Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lukasz K. Chlewicki"'
Autor:
Sarah B Dicker, Tatiyana L. Shiyanova, Patel Chetankumar Natvarlal, Stephanie Marie Truhlar, Robert J. Benschop, Stuart W. Bright, Dongmei He, Oliver Schroeder, Katie Brannon Corwin, Marikka Elia, Qing Zhang, Julian Davies, Lukasz K. Chlewicki, Angela J. Okragly
Publikováno v:
Journal of Inflammation Research
Angela J Okragly,1 Katie Brannon Corwin,2 Marikka Elia,3 Dongmei He,3 Oliver Schroeder,3 Qing Zhang,3 Tatiyana Shiyanova,2 Stuart Bright,1 Sarah B Dicker,4 Lukasz Chlewicki,4 Stephanie ME Truhlar,3 Julian Davies,3 Chetan N Patel,2 Robert J Benschop1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c7ad26d8ab3d3330a0aefbf7ef0cdf3
https://doi.org/10.2147/jir.s320287
https://doi.org/10.2147/jir.s320287
Autor:
Derrick R. Witcher, Victor J. Wroblewski, Patricia Brown-Augsburger, Jeffrey S. Boyles, Lukasz K. Chlewicki, Yi Wen, Natalia Kovalova
Publikováno v:
Biopharmaceutics & Drug Disposition. 41:111-125
The immunogenicity of biotherapeutics presents a major challenge during the clinical development of new protein drugs including monoclonal antibodies. To address this, multiple humanization and de-immunization techniques that employ in silico algorit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa96c36a17f62690ecf61881a856ee0
https://doi.org/10.1002/bdd.2222
https://doi.org/10.1002/bdd.2222
Autor:
Lukasz K. Chlewicki, Victor J Wroblewski, Patricia Brown-Augsburger, Natalia Kovalova, Michael D Knierman
Publikováno v:
Immunogenetics. 71:605-615
Immunogenicity of biomolecules is one of the largest concerns in biological therapeutic drug development. Adverse immune responses as a result of immunogenicity to biotherapeutics range from mild hypersensitivity reactions to potentially life-threate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457f68a594de16c705331d91859cc0fc
https://doi.org/10.1007/s00251-019-01136-7
https://doi.org/10.1007/s00251-019-01136-7
Autor:
Byron Burnette, Lukasz K. Chlewicki, Sogyong L. Auh, Nikolai N. Khodarev, Ralph R. Weichselbaum, Yang Xin Fu, Youjin Lee, Hua Liang
Publikováno v:
Cancer Research. 71:2488-2496
The most widely held explanation for the efficacy of local radiotherapy (RT) is based on direct cytotoxicity to cancer cells through the induction of lethal DNA damage. Recent studies have shown that local ablative radiation of established tumors can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d583ac1660396293a1e6d6d466a941a6
https://doi.org/10.1158/0008-5472.can-10-2820
https://doi.org/10.1158/0008-5472.can-10-2820
Autor:
Lukasz K. Chlewicki, Hanspeter Pircher, Maike Hofmann, Qian Wang, Roy A. Mariuzza, Leslie Teng, Yili Li
Publikováno v:
Immunity. 31(1):35-46
The cytolytic activity of natural killer (NK) cells is regulated by inhibitory receptors that detect the absence of self molecules on target cells. Structural studies of missing self recognition have focused on NK receptors that bind MHC. However, NK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c308837bbc0814f14673db213a7dc87
Autor:
Roy A. Mariuzza, Lu Deng, Marisa M. Fernández, Lukasz K. Chlewicki, C. Alejandro Velikovsky, Vinay Kumar
Publikováno v:
Immunity. 27(4):572-584
SummaryNatural killer (NK) cells eliminate virally infected and tumor cells. Among the receptors regulating NK cell function is 2B4 (CD244), a member of the signaling lymphocyte-activation molecule (SLAM) family that binds CD48. 2B4 is the only heter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cad180a25e019084d60fbd4a52ae9b
Publikováno v:
Nature Immunology. 4:55-62
T cells with high-affinity T cell receptors (TCRs) for a foreign peptide-major histocompatibility complex (pMHC) appear to be negatively selected, even though they have never seen the foreign antigen. To examine how this process operates, we used in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f455f79949dafb607badef9f95ae397
https://doi.org/10.1038/ni863
https://doi.org/10.1038/ni863
Autor:
Jieyi Wang, Haidong Tang, Lukasz K. Chlewicki, Yang Wang, Yuan Zhang, Jingya Guo, Wei Liang, Yang Xin Fu, Xiaoxiao Wang
Publikováno v:
Cancer Cell. 30:500
Immune checkpoint blockade therapies fail to induce responses in the majority of cancer patients, so how to increase the objective response rate becomes an urgent challenge. Here, we demonstrate that sufficient T cell infiltration in tumor tissues is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46ed640f18b25146638972cb7cfd7daf
https://doi.org/10.1016/j.ccell.2016.08.011
https://doi.org/10.1016/j.ccell.2016.08.011
Publikováno v:
The Journal of Immunology. 196:74.2-74.2
Recent clinical trials with checkpoint blockade antibodies have shown unprecedented durable responses in some patients with a variety of cancers. However, such therapies fail to induce responses in majority of cancer patients. How to increase the obj
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8281366dd00a8a9ea4d7d4d2edb1a03
https://doi.org/10.4049/jimmunol.196.supp.74.2
https://doi.org/10.4049/jimmunol.196.supp.74.2
Autor:
José A. Guevara-Patiño, Michael C. Jagoda, Frederick J. Kohlhapp, Andrew T. Lacek, Lukasz K. Chlewicki, Gretchen E. Lyons, Vinay Kumar, Andrew Zloza, Jeremy A. O'Sullivan, Tamson V. Moore
Publikováno v:
Autoimmunity. 44(8)
In this study, we demonstrate that engagement of two different natural killer receptors (NKRs) can lead to contrasting effects in the development of self-reactive CD8+T cells and autoimmune vitiligo. Specifically, using a mouse model, we show that CD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec9874e49328b31055a0dafa8cedaae9
https://pubmed.ncbi.nlm.nih.gov/21913803
https://pubmed.ncbi.nlm.nih.gov/21913803