Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lukasz Joachimiak"'
Autor:
Bryan Ryder, David Boyer, Elizaveta Ustyantseva, Ayde Mendoza-Oliva, Mikolaj Kuska, Pawel Wydorski, Michael Sawaya, Marc Diamond, David Eisenberg, Harm Kampinga, Lukasz Joachimiak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c58a0a018fef0e6b73335b73e8d0eeca
https://doi.org/10.2139/ssrn.4439677
https://doi.org/10.2139/ssrn.4439677
Autor:
Dailu Chen, Aleksandra Wosztyl, Vishruth Mullapudi, Sofia Bali, Jaime Vacquer-Alicea, Shamiram Melhem, Harro Seelaar, John van Swieten, Marc Diamond, Lukasz Joachimiak
Amyloid deposition of the microtubule-associated protein tau is a unifying theme in a multitude of neurodegenerative diseases. Disease-associated missense mutations in tau are associated with frontotemporal dementia (FTD) and enhance tau aggregation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c1179a05ce563319b0ed05047ae812
https://doi.org/10.21203/rs.3.rs-1950269/v1
https://doi.org/10.21203/rs.3.rs-1950269/v1
Autor:
Vishruth Mullapudi, Jaime Vacquer-Alicea, Vaibhav Bommareddy, Anthony Vega, Bryan Ryder, Charles White, Marc Diamond, Lukasz Joachimiak
Cryogenic electron microscopy has revealed unprecedented molecular insight into the conformation of β-sheet-rich protein amyloids linked to neurodegenerative diseases. It remains unknown how a protein can adopt a diversity of folds and form multiple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46806e55079fd7d202cc5d6ec3a4ac9c
https://doi.org/10.21203/rs.3.rs-1813512/v1
https://doi.org/10.21203/rs.3.rs-1813512/v1
Autor:
Lukasz Joachimiak, Zhiqiang Hou, Pawel Wydorski, Valerie Perez, Ayde Mendoza-Oliva, Bryan Ryder, Hilda Mirbaha, Omar Kashmer
Molecular chaperones, including Hsp70/Hsp40 families, play central roles in binding substrates to prevent their aggregation. How Hsp40s select different conformations of substrates remains poorly understood. Here, we report a novel interaction betwee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::308316afe87e16786d67da5a75c5249c
https://doi.org/10.21203/rs.3.rs-129204/v1
https://doi.org/10.21203/rs.3.rs-129204/v1
Autor:
Christina Oetken-Lindholm, Katarzyna M. Błażewska, Rebecca Way, Lukasz Joachimiak, Joanna Gmach, James E. Dunford, Arafath Kaja Najumudeen, Daniel Abankwa, George Breen, Fraser P. Coxon
Publikováno v:
European journal of medicinal chemistry. 84
Phosphonocarboxylate (PC) analogs of the anti-osteoporotic drugs, bisphosphonates, represent the first class of selective inhibitors of Rab geranylgeranyl transferase (RabGGTase, RGGT), an enzyme implicated in several diseases including ovarian, brea