Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lukasz Szoka"'
Publikováno v:
Molecules, Vol 29, Iss 17, p 4091 (2024)
Despite unquestionable advances in therapy, melanoma is still characterized by a high mortality rate. For years, high expectations have been raised by compounds of natural origin as a component of pharmacotherapy, particularly by triterpenes found in
Externí odkaz:
https://doaj.org/article/20bf4b45718d460182427b4adc70a4a3
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Cancer of the corpus uteri and cervix uteri, collectively ranks second among new cancer cases in women after breast cancer. Therefore, investigation of new anticancer agents and identifying new molecular targets presents a challenge to improve effect
Externí odkaz:
https://doaj.org/article/a3b9295abcb244af80a46966e29538b4
Autor:
Thi Yen Ly Huynh, Ilona Oscilowska, Lukasz Szoka, Ewelina Piktel, Weronika Baszanowska, Katarzyna Bielawska, Robert Bucki, Wojciech Miltyk, Jerzy Palka
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Although the antineoplastic activity of metformin (MET) is well established, the underlying mechanism of the activity is not understood. Since MET activates AMP kinase (AMPK) and proline dehydrogenase/proline oxidase (PRODH/POX) is stimulated by AMPK
Externí odkaz:
https://doaj.org/article/a7309ecbd66c440ea52e6efff7a95d36
Autor:
Valery A. Isidorov, Jolanta Maslowiecka, Lukasz Szoka, Naldo Pellizzer, Dora Miranda, Ewa Olchowik-Grabarek, Monika Zambrzycka, Izabela Swiecicka
Publikováno v:
Molecules, Vol 27, Iss 22, p 7686 (2022)
The chemical composition of propolis of four species of stingless bees (SLBs) from Argentina was determined, and its antibacterial and anticancer activity was evaluated on selected types of microbes and cancer cell lines. Volatile secretions of all p
Externí odkaz:
https://doaj.org/article/0237dc7b05f74886839ab15028476fb9
Autor:
Lukasz Szoka, Jerzy Palka
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 132, Iss , Pp 110741- (2020)
Capsaicin (N-vanillyl-8-methyl-alpha-nonenamide), a spicy, neurotoxic component of hot pepper is a ligand of vanilloid type-I (TRPV1) receptor of anti-cancer potential. However, molecular mechanism of its action is not fully understood. We found that
Externí odkaz:
https://doaj.org/article/ed5c90dbcc8d4b03aa2b48757d17dfe8
Publikováno v:
Molecules, Vol 29, Iss 19, p 4658 (2024)
Carpesium macrocephalum, a species native to China, Korea, Japan, and Russia, has been used medicinally in the countries of its origin. Though mono- and sesquiterpenoids are known constituents of C. macrocephalum, the complete analysis of essential o
Externí odkaz:
https://doaj.org/article/f12df664ded640bd826672d53fe53c64
Autor:
Kornelia Hlebowicz-Sarat, Jacek Karaszewski, Jerzy Pałka, Ewa Karna, Stanisław Boryczka, Lukasz Szoka
Publikováno v:
Biomedicine & Pharmacotherapy. 95:429-436
Since betulin (Bet) and its acetylenic derivative, 28-O-propynoylbetulin (proBet) were shown to induce apoptosis in several cancer cell lines, we studied the mechanism of this process in human endometrial adenocarcinoma cells (EA). Previous studies s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef702dcc8ca2e6059096bd52e8263825
https://doi.org/10.1016/j.biopha.2017.08.104
https://doi.org/10.1016/j.biopha.2017.08.104
Publikováno v:
Molecular and Cellular Biochemistry
Abundance of proline (Pro) in collagen molecule led us to investigate whether Pro supply affects collagen biosynthesis in human skin fibroblasts. Treatment of the cells with milimolar concentrations (5 and 10 mM) of Pro for 24 and 48 h contributed to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f524af2749c39ab45ef788cc9c5d92f
http://europepmc.org/articles/PMC5632346
http://europepmc.org/articles/PMC5632346
Publikováno v:
Experimental dermatology. 28(7)
The mechanism for differential effects of human immune deficiency virus protease inhibitors (HIVPIs), nelfinavir (NEL) and indinavir (IND) on collagen metabolism disturbances was studied in human skin fibroblasts. It has been considered that HIVPIs-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da130764b18c69b68668a3adf7c2f1fd
https://pubmed.ncbi.nlm.nih.gov/31077466
https://pubmed.ncbi.nlm.nih.gov/31077466
Publikováno v:
Molecular and Cellular Biochemistry
The oxythiamine (OXY) is antivitamin of thiamine. The finding that OXY increases the cytoplasmic concentration of pyruvate, known to enhance collagen biosynthesis, led us to investigate the mechanism of this antivitamin action on collagen biosynthesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b5e9f196f2c1859da17c8f26e874f2
https://doi.org/10.1007/s11010-015-2336-z
https://doi.org/10.1007/s11010-015-2336-z