Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Lukasz G. Migas"'
Autor:
David M. G. Anderson, Ankita Kotnala, Lukasz G. Migas, N. Heath Patterson, Léonore E. M. Tideman, Dongfeng Cao, Bibek Adhikari, Jeffrey D. Messinger, Thomas Ach, Sara Tortorella, Raf Van de Plas, Christine A. Curcio, Kevin L. Schey
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
IntroductionAge related macular degeneration (AMD) causes legal blindness worldwide, with few therapeutic targets in early disease and no treatments for 80% of cases. Extracellular deposits, including drusen and subretinal drusenoid deposits (SDD; al
Externí odkaz:
https://doaj.org/article/26cf13097cc94e109442e9a1e0f3b623
Autor:
Emilio S. Rivera, Andy Weiss, Lukasz G. Migas, Jeffrey A. Freiberg, Katerina V. Djambazova, Elizabeth K. Neumann, Raf Van de Plas, Jeffrey M. Spraggins, Eric P. Skaar, Richard M. Caprioli
Publikováno v:
Journal of Mass Spectrometry and Advances in the Clinical Lab, Vol 26, Iss , Pp 36-46 (2022)
Introduction: Although Staphylococcus aureus is the leading cause of biofilm-related infections, the lipidomic distributions within these biofilms is poorly understood. Here, lipidomic mapping of S. aureus biofilm cross-sections was performed to inve
Externí odkaz:
https://doaj.org/article/959a176e4de34ecc923569b5ab190f24
Autor:
Elizabeth K. Neumann, Nathan Heath Patterson, Jamie L. Allen, Lukasz G. Migas, Haichun Yang, Maya Brewer, David M. Anderson, Jennifer Harvey, Danielle B. Gutierrez, Raymond C. Harris, Mark P. deCaestecker, Agnes B. Fogo, Raf Van de Plas, Richard M. Caprioli, Jeffrey M. Spraggins
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100747- (2021)
Summary: Here, we describe the preservation and preparation of human kidney tissue for interrogation by histopathology, imaging mass spectrometry, and multiplexed immunofluorescence. Custom image registration and integration techniques are used to cr
Externí odkaz:
https://doaj.org/article/9ff3dda4da29436694fe0901a45d6a05
Mass spectrometry locates local and allosteric conformational changes that occur on cofactor binding
Autor:
Rebecca Beveridge, Lukasz G. Migas, Karl A. P. Payne, Nigel S. Scrutton, David Leys, Perdita E. Barran
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
The decarboxylate enzyme Fdc1 requires a prenylated flavin mononucleotide co-factor for activity. Here, the authors use a variety of mass spectrometric techniques to observe the structural changes in this protein in response to co-factor binding.
Externí odkaz:
https://doaj.org/article/82700913d4364c30a94137e5cd1da852
Autor:
Kavya Sharman, Nathan Heath Patterson, Lukasz G. Migas, Elizabeth K. Neumann, Jamie Allen, Katherine N. Gibson-Corley, Jeffrey M. Spraggins, Raf Van de Plas, Eric P. Skaar, Richard M. Caprioli
Publikováno v:
Journal of the American Society for Mass Spectrometry. 34:905-912
Autor:
Katerina V. Djambazova, Martin Dufresne, Lukasz G. Migas, Angela R. S. Kruse, Raf Van de Plas, Richard M. Caprioli, Jeffrey M. Spraggins
Publikováno v:
Analytical chemistry.
Gangliosides are acidic glycosphingolipids, containing ceramide moieties and oligosaccharide chains with one or more sialic acid residue(s) and are highly diverse isomeric structures with distinct biological roles. Matrix-assisted laser desorption/io
Autor:
Elizabeth K. Neumann, Nathan Heath Patterson, Leonoor E.M. Tideman, Lukasz G. Migas, Madeline E. Colley, Melissa A. Farrow, Jamie L. Allen, Emilio S. Rivera, Carrie E. Romer, Haichun Yang, Maya Brewer, Kavya Sharman, Raymond C. Harris, Agnes B. Fogo, Danielle B. Gutierrez, Mark P. de Caestecker, Richard M. Caprioli, Raf Van de Plas, Jeffrey M. Spraggins
SummaryThe human kidney is composed of over 26 cell types that actively coordinate with each other to form higher-order structures, such as the nephron. It is not yet understood how these structures vary throughout a single organ or amongst the same
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633e7304214faa7ad39eae8530ef1c1f
https://doi.org/10.1101/2022.04.07.487155
https://doi.org/10.1101/2022.04.07.487155
Autor:
Jeffrey M. Spraggins, Emilio S. Rivera, Katerina V. Djambazova, Elizabeth K. Neumann, Raf Van de Plas, Dustin R. Klein, Richard M. Caprioli, Lukasz G. Migas
Publikováno v:
Analytical Chemistry. 92:13290-13297
Lipids are a structurally diverse class of molecules with important biological functions including cellular signaling and energy storage. Matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) allows for direct map-ping o
Autor:
Jeffrey M. Spraggins, Richard M. Caprioli, Lukasz G. Migas, Raf Van de Plas, Jamie L. Allen, Elizabeth K. Neumann
Publikováno v:
Analytical Chemistry. 92:13084-13091
Low molecular weight metabolites are essential for defining the molecular phenotypes of cells. However, spatial metabolomics tools often lack the sensitivity, specify, and spatial resolution to provide comprehensive descriptions of these species in t
Publikováno v:
Analytical Chemistry. 92:4340-4348
Careful transfer of ions into the gas-phase permits the measurement of protein structures, with ion mobility-mass spectrometry, which provides shape and stoichiometry information. Collision cross sections (CCS) can be obtained from measurements made