Zobrazeno 1 - 10
of 306
pro vyhledávání: '"Lukasz Kurgan"'
Publikováno v:
Biomolecules, Vol 14, Iss 3, p 287 (2024)
Disordered linkers (DLs) are intrinsically disordered regions that facilitate movement between adjacent functional regions/domains, contributing to many key cellular functions. The recently completed second Critical Assessments of protein Intrinsic D
Externí odkaz:
https://doaj.org/article/e6503ee864f74734a2905b993a1c623c
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3248-3258 (2023)
We expand studies of AlphaFold2 (AF2) in the context of intrinsic disorder prediction by comparing it against a broad selection of 20 accurate, popular and recently released disorder predictors. We use 25% larger benchmark dataset with 646 proteins a
Externí odkaz:
https://doaj.org/article/bd78f0cb24f042dc8b5df45b18385d2c
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 1487-1497 (2023)
One of the key features of intrinsically disordered regions (IDRs) is their ability to interact with a broad range of partner molecules. Multiple types of interacting IDRs were identified including molecular recognition fragments (MoRFs), short linea
Externí odkaz:
https://doaj.org/article/cafd60d47b5d4d1aabb06053916e063a
Autor:
Ibrahim Yagiz Akbayrak, Sule Irem Caglayan, Lukasz Kurgan, Vladimir N. Uversky, Orkid Coskuner-Weber
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 349-355 (2022)
SARS-CoV-2 is the infectious agent responsible for the coronavirus disease since 2019, which is the viral pneumonia pandemic worldwide. The structural knowledge on SARS-CoV-2 is rather limited. These limitations are also applicable to one of the most
Externí odkaz:
https://doaj.org/article/17e46ea8b41a44c3830463414d1a8e3c
Autor:
Bi Zhao, Lukasz Kurgan
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1286-1294 (2022)
Intrinsic disorder prediction is an active area that has developed over 100 predictors. We identify and investigate a recent trend towards the development of deep neural network (DNN)-based methods. The first DNN-based method was released in 2013 and
Externí odkaz:
https://doaj.org/article/8eb34c1d0c574515b852c87ce6cb6c97
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2223-2234 (2022)
Sequence-based predictors of the residue-level protein function and structure cover a broad spectrum of characteristics including intrinsic disorder, secondary structure, solvent accessibility and binding to nucleic acids. They were catalogued and ev
Externí odkaz:
https://doaj.org/article/1f4a5fdf26984052852ae2a58c5b0ab0
Autor:
Gang Hu, Akila Katuwawala, Kui Wang, Zhonghua Wu, Sina Ghadermarzi, Jianzhao Gao, Lukasz Kurgan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
The authors present flDPnn, a computational tool for disorder and disorder function predictions from protein sequences. flDPnn was assessed with the data from the “Critical Assessment of Protein Intrinsic Disorder Prediction” experiment and on an
Externí odkaz:
https://doaj.org/article/9b467e5b636944909f7d8cf830f43acb
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 2597-2606 (2021)
A recent advance in the disorder prediction field is the development of the quality assessment (QA) scores. QA scores complement the propensities produced by the disorder predictors by identifying regions where these predictions are more likely to be
Externí odkaz:
https://doaj.org/article/794614a102f54823a23584809f906e33
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 454-462 (2019)
Molecular recognition features (MoRFs) are short protein-binding regions that undergo disorder-to-order transitions (induced folding) upon binding protein partners. These regions are abundant in nature and can be predicted from protein sequences base
Externí odkaz:
https://doaj.org/article/55b2a396fd9b491c8c7a8d4f56d9c920
Autor:
Bi Zhao, Lukasz Kurgan
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 888 (2022)
Intrinsically disordered regions (IDRs) carry out many cellular functions and vary in length and placement in protein sequences. This diversity leads to variations in the underlying compositional biases, which were demonstrated for the short vs. long
Externí odkaz:
https://doaj.org/article/ef743d194149427c985d244c40bb7fe8