Identifying multiscale translational safety biomarkers using a network-based systems approach

Autor: Giulia Callegaro, Johannes P. Schimming, Janet Piñero González, Steven J. Kunnen, Lukas Wijaya, Panuwat Trairatphisan, Linda van den Berk, Kim Beetsma, Laura I. Furlong, Jeffrey J. Sutherland, Jennifer Mollon, James L. Stevens, Bob van de Water

Publikováno v: iScience, Vol 26, Iss 3, Pp 106094- (2023)

Summary: Animal testing is the current standard for drug and chemicals safety assessment, but hazards translation to human is uncertain. Human in vitro models can address the species translation but might not replicate in vivo complexity. Herein, we

Externí odkaz: https://doaj.org/article/c1ec17ac979040d09bc96f5bae7f9e91

Inter-individual variability in activity of the major drug metabolizing enzymes in liver homogenates of 20 Individuals

Autor: Lysiane Richert, Jan N. M. Commandeur, J. Chris Vos, Shalenie P. den Braver-Sewradj, Marc van Dijk, Yongjie Zhang, Lukas Wijaya, Stefan J. Dekker, Michiel W. den Braver, Nico P. E. Vermeulen

Publikováno v: den Braver-Sewradj, S P, den Braver, M W, van Dijk, M, Zhang, Y, Dekker, S J, Wijaya, L, Vermeulen, N P E, Richert, L, Commandeur, J N M & Vos, J C 2018, ' Inter-individual variability in activity of the major drug metabolizing enzymes in liver homogenates of 20 Individuals ', Current Drug Metabolism, vol. 19, no. 4, pp. 370-381 . https://doi.org/10.2174/1389200219666180108160046
Current Drug Metabolism, 19(4), 370-381. Bentham Science Publishers B.V.

Background: Inter-individual variability in hepatic drug metabolizing enzyme (DME) activity is a major contributor to heterogeneity in drug clearance and safety. Accurate data on expression levels and activities of DMEs is an important prerequisite f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa4b0f0e4e92d26c29fcba0e5928b95
https://hdl.handle.net/1871.1/da2b916f-d52b-461a-9b0b-fd6e1d45d3e7