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Lipophilic Oligopeptides for Chemo- and Enantioselective Acyl Transfer Reactions onto Alcohols

Autor: Peter R. Schreiner, Raffael C. Wende, Daniela Zell, Radim Hrdina, Christian E. Müller, Lukas Wanka, Sören M. M. Schuler

Publikováno v: The Journal of Organic Chemistry. 78:8465-8484

Inspired by the extraordinary selectivities of acylases, we envisioned the use of lipophilic oligopeptidic organocatalysts for the acylative kinetic resolution/desymmetrization of rac- and meso-cycloalkane-1,2-diols. Here we describe in a full accoun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff6ca3edb94247c1d3f7604189f5def2
https://doi.org/10.1021/jo401195c

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Pharmacologic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Aβ and tau pathologies in 3xTg-AD mice

Autor: Yunn-Chyn Tung, Inge Grundke-Iqbal, Maria del Carmen Cardenas-Aguayo, Frank M. LaFerla, Khalid Iqbal, Lukas Wanka, Julie Blanchard

Publikováno v: Acta Neuropathologica. 120:605-621

In addition to the occurrence of numerous neurofibrillary tangles and Aβ plaques, neurogenesis and neuronal plasticity are markedly altered in Alzheimer disease (AD). Although the most popular therapeutic approach has been to inhibit neurodegenerati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3830adf0c4b2947543daab220c65d4c9
https://doi.org/10.1007/s00401-010-0734-6

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Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice

Autor: Fei Liu, Lukas Wanka, Inge Grundke-Iqbal, Muhammad Omar Chohan, Julie Blanchard, Khalid Iqbal, Bin Li

Publikováno v: FEBS Letters. 584:3359-3365

Development of neurotrophic peptidergic drugs that can mimic neurotrophins and promote neurogenesis and maturation of newborn cells into mature functional neurons represents an exciting therapeutic opportunity for treatment of Alzheimer disease and o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d54792545851e6fd10cbb17e59f740e
https://doi.org/10.1016/j.febslet.2010.06.025

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ChemInform Abstract: Enantiomerically Enriched trans-Diols from Alkenes in One Pot: A Multicatalyst Approach

Autor: Lukas Wanka, Christian E. Mueller, Raffael C. Wende, Radim Hrdina, Peter R. Schreiner

Publikováno v: ChemInform. 43

A non-natural oligopeptide with distinctly different catalytic moieties catalyzes a multistep one-pot sequence starting from simple alkenes (I) yielding highly enantiomerically enriched trans-diols (III).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::af1bd46d8eba9c1dade591115cf90c79
https://doi.org/10.1002/chin.201227023

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Enantiomerically enriched trans-diols from alkenes in one pot: a multicatalyst approach

Autor: Peter R. Schreiner, Radim Hrdina, Christian E. Müller, Raffael C. Wende, Lukas Wanka

Publikováno v: Chemical communications (Cambridge, England). 48(19)

Multicatalysts consisting of non-natural oligopeptides with distinctly different catalytic moieties create molecular complexity in a multistep one-pot sequence starting from simple alkenes yielding highly enantiomerically enriched trans-diols.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1581aae860bb96d8a05b1be7aebd0a96
https://pubmed.ncbi.nlm.nih.gov/22286064

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