Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Lukas Wettstein"'
Autor:
Emanuela D’Acunto, Alessia Muzi, Silvia Marchese, Lorena Donnici, Valerio Chiarini, Federica Bucci, Emiliano Pavoni, Fabiana Fosca Ferrara, Manuela Cappelletti, Roberto Arriga, Silvia Maria Serrao, Valentina Peluzzi, Eugenia Principato, Mirco Compagnone, Eleonora Pinto, Laura Luberto, Daniela Stoppoloni, Armin Lahm, Rüdiger Groß, Alina Seidel, Lukas Wettstein, Jan Münch, Andrew Goodhead, Judicael Parisot, Raffaele De Francesco, Gennaro Ciliberto, Emanuele Marra, Luigi Aurisicchio, Giuseppe Roscilli
Publikováno v:
Antibodies, Vol 13, Iss 1, p 5 (2024)
The COVID-19 pandemic, once a global crisis, is now largely under control, a testament to the extraordinary global efforts involving vaccination and public health measures. However, the relentless evolution of SARS-CoV-2, leading to the emergence of
Externí odkaz:
https://doaj.org/article/c7871d373abc48969226325b103c6a9c
Autor:
Lukas Wettstein, Philip Maximilian Knaff, Christian Kersten, Patrick Müller, Tatjana Weil, Carina Conzelmann, Janis A Müller, Maximilian Brückner, Markus Hoffmann, Stefan Pöhlmann, Tanja Schirmeister, Katharina Landfester, Jan Münch, Volker Mailänder
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
This study describes the development and characterization of peptidomimetic inhibitors of TMPRSS2, which primes the Spike protein of SARS-CoV-2. The inhibitors are shown to prevent SARS-CoV-2 infection in cells as efficiently as camostat mesylate.
Externí odkaz:
https://doaj.org/article/1f0965b089714fc9bfce787fa886e9d3
Autor:
Caterina Prelli Bozzo, Rayhane Nchioua, Meta Volcic, Lennart Koepke, Jana Krüger, Desiree Schütz, Sandra Heller, Christina M. Stürzel, Dorota Kmiec, Carina Conzelmann, Janis Müller, Fabian Zech, Elisabeth Braun, Rüdiger Groß, Lukas Wettstein, Tatjana Weil, Johanna Weiß, Federica Diofano, Armando A. Rodríguez Alfonso, Sebastian Wiese, Daniel Sauter, Jan Münch, Christine Goffinet, Alberto Catanese, Michael Schön, Tobias M. Boeckers, Steffen Stenger, Kei Sato, Steffen Just, Alexander Kleger, Konstantin M. J. Sparrer, Frank Kirchhoff
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
IFITM proteins can inhibit several viruses, but effects on SARS-CoV-2 infection are not well understood. Here, the authors show that endogenous IFITMs support SARS-CoV-2 infection in different in vitro models by binding spike and enhancing virus entr
Externí odkaz:
https://doaj.org/article/45486c77950d4620853ea7ad4237e600
Autor:
Lukas Wettstein, Tatjana Weil, Carina Conzelmann, Janis A. Müller, Rüdiger Groß, Maximilian Hirschenberger, Alina Seidel, Susanne Klute, Fabian Zech, Caterina Prelli Bozzo, Nico Preising, Giorgio Fois, Robin Lochbaum, Philip Maximilian Knaff, Volker Mailänder, Ludger Ständker, Dietmar Rudolf Thal, Christian Schumann, Steffen Stenger, Alexander Kleger, Günter Lochnit, Benjamin Mayer, Yasser B. Ruiz-Blanco, Markus Hoffmann, Konstantin M. J. Sparrer, Stefan Pöhlmann, Elsa Sanchez-Garcia, Frank Kirchhoff, Manfred Frick, Jan Münch
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Here, via screening of a polypeptide library from bronchoalveolar lavage, the authors identify and characterize α1-antitrypsin (α1AT) as SARS-CoV-2 inhibitor and show that α1AT binds and inactivates the serine protease TMPRSS2, which enzymatically
Externí odkaz:
https://doaj.org/article/056726122e3545e6b5177624a1dc537a
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1351 (2022)
TMPRSS2 is a type II transmembrane protease with broad expression in epithelial cells of the respiratory and gastrointestinal tract, the prostate, and other organs. Although the physiological role of TMPRSS2 remains largely elusive, several endogenou
Externí odkaz:
https://doaj.org/article/e9ed1f9e875f4d2e8e360b3ef0634e21
Autor:
Lukas Wettstein, Patrick Immenschuh, Tatjana Weil, Carina Conzelmann, Yasser Almeida‐Hernández, Markus Hoffmann, Amy Kempf, Inga Nehlmeier, Rishikesh Lotke, Moritz Petersen, Steffen Stenger, Frank Kirchhoff, Daniel Sauter, Stefan Pöhlmann, Elsa Sanchez‐Garcia, Jan Münch
Publikováno v:
J Med Virol
Host cell proteases such as TMPRSS2 are critical determinants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tropism and pathogenesis. Here, we show that antithrombin (AT), an endogenous serine protease inhibitor regulating coagulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bd5810a6eea5f46644b56cf5875acbb
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85138178393
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85138178393
Autor:
Lukas Wettstein, Patrick Immenschuh, Tatjana Weil, Carina Conzelmann, Yasser Almeida‐Hernández, Markus Hoffmann, Amy Kempf, Inga Nehlmeier, Rishikesh Lotke, Moritz Petersen, Steffen Stenger, Frank Kirchhoff, Daniel Sauter, Stefan Pöhlmann, Elsa Sanchez‐Garcia, Jan Münch
Publikováno v:
Journal of Medical Virology. 95
Autor:
Philip Maximilian Knaff, Patrick Müller, Christian Kersten, Lukas Wettstein, Jan Münch, Katharina Landfester, Volker Mailänder
Publikováno v:
Biomacromolecules. 23(6)
In many solid tumors, increased upregulation of transmembrane serine proteases (TTSPs) leads to an overactivation of growth factors, which promotes tumor progression. Here, we have used a combinatorial methodology to develop high-affinity tetrapeptid
Autor:
Tatjana Weil, Abbna Kirupakaran, My-Hue Le, Philipp Rebmann, Joel Mieres-Perez, Leila Issmail, Carina Conzelmann, Janis A. Müller, Lena Rauch, Andrea Gilg, Lukas Wettstein, Rüdiger Groß, Clarissa Read, Tim Bergner, Sandra Axberg Pålsson, Nadja Uhlig, Valentina Eberlein, Heike Wöll, Frank-Gerrit Klärner, Steffen Stenger, Beate M. Kümmerer, Hendrik Streeck, Giorgio Fois, Manfred Frick, Peter Braubach, Anna-Lena Spetz, Thomas Grunwald, James Shorter, Elsa Sanchez-Garcia, Thomas Schrader, Jan Münch
Publikováno v:
JACS Au
The COVID-19 pandemic caused by SARS-CoV-2 presents a global health emergency. Therapeutic options against SARS-CoV-2 are still very limited but urgently required. Molecular tweezers are supramolecular agents that destabilize the envelope of viruses
Autor:
Matteo Iannacone, Abraham Nyska, Chiara Perucchini, Grazia Vitagliano, Davide Marotta, Rüdiger Groß, Fabio Palombo, Emanuela D’Acunto, Roberto Arriga, Valeria Fumagalli, Elena Criscuolo, Nicasio Mancini, Fabiana Fosca Ferrara, Leonardo Giustini, Elisa Bono, Erika Salvatori, Eleonora Sala, Emiliano Pavoni, Daniela Stoppoloni, Matteo Conti, Jemma Paterson, Antonella Conforti, Federica Bucci, Giuseppe Roscilli, Lukas Wettstein, Manuela Cappelletti, Luigi Aurisicchio, Lucia Lione, Jan Münch, Mirco Compagnone, Nicola Clementi, Giuseppe Ippolito, Alessia Muzi, Raffaele De Francesco, Valerio Chiarini, Maria Rosaria Capobianchi, Emanuele Marra, Alina Seidel, Amy-Rose Challis, Gianfranco Caselli, Mirela Kuka, Eleonora Pinto, Lucio C. Rovati, Luca G. Guidotti, Concetta Castilletti, Micol Ravà, Pietro Di Lucia, Mariano Maffei, Gennaro Ciliberto, Francesca Colavita, Giulia Matusali, Maria Lucrezia Pacello, Laura Luberto, Lorena Donnici, Kathryn A. Ryan
The COVID-19 pandemic caused by the β-coronavirus SARS-CoV-2 has made the development of safe and effective vaccines a critical global priority. To date, four vaccines have already been approved by European and American authorities for preventing CO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4fe8e21cb40b0fe1a1b109d257163ca
https://doi.org/10.1101/2021.06.14.448343
https://doi.org/10.1101/2021.06.14.448343