', Cell, vol. 186, no. 9 . https://doi.org/10.1016/j.cell.2023.03.026
Messner, C B, Demichev, V, Muenzner, J, Aulakh, S K, Barthel, N, Röhl, A, Herrera-Domínguez, L, Egger, A, Kamrad, S, Hou, J, Tan, G, Lemke, O, Calvani, E, Szyrwiel, L, Mülleder, M, Lilley, K S, Boone, C, Kustatscher, G & Ralser, M 2023, ' The proteomic landscape of genome-wide genetic perturbations ', Cell, vol. 186, no. 9 . https://doi.org/10.1016/j.cell.2023.03.026
Functional genomic strategies have become fundamental for annotating gene function and regulatory networks. Here, we combined functional genomics with proteomics by quantifying protein abundances in a genome-scale knockout library in Saccharomyces ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2d60b8045d42b55731221ebbf452f9
https://hdl.handle.net/21.11116/0000-000D-2B00-321.11116/0000-000D-2B02-1
https://hdl.handle.net/21.11116/0000-000D-2B00-321.11116/0000-000D-2B02-1
Increased throughput in proteomic experiments can improve accessibility of proteomic platforms, reduce costs and facilitate new approaches in systems biology and biomedical research. Here we propose Speedy-PASEF, a combination of analytical flow rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11889c68bff93a4326297dbb0e378459
https://doi.org/10.1101/2023.02.17.528968
https://doi.org/10.1101/2023.02.17.528968
Autor:
Stephan Kamrad, Clara Correia-Melo, Lukasz Szyrwiel, Simran Kaur Aulakh, Jürg Bähler, Vadim Demichev, Michael Mülleder, Markus Ralser
Publikováno v:
Nature Microbiology
Genetically identical cells are known to differ in many physiological parameters such as growth rate and drug tolerance. Metabolic specialization is believed to be a cause of such phenotypic heterogeneity, but detection of metabolically divergent sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987c07735c7e604ed1f6b7dc67bd8583
We present Slice-PASEF, a novel mass spectrometry technology based on trapped ion mobility separation of ions. Slice-PASEF allows to achieve the theoretical maximum of MS/MS sensitivity and boosts proteomics of low sample amounts. Leveraging Slice-PA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fefc08c9fd9541282441c1b8a77b9299
https://doi.org/10.1101/2022.10.31.514544
https://doi.org/10.1101/2022.10.31.514544
Autor:
Clara Correia-Melo, Stephan Kamrad, Christoph B. Messner, Roland Tengölics, Lucía Herrera-Dominguez, St John Townsend, Mohammad Tauqeer Alam, Anja Freiwald, Kate Campbell, Simran Aulakh, Lukasz Szyrwiel, Jason S. L. Yu, Aleksej Zelezniak, Vadim Demichev, Michael Muelleder, Balázs Papp, Markus Ralser
Metabolism is fundamentally intertwined with the ageing process. We here report that a key determinant of cellular lifespan is not only nutrient supply and intracellular metabolism, but also metabolite exchange interactions that occur between cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c03e7be56704f3cfd9050d19dc485d40
https://doi.org/10.1101/2022.03.07.483228
https://doi.org/10.1101/2022.03.07.483228